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İç Anadolu'da enfeksiyöz bronşit virüsü aşılamasının etkinliği

Year 2020, Volume: 31 Issue: 2, 147 - 153, 31.12.2020
https://doi.org/10.35864/evmd.796390

Abstract

Özet: Enfeksiyöz bronşit virüsü (IBV) kümes hayvanlarında solunum sistemini etkileyen, akut ve hızla yayılan, yumurta verim ve kalitesini etkileyerek ekonomik kayıplara neden olan bir virüstür. Dünya çapında bir dağılımı ve % 100'e ulaşabilen yüksek morbidite oranı vardır. Araştırmamızda İç Anadolu Bölgesi’ndeki 11 yumurtacı kümesten alınan, 599 adet kan örneği incelenmiştir. IBV ile aşılanan kümeslerden toplanan 599 adet kan serum örneğinde, bir kümeste, düşük titre (842) ve yüksek CV (% 84) saptanmıştır. Tüm sonuçlar değerlendirildiğin de iki kümeste ise antikor titresi 2318 ve 1283 elde edilirken, %CV değerleri sırasıyla 93 ve 90 bulunmuştur. Diğer 8 kümesten elde edilen antikor titrelerinin 1 ile 18903, % CV değerlerinin ise 0 ile 63 arasında değiştiği bulunmuştur. Sonuç olarak araştırmamıza dahil olan kümeslerden elde edilen antikor titreleri ve % CV değerlerine bakıldığında; yüksek antikor titreleri-yüksek %CV değerleri veya düşük antikor titreleri-yüksek %CV değerleri, halen ülkemizde aşılama ile ilgili sorunların varlığını göstermektedir. Bu durum kümeslerde arzulanan homojen antikor titrelerine ulaşılmaması nedeniyle, kanatlı sürülerini enfeksiyon riskiyle karşı karşıya getirebileceği kanaatindeyiz.

