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Canine Babesiosis

Yıl 2011, Cilt: 22 Sayı: 2, 74 - 78, 29.12.2011

Öz

Canine babesiosis is a tick-borne disease caused by the protozoal parasites Babesia gibsoni and Babesia canis. These parasites infect the red blood cells of dogs and typically cause hemolytic anemia. B.canis belongs to large babesias and is classified in three subspecies B.canis canis, B.canis rossi and B.canis vogeli. Although they share a similar morphology, they have different vector specificity (Dermacentor reticulatus, Haemaphysalis laechi and Rhipicephalus sanguineus respectively), geographical distribution, antigenicity and pathogenicity to dogs. Infection with B.gibsoni generally results in more severe clinical manifestations than infection with B.canis, and may cause multiple organ dysfunctions. In recent years molecular studies it was found small and large babesias in dogs are more than adopted.

Kaynakça

  • Aboge GO, Jia H, Terkawi MA, Goo Y, Kuriki K, Nishikawa Y, Igarashi I, Suzuki H, Xuan X, (2007). A novel 57-kDa merozoite protein of Babesia gibsoni is a prospective antigen for diagnosis and serosurvey of canine babesiosis by enzyme-linked immunosorbent assay. Vet Parasitol. 149, 85-94.
  • Anderson JF, Magnarelli LA, Sulzer AJ, (1980). Canine babesiosis: ındirect fluorescent antibody test for a North American isolate of Babesia gibsoni. Am J Vet Res. 41, 2102-2105.
  • Aysul N, (2006). İstanbul ili köpeklerinde bulunan babesia türlerinin teşhisinde mikroskobik ve PCR-RLB bulgularının karşılaştırılması. Doktora Tezi,.İ.Ü. Sağlık Bilimleri Enstitüsü, İstanbul.
  • Aysul N, Ural K, Ulutaş B, Eren H, Karagenç T, (2009). Aydın ilinde bir köpekte Babesia gibsoni olgusu. 16. Ulusal Parazitoloji Kongresi Poster bildirisi. Adana.
  • Birkenheuer AJ, Levy MG, Breitschwerdt EB, (2003). Development and evaluation of a seminested PCR for detection and differentiation of Babesia gibsoni (Asian genotype) and B. canis DNA in canine blood samples. J Clin Microbiol. 41, 72-77.
  • Birkenheuer AJ, Neel J, Ruslander D, Levy MG, Breitschwerdt EB, (2004). Detection and molecular characterization of a novel large Babesia species in a dog. Vet Parasitol. 124, 151-160.
  • Birkenheuer AJ, Correa MT, Levy MG, Breitschwerdt EB, (2005). Geographic distribution of babesiosis among dogs in the United States and association with dog bites: 150 cases (2000-2003). J Am Vet Med Assoc. 227, 942-947.
  • Blood DC, Otto MR, Gay CC, Radostits OM, (1994). A Textbook of the diseases of cattle, sheep, pigs, goats and horses. 7nd ed. London: Veterinary Medicine Bailliere Tindall.
  • Böhm M, Leisewitz AL,Thompson PN, Schoeman JP, (2006). Capillary and venous Babesia canis rossi parasitaemias and their association with outcome of infection and circulatory compromise. Vet Parasitol. 141, 18-29.
  • Camacho AT, Guitian FJ, Pallas E, Gestal JJ, Olmeda AS, Goethert HK, Telford III SR, Spielman A, (2004). Azotaemia and mortality among Babesia-microti-like infected dogs. J Vet Int Med. 18, 141-146.
  • Carret C, Walas F, Carcy B, Grande N, Precigout E, Moubri K, Schetters PT, Gorenflot A, (1999). Babesia canis canis, Babesia canis vogeli, Babesia canis rossi: differentiation of the three subspecies by a restriction fragment length polymorphism analysis on amplified small subunit ribosomal RNA genes. J Eukaryot Microbiol. 46, 298-303.
