Farelerde İvermektinle Zehirlenmelerde Sağaltım Denemeleri
Yıl 1996,
Cilt: 8 Sayı: 4, 131 - 136, 01.12.1996
Ali Bilgili
Sezai Kaya
Ender Yarsan
Öz
Bu çalışınada 0.8-30 mg/kg arasında değişen miktarlarda farelere verilenivennektinle zehirlennıe hallarinde kafein ve neostigminin klinik olarak antidotal etkisi incelendi. Deri altı yoll<\ kafein 10 mg/kg ve neostigınin 0.025 mg/kgdozlarda uygulandı. Denemeler sonucunda kafeinin daha etkili olduğu sonucuna varıldı.
Kaynakça
- ALABAY, M. ( 1982): Veteriner hekiınlikte avennektinler ve bunların etki alanları .
Vet.Hek.Dem.Derg. 42(2):37-42.
- AMDUR,M.AAT ALL (1991): CaserettandDoull'sToxicology. 4tl'Ed. Pergaınon
Press, Ine. New York, USA.
- BENZ. G.W. AND ERNST, J.V. (1981): Anthelmintic efficacy of 22,23-
dihidroavermectin B1 (I vermeeti n) against gastrointestinal nematades in calves. Amer.
J.VetRes. 42:1409-1411.
- CAMPBELL, W. C. AND BLAIR, LS. ( 1978): Efficacy of avennectins against
Drofilaria immilis in dog. J.Helminthol. 52:308-310.
- EAGLESON, J.S. AND ALLERTON, G.R. (1992): Efficacy and safety of
iverınectin applied topically to cattle under field conditions in Australia. Aust. Vet.
69(6): 133-134.
- EGERTON, J.R., AT ALL (1979): Avennectins, newfamily ofpotent anthelmin tic
agents: efficacy oftheB1, component. Antimicrob. Agents. Chemother. 15 :372-378.
- GOODMAN, G. AT ALL (1991): Goodman and Gilman's The Phannacological
Basis ofTherapeutics 8tl'Ed. Pergamon Press, Ine/New York, USA.
- Kll.,GORE, R.L. AT ALL (1983): Response of horses to repeated intraınuscular injections ofivennectin. Vet.Med.Sınall.Aniın. C lin. 78: 1894-1897.
- KURTDEDE, A. VE ARK. (1992) : Köpeklerde deneysel iverınektin
toksikasyonunda picrotoxin kullarunu. Ankara Üniv. Vet.Fak.Derg. 39(1-2):20 1-206.
- KURTDEDE, A VE ARK. (1 990): Köpeklerde deneysel ivennektin toksikasyonu.
Ankara Üniv.\et.Fak.Derg. 37(3):5:9-608.
- LYONS, E. T. AT ALL (1980): Antiparasi tic activity ofivennectin in critical tesıs
inequids. Aıner. J.Vet.Res. 41 :2069-2072.
- MAN GER, B.R ( 1992): Antlıelmintics 413-548. Veterinary Applied Phannacology
and Therapeutics. Fifth Edition In: G.C. Brander, D.M.Pugh, R.J.Bywater and
W.L.Jenkins (Eds). Bailliere Tindall, London.
- MELLIN, T.N. AT ALL (1983): Postsynaptic inhibition ofinvertebrate neuromuscular transmission by avermectin B,._ Neuropharmacology. 22:89-96.
- OSTLIND, D.A. AT All (1979): Insecticidal activity of the antiparasİtic
avermectins. Vet.Rec. 105 :168.
- . PLUMB, D. C. (1991): Veterinary Drug Handbook. Pocket Edition. Pharma Vet
Publishing, USA.
PONG, S.S. AND WANG, C.C (1982): AvennectinB,.ınodulationofgaınınaaminobutyric
acid receptors in rat brain membranes. J.Neurochem. 38:375-379.
- ROBERSON, E.L. (1988): Chemotherapy of parasitic diseases: Introduction
and antinematodal drugs. 877-92 7. In :M. H.Bootlı and L.E.Mc Donald(Eds): In: Veterinary
Phannacology and Therapeutics. 6th Edi tion. Iowa State Universty Press, Ames,
Iowa.
- SEWARD, RL. (1983): Reactions in doggiven ivennectin. J.Amer. Vet. Med.
Assoc. 183:493.