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References

  • Kaynaklar Ahmed Z, Naeem K, Hameed A. (2007). Detection and seroprevalence of infectious bronchitis virus strains in commercial poultry in Pakistan. Poult Sci. 86, 1329– 1335.
  • Awad F, Chhabra R, Baylis M, Ganapathy K. (2014). An overview of infectious bronchitis virus in chickens. Worlds Poult Sci J 70, 375.
  • Ballal A, Karrar AE, ElHussein AM. (2005). Serosurvillance study on avian infectious bronsitis virus in Sudan. J Anim and Vet Advances. 4(11), 908-909.
  • Bande F, Arshad SS, Bejo MH, Moeini H, Omar AR. (2015). Progress and challenges toward the development of vaccines against avian infectious bronchitis. J Immunol Res. Article ID 424860, 12 pages.
  • Bhuiyan ZA, Giasuddin MD, Uddin Z, Khan M. (2018). Seroprevalence of infectious bronchitis virus in different types of chicken in Bangladesh. Asian J Med Biol Res. 4 (1), 132-136.
  • Bijlenga G, Cook JKA, Gelb J, De Wit JJ. (2004). Development and use of the H strain of avian infectious bronchitis virus from the Netherlands as a vaccine: A review. Avian Pathol, 33, 550–557.
  • Boltz DA, Nakai M, and Bahra JM. (2004). Avian infectious bronchitis virus: A possible cause of reduced fertility in the rooster. Avian Dis. 48, 909-915.
  • Boroomand Z, Razeghian I, Asasi K, Mohammadi A, & Noohadani AH. (2011). Isolation and identification of a new isolate of avian infectious bronchitis virüs IRFIBV32 and a study of its pathogenicity. Online J of Vet Res.15, 366-80.
  • Bourogâa H, Miled K, Larbi I, Nsiri J, Gribaa L, Behi I, Benrhouma W, Allegui F, Sassi H, Ghram A. (2009). Avian infectious bronchitis disease in Tunisia:seroprevalence, pathogenicity and compatibility studies ofvaccine-field isolates. Arch Inst Pasteur Tunis. 86, 75–83.
  • Bourogâa H, Larbi I, Miled K, Hellal YK, Hassen J, Behi I, Nsiri J, Ghram A. (2014). Evaluation of protection conferred by a vaccination program based on the H120 and CR88 commercial vaccines against a field variant of avian infectious bronchitis virüs. J Appl Poult Res. 23, 156–164.
  • Bronzoni RV, Fatima M, Montassier S, Pereira GT, Gama NM, Sakai V, Montassier HJ. (2005). Detection of infectious bronchitis virus and specific anti- viral antibodies using a Concanavalin A-Sandwich-ELISA. Viral Immunol.18, 569–578.
  • Cardoso WM, Aguiar JLC, Romao JM. (2005). Effect of Associated Vaccines on the Interference between Newcastle Disease Virus and Infectious Bronchitis Virus in Broilers. Brazilian J of Poultry Science. 3, 181–184.
  • Cardoso WM, Gomes LP, Romão JM, Salles RPR, Teixeira RSC, Sobral MHNR, Câmara SR, Oliveira WF. (2006). Antibodies specific to infectious bronchitis in broilers in Ceará state. Brazil Arq Bras Med Vet Zootec. 58(3), 327-332.
  • Cardoso WM, Gomes LP, Romão JM, Salles RPR, Teixeira RSC, Sobral MHNR, Câmara SR, Oliveira WF. (2006). Antibodies specific to infectious bronchitis in broilers in Ceará state, Brazil Arq. Bras Med Vet Zootec. 58(3), 327-332.
  • Cavanagh D, Davis PJ, Pappin DJ, Binns MM, Boursnell ME, Brown TD. (1986): Coronavirus IBV: partial amino terminal sequencing of spike polypeptide S2 identifies the sequence Arg-Arg-Phe-Arg-Arg at the cleavage site of the spike precursor propolypeptide of IBV strains Beaudette and M41. Virus Res. 4,133–143.
