Tüberculosis Cases In Two Monkeys

Year 1996, Volume: 8 Issue: 4, 47 - 58, 01.12.1996

M. Müfit Kahraman Figen Kahraman

Abstract

Tuberculosis casesin two Old Wold monkeys, from the zoos oftwo different
cities in Turkey, submitted for necropsy to the Department of Pathology Veterinary. Faculty, Uludag University (Case 1) and Bursa, City Control Laboratory
(Case 2) were exarnined. White in one ofthe monkeys (Case 1) Mycobacterium
tuberculosis was isolated and identifıed, in the other (Case 2) isolation
of the Mycobacterium s pp. was made, yet identifıcation was not accomplished.
Macroscopically, in both cases, subpleural and parenchymatous grey to
white, miliary, disseminated nodules in the lungs \vere observed. Bronchial lymph
nodes contained similar nodules. Tuberculotic lesions of the li ver were observed
in Case 1 only, yet spleen and kidneys had been affected in both cases. Neither
in Case I nor in case two, no tuberculotic lesions were seen in the intertines,
mesenteric lymph nodes, cerebrum, bones, and the skin. Tubercles were either
in s ing! e or conglomerated appearance microscopically, and generally composed
of necrosis, epithelioid cells, Langhans type giant cells, and surraunding connective
tissue. Caseation of the tubercles were only observed in the spleen.
In the choroid and retina ofthe left eye of the case 1, cell infıltrations with
epithelioid cells and few giant cells were not evaluated as tuberculotic lesions
since they were not in the fonn of tu bere! e and also did not contain acid-tast
bacteria in Ziehl-Neelsen stain.
In both cases, with Ziehl-Neelsen stain, acid-fast bacteria being more abundant
in the lungs, kidneys and spleen \.vere observed.

İki Maymunda Görülen Tüberküloz Olgusu

Abstract

Farklı iki ilimizin hayvanat bahçelerinden U. Ü. Veteriner Fakültesi Patoloji
Anabilim Dalı 'na (Olgu ı) ve Bursa il Kontrol Laboratuvar Müdür! üğü ' ne (O lg u
2) nekropsi için getirilen iki Eski Dünya maymunundaki tüberküloz olgusu
incelenmiştir. Bir maymundan (Olgu I) Mycobacterium spp. İzolasyonu yapılmış
ancak, identifıkasyon gerçekleştirilememiştir. Makroskobik olarak her iki
maymunun akcigerinde subplöyral ve parankimatöz, boz-beyaz renkli, milier,
dissemine nodüller görülmüş , bronşiyal lenf nodüllerinde de tüberküller
saptannuştır. Sadece, birinci olgumm karaciğerinde tüberküloz lezyonlan görülmüş ,dalak ve böbreklerdeki Iezyonlara ise her iki olguda da rastlanmıştır.Barsak,mezenteriyel lenf yumruları, beyin, kemik ve deride her iki maymuncia da lezyongörülemeıniştir. Tüberküller tek veya konglomere olup, nekroz, epiteloid hücreler,Langhans tipi dev hücreleri ve bağ doku kuşağındanoluşmuştur. Kazeifıkasyonayalnızca 1. olgunun dalagında rastlanmıştır.
Birinci olgunun sol gözünün koroid ve retina tabakalarında göriilen epiteloid
histiyosit ve az sayıdaki dev hücre infiltrasyonları tipik tüberkül yapısında
olmadığından ve Ziehl-Neelsen tekniği ile yapılan boyama negatif sonuç
verdiğinden tüberküloz lezyonu olarak değerlendirilmemiştir.
Ziehl-Neelsen tekniği ile yapılan boyaınada, her iki olguda akciğerlerde yoğun
olmak üzere, böbrek ve dalaktaki tüberküllerde çomak şeklinde, aside-dirençli
mikroorganizma! ara rastlanmıştır.

Keywords

Maymun, Tüberküloz, M. Müfit KAHRAMAN, Figen KAHRAMAN, 1996, Etlik Veterinerlik Mikrobiyoloji Dergisi, Mycobacterium spp.

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