Pathogenicity and immunity in Escherichia coli infections

Year 1988, Volume: 6 Issue: 3, 229 - 240, 01.12.1988

Osman Erganiş Mehmet Ateş Osman Kaya Ersin İstanbulluoğlu

Abstract

The Importance of E.coli as a pathogen has been known for many years. Virulence factors of E.coli such as the ability to produce toxin, to resist the immune defenses of the host, and to locate and colonize the appropriate tissues by specific adhesins can not be attributed to a single determinant. Therefore presence of enterotoxigenic or enteropathogenic E.coli strains in diarrheic young animals should be confirmed by laboratory diagnostics based on enteropatohogenicity and colonization factors. Recently, the presence of specific fimbriae (K99, K88, 987p, CFA/I, CSI, CSII, CSIII, F41, Type-1) in pathogenic E.coli strains has been found to be significantly correlated with pathogenicity. The fimbria confers on pathogenic isolates the ability to adhere and to colonize various specific host epithelia and are strongly immunogenic. The methods have been developed to stimulate immunity by vaccination of dams.

Escherichia coli Enfeksiyonlarında Patojenite ve İmmunite

Abstract

Escherichia coli'nin bir patojen olarak önemi yıllardır bilinmektedir. E.coli'nin toksin üretme yeteneği, konakçının savunma sistemlerine direnme ve spesifik adhezinleriyle uygun dokulara tutunma ve kolonize olma gibi virülens faktörleri tek bir determinanta bağlanamaz. Bu yüzden ishalli genç hayvanlarda enterotoksijenik veya enteropatojenik E.coli'lerin varlığı enteropajenite ve kolonizasyon faktörlerini temel alan laboratuvar teşhis metodları ile doğrulanmalıdır. Son yıllardar patojenik E.coli suşlarında spesifik fimbriaların (K99. K88, 987p, CFA/I, CSI, CSII, CSIII, F41, Tip-1)varlığı, patojenite ile doğrudan ilişkili bulunmuştur. Fimbrialar patojenik suşların muhtelif spesifik konakçı epitellerine tutunma ve kolonize olmalarını sağlar ve güçlü immunojeniktirler. Bu özellikten hareketle gebe hayvanların aşılanmasına yönelik metotlar geliştirilmiştir.

Keywords

Escherichia coli, Escherichia Coli Enfeksiyonları, Escherichia Coli Enfeksiyonlarında Patojen, Escherichia Coli Enfeksiyonlarında İmmunite, Etlik Veteriner Mikrobiyoloji Dergisi, 1987, 1988, Osman ERGANİŞ, Mehmet ATEŞ, Osman KAYA, Ersin İSTANBULLUOĞLU

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