  • Cavanagh D, Davis PJ, Cook J. (1992): Infectious bronchitis virus: evidence for recombination within the Massachusetts serotype. Avian Pathol. 21, 401–408.
  • Cavanagh D. (1997). Nidovirales: A new order comprising Coronoviridae and Arteriviridae. Arch Virol. 142, 629–633.
  • Cavanagh D. & Naqi SA. (1997). Infectious bronchitis. In B.W. Calnek, H.J. Barnes, C.W. Beard, W.M. Reid & H.W. Yoder Jr. (Eds.), Diseases of Poultry 10th edn p. Ames, IA: Iowa State University Press. P. 511–526.
  • Cavanagh D. (2003). Severe acute respirarory syndrome vaccine development: experience of vaccination against avian infectious bronchitis coronovirus. Avian Pathol. 32(6), 567-582.
  • Cook JK, Davison TF, Huggins MB, McLaughlan P. (1991). Effect of in ovo bursectomy on the course of an infectious bronchitis virus infection in line C White Leghorn chickens. Arch Virol. 118, 225–34. Cook JK, Orbell SJ, Woods MA, Huggins MB. (1999). Breadth of protection of the respiratory tract provided by different live-attenuated infectious bronchitis vaccines against challenge with infectious bronchitis viruses of heterologous serotypes. Avian Pathol. 28(5), 477–85.
  • Cook JKA, Huggins MB, Orbell SJ, Mawditt K, Cavanagh D. (2001). Infectious bronchitis virus vaccine interferes with the replication of avian pneumovirus vaccine in domestic fowl. Avian Pathol. 30, 233-242.
  • Cook J. (2002). Coronaviridae. In: Jordan, F; Pattison, M; Alexander, D and Faragher, T (Eds.), Poultry diseases. (5th. Edn.), London,W. B. Saunders Co. P. 298-306.
  • Cook JKA. (2008). Coronaviridae. In: Pattison M, Bradbury A, editors. Poultry diseases. 6th ed. Amsterdam: Saunders Elsevier. p. 340-349.
  • Cook JKA, Jackwood M, Jones RC. (2012). The long view: 40 years of infectious bronchitis research. Avian Pathol. 41, 239–50.
  • de Herdt P, Ducatelle AR, Uyttebroek AE. (2001). Infectious bronchitis serology in broilers and broiler breeders: correlations between antibody titers and performance in vaccinated flocks. Avian Dis. 45, 612-619.
  • de Wit JJ, Cook JKA,Van Der Heijden HMJF. (2011). Infectious bronchitis virus variants: a review of the history, current situation and control measures. Avian Pathol. 40, 223–235.
  • Esendal MÖ. (2002). Enfeksiyöz Bronsitis, Kanatlı Hayvan Hastalıkları. Editörler: İzgür.M., Akan.M., Medisan Yayınları.50. Ankara, s: 155-162.
  • Gelb JJ, Nix WA, Gellman SD. (1998). Infectious bronchitis virus antibodies in tears and their relationship to immunity. Avian Dis. 42, 364–74.
  • Gelb JJr, Campion L, Ladman B. (2004). Interferência na replicação entre os vírus dabronquite infecciosa e da doença de Newcastle. In: Anais vol.1 da Conferência Apinco de Ciência e Tecnologias Avícolas. São Paulo-Brasil. p., 63-70.
  • Hamadan AM, Ghalyanchilangeroudia A, Hashemzadehb M, Hosseinic H, Karimid V, Yahyaraeyata R, Najafia H. (2017). Genotyping of Avian infectious bronchitis viruses in Iran (2015–2017) reveals domination of IS-1494 like virus. Virus Res. 240, 101-106.
  • Ignjatovic J Galli L. (1994). The S1 glycoprotein but not the N or M proteins of avian infectious bronchitis virus induces protection in vaccinated chickens. Archives of Virol. 138, 117–134.
