The experimental study on heparin, streptokinase, Vitamin-e and selenium for the prevention Of intraabdominal adhesions in rabbits

Year 1996, Volume: 8 Issue: 3, 114 - 127, 01.12.1996

Zeki Alkan Ali Bumin Yaşar Şeker Tolga Güvenç

Abstract

Adhesions are abdominal connections between peritoneal surfaces. Postoperative
peritoneal adhesions continue to be a serious surgical problem various
methods have been tried with lirriited success to reduce the ineidence of
peritoneal adhesions. These methods as the prevention of fibrin depositian in
the postoperative period, the removal of the fibrinous exudate, which follows
any surgical procedure by peritoneal surfaces and the inhibition of fibroblast
proliferation using cytotoxic agents, antihistamines and steroids. In this study,
40 unit/kg heparİn or 90.000 IU/kg streptokinase were applied intraabdominally
4 times with 12 hours intervals, vitamin-E 300 mg/kg or sodium selenit 0.5 mg/
kg IM 24 hours preoperativeiy, peroperatively and 24 hours postoperatively. All
these methods found to be meaninigful better than control gruoups.

Tavşanlarda İntraabdominal Adezyonların Önlenmesinde Heparin, Streptokinaz, Vitamin-E ve Selenyum Kullanılması Üzerine Deneysel Çalışmalar

Abstract

Adezyonlar, periton yüzeyleri arasında oluşan anormal birleşmelerdir.
Operasyon sonrası perİtonal yapışmalar, ciddi bir cerrahi problem olarak ortaya
çıkar. Sınırlı başanya sahip değişik metotlar, perİtonal adezyonlann oluşumunu
azaltmak için denenmiştir.Bu metotlar, postoperatif olarak şekillenen fibrinöz eksudatın proteolitik enzimlerle lavajı, steroidler, antihistaminikler ve sitotoksik ajanlar kullanılarak
fibroblastik aktivasyonun inhibisyonu ve perİtonal yüzeylerin mekanik olarak
ayrılması şeklinde sınıflandınlmıştır.
Bu çalışmada, heparin'in 40 ünite/kg ve streptokinaz'ın 90.000 İU/kg
intraperitonal olarak ı2 saat ara ile 4 kez, vitaminE'nin 300 mg/kg ve Sodyum
selenit'in 0.5 mg/kg olarak operasyondan 24 saat önce, operasyon sonrası ve
24 saat sonra olmak üzere kas içi uygulanması ile kontrol grubuna oranla başarılı
sonuçlar alınmıştır.

Keywords

Tavşan, İntraabdominal Adezyonlar, Heparin, Streptokinaz, Vitamin-E, Selenyum, Zeki ALKAN, Ali BUMİN, Yaşar ŞEKER, Tolga GÜVENÇ

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