Case Report
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İneklerde kronik (izole) organ tüberkülozunun patomorfolojik ve immünohistokimyasal değerlendirilmesi

Year 2022, Volume: 33 Issue: 1, 97 - 101, 15.06.2022
https://doi.org/10.35864/evmd.995158

Abstract

Olguyu patomorfolojik ve immünhistokimyasal olarak ortaya koymayı amaçladık. Bu raporda geç dönemde bir sığırda gelişen kronik, izole organ tüberkülozuna ait genel bulgular sunulmuştur. Vakanın öyküsünde 2 yaşındaki sığır solunum sıkıntısı sonucu ölmüş olup ölüm nedeninin tespiti için patoloji laboratuvarına getirilmiştir. Nekropside, sağ akciğerin kaudal lobunda lokalize kapsüllenmiş kazeöz odaklar ile mediastinal lenf düğümlerinin inaktif olduğu tespit edildi.
Histopatolojik olarak mineralize olmayan, sekonder kazeöz nekroz, periferal mononükleer hücre infiltrasyonu ve fibröz kapsül tespit edildi. İmmünohistolojik olarak, bazı makrofajlar ve nötrofillerin Mycobacterium bovis açısından pozitif olduğu görüldü. Ancak bölgesel lenf düğümleri negatifti. Ayrıca, diğer parankimatöz organlarda histopatolojik reaksiyon yoktu. Sonuç olarak, postprimer tüberküloz formu, diğer formlarla karşılaştırıldığında her zaman tespit edilemez. Bu nedenle, bu olgu raporunun yararlı olabileceğine inanıyoruz.
Anahtar kelimeler: İnek, kronik organ tüberkülozu, immünolojik tespit, patomorfoloji.

Supporting Institution

DESTEK ALINMAMIŞTIR.

Project Number

PROJE DEĞİLDİR.

References

  • Referans1 Arentz M, Hawn TR, (2007). Tuberculosis infection: insight from immunogenomics. Drug Discovery Today: Disease Mechanisms, 4(4), 231-236.
  • Referans2 Buddle BM, Aldwell FE, Pfeffer A, Lisle GD, Corner LA, (1994). Experimental Mycobacterium bovis infection of cattle: effect of dose of M. bovis and pregnancy on immune responses and distribution of lesions. New Zealand Veterinary Journal, 42(5), 167-172.
  • Referans3 Buddle BM, De Lisle GW, Pfeffer A, Aldwell FE, (1995). Immunological responses and protection against Mycobacterium bovis in calves vaccinated with a low dose of BCG. Vaccine, 13(12), 1123-1130.
  • Referans4 Domingo M, Vidal, E, Marco A. (2014). Pathology of bovine tuberculosis. Research in veterinary science, 97, S20-S29.
  • Referans5 McIlroy SG, Neill SD, McCracken RM, (1986). Pulmonary lesions and Mycobacterium bovis excretion from the respiratory tract of tuberculin reacting cattle. The Veterinary Record, 118(26), 718-721.
  • Referans6 Messow C, (1991). Respirationapparat. Shulz C. (ed.). Pathologie der Haustiere Teil I. 1ste verlauf. p.:193-194. Referans7 Neill SD, Bryson DG, Pollock JM, (2001). Pathogenesis of tuberculosis in cattle. Tuberculosis, 81(1-2), 79-86.
  • Referans8 Neill SD, Hanna J, O'brien JJ, McCracken RM, (1988). Excretion of Mycobacterium bovis by experimentally infected cattle. The Veterinary Record, 123(13), 340-343.
  • Referans9 Neill SD, Pollock JM, Bryson DB, Hanna J, (1994). Pathogenesis of Mycobacterium bovis infection in cattle. Veterinary microbiology, 40(1-2), 41-52.
  • Referans10 O'Reilly LM, Daborn CJ, (1995). The epidemiology of Mycobacterium bovis infections in animals and man: a review. Tubercle and Lung disease, 76, 1-46.
  • Referans11 Phillips CJC, Foster CRW, Morris PA, Teverson R, (2003). The transmission of Mycobacterium bovis infection to cattle. Research in veterinary science, 74(1), 1-15.
  • Referans12 Wangoo A, Johnson L, Gough J, Ackbar R, Inglut S, Hicks D, Spencer Y, Hewinson G, Vordermeier M, (2005). Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, γδ (WC1+) T cells and CD 68+ cells. Journal of comparative pathology, 133(4), 223-234.