  • Ignjatovic J & Sapats S. (2000). Avian infectious bronchitis virus. Révue Scientifique et Technique (Office Internationaldes Epizooties). 19, 493–508.
  • Jackwood MW, Hilt DA, Brown TP. (2003). Attenuation, safety, and efficacy of an infectious bronchitis virus GA98 serotype vaccine. Avian Dis. 47(3), 627–32.
  • Jackwood MW. (2010). Control of Arkansas infectious bronchitis virus by vaccination. Avian Insight. 3, 1–4.
  • Jia W, Karaka K, Parrish CR. (1995). A novel variant of avian infectious bronchitis virus resulting from recombination among three different strains. Arch Virol. 140, 259-271.
  • Kahya S, Çöven F, Temelli S, Eyigör A, Çarlı KT. (2013). Presence of IS/1494/06 genotype-related infectious bronchitis virus in breeder and broiler flocks in Turkey. Ankara Üniv Vet Fak Derg. 60,27-31.
  • Karimi V, Ghalyanchilangeroudi A, Hashemzadeh M, Rahimi F, Petroudi MTZ, Farahani RKH, Maghsoudloo H, Abdollahi H, (2018). Efficacy of H120 and Ma5 avian infectious bronchitis vaccines in early challenge against QX strain. Virus Dis. 29(1),123–126.
  • Lee CW, Jackwood MW. (2000): Evidence of genetic diversity generated by recombination among avian coronovirus IBV. Arch Virol. 145, 2135–2148.
  • Marcin S, Bartlomiej T, Daria D, Tomasz S, Andrzej K. (2017). Immunological aspects of the efficiency of protectotype vaccination strategy against chicken infectious bronchitis. BMC Veterinary Res. 13, 44.
  • Matthijs MGR, Van Eck JHH, Landman WJM, Stegeman JA. (2003). Ability of Massachusetts-type infectious bronchitis virus to increase colibacillosis susceptibility in commercial broilers: A comparison between vaccine and virulent field virus. Avian Pathol.32, 473–481.
  • McKinley ET, Hilt DA, Jackwood MW. (2008). Avian coronavirus infectious bronchitis attenuated live vaccines undergo selection of subpopulations and mutations following vaccination. Vaccine. 26, 1274– 1284.
  • OIE. Manual of standards for diagnostic tests and vaccines. Office International des Epizooties, World Organisation for Animal Health, Paris. 2000. www.oie.int Erişim Ağustos 2020)
  • Okino CH, Alessi AC, Montassier MDFS, Rosa AJDM, Wang X, Montassier HJ. (2013). Humoral and cell-mediated immune responses to different doses of attenuated vaccine against avian infectious bronchitis virus. Viral Immunol. 26(4),259–67 .
  • Okino CH, dos Santos IL, Fernando FS, Alessi AC, Wang X, Montassier HJ. (2014). Inflammatory and cell-mediated immune responses in the respiratory tract of chickens to infection with avian infectious bronchitis virus. Viral Immunol. 27, 383–9.
  • Otsuki K, Huggins MB, Cook JKA. (1990). Comparison of the susceptibility to avian infectious bronchitis virus infection of two inbred lines of white leghorn chickens. Avian Pathol. 19, 467–475.
  • Roussan DA, Totanji WS, Khawaldeh GY. (2008). Molecular subtype of infectious bronchitis virus in broiler flocks in Jordan. Poult Sci. 87, 661–664.
  • Shapouri S, Mayahi MR, Asasi MK, Charkhkar S. (2004). A survey of the prevalence of infectious bronchitis virus type 4.91 in Iran. Acta Vet Hungarica. 52, 163–166.
  • van Ginkel FW, van Santen VL, Gulley SL, Toro H. (2008). Infectious bronchitis virus in the chicken Harderian gland and lacrimal fluid: Viral load, infectivity, immune cell responses, and effects of viral immunodeficiency. Avian Dis. 52, 608–17

