CURRENT TREATMENT APPROACHES WITH SOMATOSTATIN

Yıl 2020, , 133 - 137, 25.09.2020

Ebru Uzunhisarcıklı , Mükerrem Betül Yerer

https://doi.org/10.34108/eujhs.643600

Öz

Somatostatin
is a neuropeptide that is secreted from the hypothalamus and inhibits the
release of growth hormone from the pituitary. Because
of the short half-life of somatostatin, various somatostatin analogues have
been developed. Octreotide, Vapreotide, Lanreotide and Pasireotide,
which are somatostatin analogues, are selective active ingredients that bind to
somatostatin receptors with high affinity. While these analogues have been
routinely used in the treatment of pancreatitis, acromegaly, esophageal
variceal bleeding, there are some researches on these analogues that may also
be useful in some types of cancer and neurodegenerative diseases.

This review
provides a pharmacologically current view of the biological functions,
receptors, analogues and potential therapeutic uses of somatostatin.

Anahtar Kelimeler

Vapreotide, Octreotide, neurodegeneration, anticancer

SOMATOSTATİN ANALOGLARI İLE GÜNCEL TEDAVİ YAKLAŞIMLARI

Öz

Somatostatin, hipotalamustan salgılanan ve
hipofizden büyüme hormonu salımını inhibe eden bir nöropeptiddir.
Somatostatinin yarılanma ömrünün kısa olmasından dolayı çeşitli somatostatin
analogları geliştirilmiştir. Somatostatin analogları olan
Oktreotid, Vapreotid, Lanreotid ve Pasireotid somatostatin reseptörlerine
yüksek afinite ile bağlanan selektif etken maddelerdir. Bu analoglar,
pankreatit, akromegali, özofagus varis kanamasının tedavisinde rutin olarak
kullanılırken bazı kanser türlerinde ve nörodejeneratif hastalıklarda da
faydalı olabileceklerine dair araştırmalar mevcuttur.

Bu derleme, somatostatinin biyolojik
fonksiyonlarına, reseptörlerine, analoglarına ve potansiyel terapötik
kullanımlarına farmakolojik olarak güncel bir görüş sunmaktadır.

Anahtar Kelimeler

Vapreotid, Oktreotid, nörodejenerasyon, antikanser

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