EGZERSİZİN LEPTİN DÜZEYLERİ ÜZERİNE ETKİSİ, LEPTİNİN SOLUNUM VE KARDİYOVASKÜLER PARAMETRELER İLE İLİŞKİSİ

Abstract

Obezite ve obezite ilişkili hastalıklar ile leptin hormonu arasında önemli bir ilişkinin olduğu yapılan araştırmalar ile belirlenmiştir. Obeziteyi düzeltici faktörlerden birisi düzenli yapılan egzersizlerdir. Egzersiz, leptin hormonu yapımını ve salgılanmasını etkileyerek obezite yada obezite ilişkili hastalıklardaki iyileştirici etkisini oluşturabilir. Sunulan bu çalışma düzenli spor yapmanın yada kısa süreli egzersizin, serum leptin düzeylerine etkisi, serum leptin düzeyleri ile arteryal kan basıncı (sistolik, diyastolik basınç), nabız, plazma nitrik oksit düzeyleri ve solunum parametreleri arasındaki ilişkinin araştırılmasını amaçlamıştır. Araştırmada dört grup çalışılmıştır. Grupları sırası ile 1. düzenli spor yapan 15 kız, 2. düzenli spor yapan 15 erkek, 3. spor yapmayan 15 kız, 4. spor yapmayan 15 erkek şeklinde oluşmaktadır. Serum leptin düzeyleri, kan basınçları ve plazma nitrik oksit konsantrasyonları dört grupta da egzersiz öncesi, sonrası ve egzersizden yarım saat sonrası belirlenmiştir. Solunum parametreleri, gönüllü öğrenciler egzersiz yaparlarken belirlenmiştir. Kız ve erkek öğrencilerin serum leptin düzeyleri düzenli spor yapıp- yapmamayla ilişkili olarak istatistiksel açıdan anlamlı farklılık göstermiştir. Serum leptin düzeyleri/vücut kitle indeksi oranları için düzenli spor yapan ve hiç spor yapmayan kızlar arasında istatiksel olarak anlamlı fark bulunmuştur. Egzersiz öncesi dört grubun toplamında serum leptin düzeyi- boy (r=0.259, p<0.001), serum leptin düzeyi-nabız (r=0.006, p<0.05) parametreleri arasında ilişki bulunmuştur. Egzersizden hemen sonra dört grubun toplamında serum leptin düzeyi – maksimum oksijen tüketimi (r=0.059, p<0.04) serum leptin düzeyi-oksijen tüketimi (r=0.058, p<0.04), serum leptin düzeyi-DB (r=0.075, p<0.02) parametreleri arasında ilişki bulunmuştur. Spor yapma serum leptin düzeylerini azaltmaktadır. Sonuç olarak leptin hormonunun, vücut sistemlerinin egzersize uyumunu sağlamada aracı bir göreve sahip olabileceği düşünülmüştür

Keywords

• Leptin, egzersiz, solunum sistemi, kardiyovasküler sistem

Effects of Exercise on Plasma Leptin Concentrations and Relation of Leptin to Respiratory,Cardiovascular Parameters

Abstract

Previous research indicate that serum leptin levels are highly correlated to obesity and obesityinduced disorders. Regular exercise has a reductive effect on obesity. Exercise affect the production and secretion of leptin. This positively contribesting to obesity and obesity-related diseases. We aimed to research the effect of regular physical activity and strenuous short-time exercise on serum leptin levels and the relationships between leptin and arterial pressure, nitric oxide (NO) and ventilation. The study consisted of four groups. 1. The two groups consisted of 15 female (grup 1) and 15 male (grup 2) who are regular exercise students. Other two groups were 15 female (grup 3) and 15 male (grup 4) students who lived sedentarily. Serum leptin levels, blood pressures and plasma nitric oxide levels were determined in four groups before and immediately after cessation of exercise and 30 minutes after the end of the exercise period. Respiratory parameters were determined in four groups during exercise period. The leptin levels were significantly different among the groups. Serum leptin levels and serum leptin levels/ body mass index rations were significantly different between female students who did regular exercise and those who did not. There were significant positive correlations in all students between serum leptin levels and height (r=0.259, p<0.001), heart rate (r=0.006, p<0.05) before exercise. There were significant positive correlation in all students between serum leptin levels and diastolic pressure (r=0.075, p<0.02), significant negative correlations between serum leptin levels and VO2(r=0.058, p<0.04), VO2 max (r=0.059, p<0.04). Physical activity has decreased serum leptin levels. In conclusion, serum leptin hormone may play an intermediary role in adapting the body systems to compliance with exercise