The efficacy of infectious bronchitis virus vaccination in Central Anatolia

Year 2020, Volume: 31 Issue: 2, 147 - 153, 31.12.2020
https://doi.org/10.35864/evmd.796390

Abstract

Infectious bronchitis virus (IBV) is an acute and rapidly spreading virus that affects the respiratory system in poultry, causing economic losses by affecting egg yield and quality. It has a worldwide distribution and a high morbidity rate reaching 100%. In our research, 599 blood samples collected from 11 laying flocks in Central Anatolian region were examined. In 599 blood serum samples collected from IBV vaccinated flocks, low titer (842) and high CV (84%) were detected in one of the flocks. When all results were evaluated, antibody titres of 2318 and 1283 were obtained in two flocks, while CV% values were found to be 93 and 90, respectively. It was found that antibody titers from the other 8 poultry houses ranged from 1 to 18903, and CV% values ranged from 0 to 63. As a result, when we look at the antibody titers and CV% values obtained from the poultry houses included in our study; high antibody titers-high CV% values or low antibody titers- high CV% values, indicated the existence of vaccination-related problems in our country. We believe that this may confronted poultry flocks at risk of infection due to the desired homogeneous antibody titres are not achieved in the poultry houses.

References

  • Kaynaklar Ahmed Z, Naeem K, Hameed A. (2007). Detection and seroprevalence of infectious bronchitis virus strains in commercial poultry in Pakistan. Poult Sci. 86, 1329– 1335.
  • Awad F, Chhabra R, Baylis M, Ganapathy K. (2014). An overview of infectious bronchitis virus in chickens. Worlds Poult Sci J 70, 375.
  • Ballal A, Karrar AE, ElHussein AM. (2005). Serosurvillance study on avian infectious bronsitis virus in Sudan. J Anim and Vet Advances. 4(11), 908-909.
  • Bande F, Arshad SS, Bejo MH, Moeini H, Omar AR. (2015). Progress and challenges toward the development of vaccines against avian infectious bronchitis. J Immunol Res. Article ID 424860, 12 pages.
  • Bhuiyan ZA, Giasuddin MD, Uddin Z, Khan M. (2018). Seroprevalence of infectious bronchitis virus in different types of chicken in Bangladesh. Asian J Med Biol Res. 4 (1), 132-136.
  • Bijlenga G, Cook JKA, Gelb J, De Wit JJ. (2004). Development and use of the H strain of avian infectious bronchitis virus from the Netherlands as a vaccine: A review. Avian Pathol, 33, 550–557.
  • Boltz DA, Nakai M, and Bahra JM. (2004). Avian infectious bronchitis virus: A possible cause of reduced fertility in the rooster. Avian Dis. 48, 909-915.
  • Boroomand Z, Razeghian I, Asasi K, Mohammadi A, & Noohadani AH. (2011). Isolation and identification of a new isolate of avian infectious bronchitis virüs IRFIBV32 and a study of its pathogenicity. Online J of Vet Res.15, 366-80.
  • Bourogâa H, Miled K, Larbi I, Nsiri J, Gribaa L, Behi I, Benrhouma W, Allegui F, Sassi H, Ghram A. (2009). Avian infectious bronchitis disease in Tunisia:seroprevalence, pathogenicity and compatibility studies ofvaccine-field isolates. Arch Inst Pasteur Tunis. 86, 75–83.
  • Bourogâa H, Larbi I, Miled K, Hellal YK, Hassen J, Behi I, Nsiri J, Ghram A. (2014). Evaluation of protection conferred by a vaccination program based on the H120 and CR88 commercial vaccines against a field variant of avian infectious bronchitis virüs. J Appl Poult Res. 23, 156–164.
  • Bronzoni RV, Fatima M, Montassier S, Pereira GT, Gama NM, Sakai V, Montassier HJ. (2005). Detection of infectious bronchitis virus and specific anti- viral antibodies using a Concanavalin A-Sandwich-ELISA. Viral Immunol.18, 569–578.
  • Cardoso WM, Aguiar JLC, Romao JM. (2005). Effect of Associated Vaccines on the Interference between Newcastle Disease Virus and Infectious Bronchitis Virus in Broilers. Brazilian J of Poultry Science. 3, 181–184.
