CURRENT TREATMENT APPROACHES WITH SOMATOSTATIN

Abstract

Somatostatin is a neuropeptide that is secreted from the hypothalamus and inhibits the release of growth hormone from the pituitary. Because of the short half-life of somatostatin, various somatostatin analogues have been developed. Octreotide, Vapreotide, Lanreotide and Pasireotide, which are somatostatin analogues, are selective active ingredients that bind to somatostatin receptors with high affinity. While these analogues have been routinely used in the treatment of pancreatitis, acromegaly, esophageal variceal bleeding, there are some researches on these analogues that may also be useful in some types of cancer and neurodegenerative diseases.

This review provides a pharmacologically current view of the biological functions, receptors, analogues and potential therapeutic uses of somatostatin.

Keywords

• Vapreotide,Octreotide,neurodegeneration,anticancer

SOMATOSTATİN ANALOGLARI İLE GÜNCEL TEDAVİ YAKLAŞIMLARI

Abstract

Somatostatin, hipotalamustan salgılanan ve hipofizden büyüme hormonu salımını inhibe eden bir nöropeptiddir. Somatostatinin yarılanma ömrünün kısa olmasından dolayı çeşitli somatostatin analogları geliştirilmiştir. Somatostatin analogları olan Oktreotid, Vapreotid, Lanreotid ve Pasireotid somatostatin reseptörlerine yüksek afinite ile bağlanan selektif etken maddelerdir. Bu analoglar, pankreatit, akromegali, özofagus varis kanamasının tedavisinde rutin olarak kullanılırken bazı kanser türlerinde ve nörodejeneratif hastalıklarda da faydalı olabileceklerine dair araştırmalar mevcuttur.

Bu derleme, somatostatinin biyolojik fonksiyonlarına, reseptörlerine, analoglarına ve potansiyel terapötik kullanımlarına farmakolojik olarak güncel bir görüş sunmaktadır.

Keywords

• Vapreotid,Oktreotid,nörodejenerasyon,antikanser

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