Keywords

• Leptin, exercise, respiratory system, cardiovascular system

References

1. Zhang W, Telemague-Potts S, Andersan PR, et al. Adenoviral leptin as gene therapy for obesity related hypertension. Am J Hypertens 2002, 15: 1A (Özet)
2. Friedmen JM. The function of leptin in nutrition, weight and physiology, Nutr Rev 2002, 60: 51-514
3. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor OB-R. Cell 1995, 83(7): 1263-71
4. Ahima RS, Osei SY. Leptin signaling. Phys Behav 2004, 81: 223-241
5. Tartaglia LA. The leptin receptor. J Biol Chem 1997, 272: 6093-6096
6. Muraoka O, Xu B, Tsurumaki T, et al. Leptin- induced transactivation of NPY gene promoter mediated by JAK 1, JAK2 and STAT 3 in the neural cell lines. Neurochem Int 2003, 42: 591-601
7. Peelman F, Waelput W, Iserentat H, et al. Leptin: linking adipocite metabolism with cardiovascular and autoimmune disease . Prog Lipid Res 2003, 43: 283-301
8. Chua SC, Chung WK, Wu-Peng Xs, et al. Phetypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996, 271: 1994-1996

9. Clement K, Vaisse C, Nahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998, 392: 398-401
10. Wu-Peng XS, Chua SC, Okada N, et al. Phenotype of the obes Koletsky(f) rat due to Tyr763Stop mutation in the extracellular do- main of the leptin receptor( Lepr): evidence for deficient plasma-to-CSI transport of leptin in both the Zucker and Koletsky obese rat. Diabetes 1997, 46: 513-518
11. Correia MLG and Haynes WG. Obesity- related hypertension: Is there a role for selective leptin resistance? Curr Hypertens Reports 2004, 6: 230-235
12. Toth MJ, Goran MI, Ades PA, et al. Examination of data normalization procedures for expressing peak VO2 data. J Appl Physiol 1993, 75: 2288
13. Harmelen VV, Reynisdottir S, Ericson P, et al. Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998, 47: 913
14. O’Donnell CP, Scahaub CD, Haines AS et al. Leptin prevents respiratory depression in obesity. Am J Rest Crit Care Med 2000, 159: 1477-1484
15. O’Donnell CP,Tankersley CG, Polotsky VP et al. Leptin, obesity, and respiratory function. Respir Physiol 2000,:119, 163-170.
16. Nagy T, Bower G, Trowbridge C, et al. Effects of gender, ethnicity, body composition and fat distribution on serum leptin levels in children. J Clin Endocrinol Metab 1997, 82: 2148
17. Arto K, Sandra T. The calcium dependent nitric oxide production of human vascular endothelial cell in preeclamsia. Am J Obstet. Gynecol 1996, 174: 1056-1060
18. Miller GD, PhD, Frost R, et al. Relation of plasma leptin concentrations to sex body fat, dietary ıntake, and peak oxygen uptake in young adult women and men. Nutrition 2001, 17: 105-111
19. Clayton P, Gill M, Hall C, et al. Serum leptin through childhood and adolescence. Clin Endocrinol 1997, 46: 737
20. Dirlewanger M, Di Vetta V, et al. Effect of moderate physical activity on plasma leptin concentrations in humans. Eur J Appl Physiol 1999, 79: 331-335
21. Kraemer RR, Kraemer GR, Acevedo EO, et al. Effects of aerobic exercise on serum leptin levels in obese females. Eur J Appl Physiol 1999, 80:154-158
22. Shek EW, Brands MW and Hall JE. Chronic leptin infusion increased arterial pressure. Hypertension. 1998, 31: 409-414