- KAYA, S. (1994). Spesiyalitelerin kısa taıuını . 41-356. İçinde:Y. Şanlı ve S.Kaya
(1994). Veteriner İlaç Rehberi ve Uygulaınalı Bilgiler El Kitabı. Medisan Yayı nevi, Yayın
No 15, Ankara
Therapeutic Applications In Ivermect In Poisoning Mice
Yıl 1996,
Cilt: 8 Sayı: 4, 131 - 136, 01.12.1996
Ali Bilgili
Sezai Kaya
Ender Yarsan
Öz
In this study, antidotal effects of caffeine and neostigmine were investigated clinically in mice poisoned with ivermectin usedin doses of0.8 to 30 mg/kg body weight. Caffeine and neostigmine were given subcutaneously at dose level of 10 mg/kg and neostigmine 0.025 mg/kg body weight respectively. It was concluded from the experiments that caffeine was more effective than neostigmine
Kaynakça
- ALABAY, M. ( 1982): Veteriner hekiınlikte avennektinler ve bunların etki alanları .
Vet.Hek.Dem.Derg. 42(2):37-42.
- AMDUR,M.AAT ALL (1991): CaserettandDoull'sToxicology. 4tl'Ed. Pergaınon
Press, Ine. New York, USA.
- BENZ. G.W. AND ERNST, J.V. (1981): Anthelmintic efficacy of 22,23-
dihidroavermectin B1 (I vermeeti n) against gastrointestinal nematades in calves. Amer.
J.VetRes. 42:1409-1411.
- CAMPBELL, W. C. AND BLAIR, LS. ( 1978): Efficacy of avennectins against
Drofilaria immilis in dog. J.Helminthol. 52:308-310.
- EAGLESON, J.S. AND ALLERTON, G.R. (1992): Efficacy and safety of
iverınectin applied topically to cattle under field conditions in Australia. Aust. Vet.
69(6): 133-134.
- EGERTON, J.R., AT ALL (1979): Avennectins, newfamily ofpotent anthelmin tic
agents: efficacy oftheB1, component. Antimicrob. Agents. Chemother. 15 :372-378.
- GOODMAN, G. AT ALL (1991): Goodman and Gilman's The Phannacological
Basis ofTherapeutics 8tl'Ed. Pergamon Press, Ine/New York, USA.
- Kll.,GORE, R.L. AT ALL (1983): Response of horses to repeated intraınuscular injections ofivennectin. Vet.Med.Sınall.Aniın. C lin. 78: 1894-1897.
- KURTDEDE, A. VE ARK. (1992) : Köpeklerde deneysel iverınektin
toksikasyonunda picrotoxin kullarunu. Ankara Üniv. Vet.Fak.Derg. 39(1-2):20 1-206.
- KURTDEDE, A VE ARK. (1 990): Köpeklerde deneysel ivennektin toksikasyonu.
Ankara Üniv.\et.Fak.Derg. 37(3):5:9-608.
- LYONS, E. T. AT ALL (1980): Antiparasi tic activity ofivennectin in critical tesıs
inequids. Aıner. J.Vet.Res. 41 :2069-2072.
- MAN GER, B.R ( 1992): Antlıelmintics 413-548. Veterinary Applied Phannacology
and Therapeutics. Fifth Edition In: G.C. Brander, D.M.Pugh, R.J.Bywater and
W.L.Jenkins (Eds). Bailliere Tindall, London.
- MELLIN, T.N. AT ALL (1983): Postsynaptic inhibition ofinvertebrate neuromuscular transmission by avermectin B,._ Neuropharmacology. 22:89-96.
- OSTLIND, D.A. AT All (1979): Insecticidal activity of the antiparasİtic
avermectins. Vet.Rec. 105 :168.
- . PLUMB, D. C. (1991): Veterinary Drug Handbook. Pocket Edition. Pharma Vet
Publishing, USA.
PONG, S.S. AND WANG, C.C (1982): AvennectinB,.ınodulationofgaınınaaminobutyric
acid receptors in rat brain membranes. J.Neurochem. 38:375-379.
- ROBERSON, E.L. (1988): Chemotherapy of parasitic diseases: Introduction
and antinematodal drugs. 877-92 7. In :M. H.Bootlı and L.E.Mc Donald(Eds): In: Veterinary
Phannacology and Therapeutics. 6th Edi tion. Iowa State Universty Press, Ames,
Iowa.
- SEWARD, RL. (1983): Reactions in doggiven ivennectin. J.Amer. Vet. Med.
Assoc. 183:493.
- KAYA, S. (1994). Spesiyalitelerin kısa taıuını . 41-356. İçinde:Y. Şanlı ve S.Kaya
(1994). Veteriner İlaç Rehberi ve Uygulaınalı Bilgiler El Kitabı. Medisan Yayı nevi, Yayın
No 15, Ankara