Pathomorphological and immunohistochemical evaluation of chronic (isolated) organ tuberculosis in a cow

Year 2022, Volume: 33 Issue: 1, 97 - 101, 15.06.2022
https://doi.org/10.35864/evmd.995158

Abstract

We aimed to reveal the case pathomorphological and immunohistochemically. General findings of chronic isolated organ tuberculosis in cattle in the late period are presented in this report. In the history of the case, the 2-year-old cattle died as a result of respiratory distress and was brought to the pathology laboratory to determine the cause of death. In necropsy, it was detected that encapsulated caseous foci localized in the caudal lobe of the right lung and mediastinal lymph nodes were inactive. Histopathologically, non-mineralized, secondary caseous necrosis, peripheral mononuclear cell infiltration, and fibrous capsule were detected. Immunohistologically, some macrophages and neutrophils were found to be positive for Mycobacterium bovis. However, regional lymph nodes were negative. Also, there was no histopathological reaction in other parenchymatous organs. As a result, the postprimary form of tuberculosis is not always detectable when compared to other forms. Therefore, we believe that this case report may be useful.
Keywords: Cow, chronic organ tuberculosis, immunological detection, pathomorphology.

Project Number

PROJE DEĞİLDİR.

References

  • Referans1 Arentz M, Hawn TR, (2007). Tuberculosis infection: insight from immunogenomics. Drug Discovery Today: Disease Mechanisms, 4(4), 231-236.
  • Referans2 Buddle BM, Aldwell FE, Pfeffer A, Lisle GD, Corner LA, (1994). Experimental Mycobacterium bovis infection of cattle: effect of dose of M. bovis and pregnancy on immune responses and distribution of lesions. New Zealand Veterinary Journal, 42(5), 167-172.
  • Referans3 Buddle BM, De Lisle GW, Pfeffer A, Aldwell FE, (1995). Immunological responses and protection against Mycobacterium bovis in calves vaccinated with a low dose of BCG. Vaccine, 13(12), 1123-1130.
  • Referans4 Domingo M, Vidal, E, Marco A. (2014). Pathology of bovine tuberculosis. Research in veterinary science, 97, S20-S29.
  • Referans5 McIlroy SG, Neill SD, McCracken RM, (1986). Pulmonary lesions and Mycobacterium bovis excretion from the respiratory tract of tuberculin reacting cattle. The Veterinary Record, 118(26), 718-721.
  • Referans6 Messow C, (1991). Respirationapparat. Shulz C. (ed.). Pathologie der Haustiere Teil I. 1ste verlauf. p.:193-194. Referans7 Neill SD, Bryson DG, Pollock JM, (2001). Pathogenesis of tuberculosis in cattle. Tuberculosis, 81(1-2), 79-86.
  • Referans8 Neill SD, Hanna J, O'brien JJ, McCracken RM, (1988). Excretion of Mycobacterium bovis by experimentally infected cattle. The Veterinary Record, 123(13), 340-343.
  • Referans9 Neill SD, Pollock JM, Bryson DB, Hanna J, (1994). Pathogenesis of Mycobacterium bovis infection in cattle. Veterinary microbiology, 40(1-2), 41-52.
  • Referans10 O'Reilly LM, Daborn CJ, (1995). The epidemiology of Mycobacterium bovis infections in animals and man: a review. Tubercle and Lung disease, 76, 1-46.
  • Referans11 Phillips CJC, Foster CRW, Morris PA, Teverson R, (2003). The transmission of Mycobacterium bovis infection to cattle. Research in veterinary science, 74(1), 1-15.
  • Referans12 Wangoo A, Johnson L, Gough J, Ackbar R, Inglut S, Hicks D, Spencer Y, Hewinson G, Vordermeier M, (2005). Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, γδ (WC1+) T cells and CD 68+ cells. Journal of comparative pathology, 133(4), 223-234.
There are 11 citations in total.

Details

Primary Language English
Subjects Veterinary Sciences
Journal Section Case Reports
Authors

Yavuz Ulusoy 0000-0001-6942-5013

Bahadır Kılınç 0000-0003-3426-2116

Halil Pir 0000-0001-9078-3122

Funda Terzi 0000-0002-6184-5408

Orhan Dudaklı 0000-0001-9598-8055

Project Number PROJE DEĞİLDİR.
Early Pub Date June 24, 2022
Publication Date June 15, 2022
Submission Date September 14, 2021
Published in Issue Year 2022 Volume: 33 Issue: 1

Cite

APA Ulusoy, Y., Kılınç, B., Pir, H., Terzi, F., et al. (2022). Pathomorphological and immunohistochemical evaluation of chronic (isolated) organ tuberculosis in a cow. Etlik Veteriner Mikrobiyoloji Dergisi, 33(1), 97-101. https://doi.org/10.35864/evmd.995158

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