  • Cardoso WM, Gomes LP, Romão JM, Salles RPR, Teixeira RSC, Sobral MHNR, Câmara SR, Oliveira WF. (2006). Antibodies specific to infectious bronchitis in broilers in Ceará state. Brazil Arq Bras Med Vet Zootec. 58(3), 327-332.
  • Cardoso WM, Gomes LP, Romão JM, Salles RPR, Teixeira RSC, Sobral MHNR, Câmara SR, Oliveira WF. (2006). Antibodies specific to infectious bronchitis in broilers in Ceará state, Brazil Arq. Bras Med Vet Zootec. 58(3), 327-332.
  • Cavanagh D, Davis PJ, Pappin DJ, Binns MM, Boursnell ME, Brown TD. (1986): Coronavirus IBV: partial amino terminal sequencing of spike polypeptide S2 identifies the sequence Arg-Arg-Phe-Arg-Arg at the cleavage site of the spike precursor propolypeptide of IBV strains Beaudette and M41. Virus Res. 4,133–143.
  • Cavanagh D, Davis PJ, Cook J. (1992): Infectious bronchitis virus: evidence for recombination within the Massachusetts serotype. Avian Pathol. 21, 401–408.
  • Cavanagh D. (1997). Nidovirales: A new order comprising Coronoviridae and Arteriviridae. Arch Virol. 142, 629–633.
  • Cavanagh D. & Naqi SA. (1997). Infectious bronchitis. In B.W. Calnek, H.J. Barnes, C.W. Beard, W.M. Reid & H.W. Yoder Jr. (Eds.), Diseases of Poultry 10th edn p. Ames, IA: Iowa State University Press. P. 511–526.
  • Cavanagh D. (2003). Severe acute respirarory syndrome vaccine development: experience of vaccination against avian infectious bronchitis coronovirus. Avian Pathol. 32(6), 567-582.
  • Cook JK, Davison TF, Huggins MB, McLaughlan P. (1991). Effect of in ovo bursectomy on the course of an infectious bronchitis virus infection in line C White Leghorn chickens. Arch Virol. 118, 225–34. Cook JK, Orbell SJ, Woods MA, Huggins MB. (1999). Breadth of protection of the respiratory tract provided by different live-attenuated infectious bronchitis vaccines against challenge with infectious bronchitis viruses of heterologous serotypes. Avian Pathol. 28(5), 477–85.
  • Cook JKA, Huggins MB, Orbell SJ, Mawditt K, Cavanagh D. (2001). Infectious bronchitis virus vaccine interferes with the replication of avian pneumovirus vaccine in domestic fowl. Avian Pathol. 30, 233-242.
  • Cook J. (2002). Coronaviridae. In: Jordan, F; Pattison, M; Alexander, D and Faragher, T (Eds.), Poultry diseases. (5th. Edn.), London,W. B. Saunders Co. P. 298-306.
  • Cook JKA. (2008). Coronaviridae. In: Pattison M, Bradbury A, editors. Poultry diseases. 6th ed. Amsterdam: Saunders Elsevier. p. 340-349.
  • Cook JKA, Jackwood M, Jones RC. (2012). The long view: 40 years of infectious bronchitis research. Avian Pathol. 41, 239–50.
  • de Herdt P, Ducatelle AR, Uyttebroek AE. (2001). Infectious bronchitis serology in broilers and broiler breeders: correlations between antibody titers and performance in vaccinated flocks. Avian Dis. 45, 612-619.
  • de Wit JJ, Cook JKA,Van Der Heijden HMJF. (2011). Infectious bronchitis virus variants: a review of the history, current situation and control measures. Avian Pathol. 40, 223–235.
  • Esendal MÖ. (2002). Enfeksiyöz Bronsitis, Kanatlı Hayvan Hastalıkları. Editörler: İzgür.M., Akan.M., Medisan Yayınları.50. Ankara, s: 155-162.
  • Gelb JJ, Nix WA, Gellman SD. (1998). Infectious bronchitis virus antibodies in tears and their relationship to immunity. Avian Dis. 42, 364–74.
  • Gelb JJr, Campion L, Ladman B. (2004). Interferência na replicação entre os vírus dabronquite infecciosa e da doença de Newcastle. In: Anais vol.1 da Conferência Apinco de Ciência e Tecnologias Avícolas. São Paulo-Brasil. p., 63-70.
  • Hamadan AM, Ghalyanchilangeroudia A, Hashemzadehb M, Hosseinic H, Karimid V, Yahyaraeyata R, Najafia H. (2017). Genotyping of Avian infectious bronchitis viruses in Iran (2015–2017) reveals domination of IS-1494 like virus. Virus Res. 240, 101-106.
  • Ignjatovic J Galli L. (1994). The S1 glycoprotein but not the N or M proteins of avian infectious bronchitis virus induces protection in vaccinated chickens. Archives of Virol. 138, 117–134.
  • Ignjatovic J & Sapats S. (2000). Avian infectious bronchitis virus. Révue Scientifique et Technique (Office Internationaldes Epizooties). 19, 493–508.
  • Jackwood MW, Hilt DA, Brown TP. (2003). Attenuation, safety, and efficacy of an infectious bronchitis virus GA98 serotype vaccine. Avian Dis. 47(3), 627–32.
  • Jackwood MW. (2010). Control of Arkansas infectious bronchitis virus by vaccination. Avian Insight. 3, 1–4.
  • Jia W, Karaka K, Parrish CR. (1995). A novel variant of avian infectious bronchitis virus resulting from recombination among three different strains. Arch Virol. 140, 259-271.
  • Kahya S, Çöven F, Temelli S, Eyigör A, Çarlı KT. (2013). Presence of IS/1494/06 genotype-related infectious bronchitis virus in breeder and broiler flocks in Turkey. Ankara Üniv Vet Fak Derg. 60,27-31.
  • Karimi V, Ghalyanchilangeroudi A, Hashemzadeh M, Rahimi F, Petroudi MTZ, Farahani RKH, Maghsoudloo H, Abdollahi H, (2018). Efficacy of H120 and Ma5 avian infectious bronchitis vaccines in early challenge against QX strain. Virus Dis. 29(1),123–126.
  • Lee CW, Jackwood MW. (2000): Evidence of genetic diversity generated by recombination among avian coronovirus IBV. Arch Virol. 145, 2135–2148.
  • Marcin S, Bartlomiej T, Daria D, Tomasz S, Andrzej K. (2017). Immunological aspects of the efficiency of protectotype vaccination strategy against chicken infectious bronchitis. BMC Veterinary Res. 13, 44.
  • Matthijs MGR, Van Eck JHH, Landman WJM, Stegeman JA. (2003). Ability of Massachusetts-type infectious bronchitis virus to increase colibacillosis susceptibility in commercial broilers: A comparison between vaccine and virulent field virus. Avian Pathol.32, 473–481.
  • McKinley ET, Hilt DA, Jackwood MW. (2008). Avian coronavirus infectious bronchitis attenuated live vaccines undergo selection of subpopulations and mutations following vaccination. Vaccine. 26, 1274– 1284.
  • OIE. Manual of standards for diagnostic tests and vaccines. Office International des Epizooties, World Organisation for Animal Health, Paris. 2000. www.oie.int Erişim Ağustos 2020)
  • Okino CH, Alessi AC, Montassier MDFS, Rosa AJDM, Wang X, Montassier HJ. (2013). Humoral and cell-mediated immune responses to different doses of attenuated vaccine against avian infectious bronchitis virus. Viral Immunol. 26(4),259–67 .
  • Okino CH, dos Santos IL, Fernando FS, Alessi AC, Wang X, Montassier HJ. (2014). Inflammatory and cell-mediated immune responses in the respiratory tract of chickens to infection with avian infectious bronchitis virus. Viral Immunol. 27, 383–9.
  • Otsuki K, Huggins MB, Cook JKA. (1990). Comparison of the susceptibility to avian infectious bronchitis virus infection of two inbred lines of white leghorn chickens. Avian Pathol. 19, 467–475.
  • Roussan DA, Totanji WS, Khawaldeh GY. (2008). Molecular subtype of infectious bronchitis virus in broiler flocks in Jordan. Poult Sci. 87, 661–664.
  • Shapouri S, Mayahi MR, Asasi MK, Charkhkar S. (2004). A survey of the prevalence of infectious bronchitis virus type 4.91 in Iran. Acta Vet Hungarica. 52, 163–166.
  • van Ginkel FW, van Santen VL, Gulley SL, Toro H. (2008). Infectious bronchitis virus in the chicken Harderian gland and lacrimal fluid: Viral load, infectivity, immune cell responses, and effects of viral immunodeficiency. Avian Dis. 52, 608–17
There are 48 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Sciences
Journal Section Original Article
Authors

Gülşen Goncagül 0000-0003-4331-9698

Özlem Kardoğan This is me 0000-0002-6457-3292

Elçin Günaydın This is me 0000-0002-5247-7578

Publication Date December 31, 2020
Submission Date September 17, 2020
Published in Issue Year 2020 Volume: 31 Issue: 2

Cite

APA Goncagül, G., Kardoğan, Ö., & Günaydın, E. (2020). İç Anadolu’da enfeksiyöz bronşit virüsü aşılamasının etkinliği. Etlik Veteriner Mikrobiyoloji Dergisi, 31(2), 147-153. https://doi.org/10.35864/evmd.796390

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