  • Conrad P, Thomford J, Yamane I, Whiting J, Bomsa L, Uno T, Holshuh HJ, Shelly S, (1991). Hemolytic anemia caused by Babesia gibsoni infection in dogs. J Am Vet Med Assoc. 199, 601-605.
  • Criado-Fornelio A, Martinez-Marcos A, Buling-Sarana A, Barba-Carretero JC, (2003). Molecular studies on Babesia, Theileria and Hepatozoon in southern Europe. Part I. Epizootiological aspects. Vet Parasitol. 113, 189-201.
  • Fukumoto S, Xuan X, Shigeno S, Kimbita E, Igarashi I, Nagasawa H, Fujisaki K, Mikami T, (2001) . Development of a polymerase chain reaction methods for diagnosing Babesia gibsoni infection in dogs. J Vet Med Sci. 63, 977-981.
  • Georges K, Ezeokoli CD, Newaj-Fyzul A, Campbell M, Mootoo N, Mutani A, Sparagano OAE, (2008). The application of PCR and reverse line blot hybridization to detect arthropod-borne haemopathogens of dogs and cats in Trinidad. Ann N Y Acad Sci. 1149, 196-199.
  • Goo Y, Jia H, Aboge GO, Terkawi MA, Kuriki K, Nakamura C, Kumagai A, Zhou J, Lee EG, Nishikawa Y, (2008). Babesia gibsoni: Serodiagnosis of infection in dogs by an enzyme-linked immunosorbent assay with recombinant BgTRAP. Exp Parasitol. 118, 555-560.
  • Gören S, Yetkin R, (1935). Tektırnaklıda, sığırda, koyunda, keçide ve köpekte piroplasmoz. M.M.B. Bakt. Evi Yayını.Ulus Basımevi,.Ankara. 104 s.
  • Gülanber A, Gorenflot A, Schetters TP, Carcy B, (2006). First molecular diagnosis of Babesia vogeli in domestic dogs from Turkey. Vet Parasitol. 139, 224-230.
  • Irwin PJ, Hutchinson GW, (1991). Clinical and pathological findings of Babesia infection in dogs. Aust Vet J: 68, 204-209.
  • Irwin PJ, (2009). Canine babesiosis: from molecular taxonomy to control. Parasites and Vectors. Erişim adresi: (http://www.parasitesandvectors.com/content/2/S1/S4) Erişim tarihi: 27. 03. 2009.
  • Jefferies R, Ryan U, Irwin P, (2007). PCR-RFLP for the detection and differentiation of the canine piroplasm species and its use with filter paper-based technologies.Vet Parasitol. 144, 20-27.
  • Kırlı G, (2006). Ege Bölgesi’nde köpek Babesiosis’inin yaygınlığı. Yüksek Lisans Tezi ADÜ. Sağlık Bilimleri Enstitüsü, Aydın.
  • Kjemtrup AM, Wainwright K, Miller M, Penzhorn BL, Carreno RA, (2006). Babesia conradae, sp. nov., a small canine Babesia identified in California. Vet Parasitol. 138, 103-111.
  • Konishi K, Sakata Y, Miyazaki N, Jia H, Goo YK, Xuan X, Inokuma H, (2008). Epidemiological survey of Babesia gibsoni infection in dogs in Japan by enzyme-linked immunosorbent assay using B.gibsoni thrombospondin-related adhesive protein antigen. Vet Parasitol. 155, 204-208.
  • Kuttler KL, (1988). World-wide impact of babesiosis. Ristic, M. eds. Babesiosis of Domestic Animals and Man. CRC Press. Florida. p.163-189.
  • Levy MG, Breitschwerdt EB, Moncol DJ, (1987). Antibody activity to Babesia canis in dogs in North Carolina. Am J Vet Res. 48, 339-341.
  • Lobetti RG, (1998). Canine babesiosis. Comp Cont Ed Pract Vet. 20, 418-431.
  • Matjila PT, Leisewitz AL, Ooshuizen MC, Jongejan F, Penzhorn B, (2008). Detection of a Theileria species in dogs in South Africa. Vet Parasitol. 157, 34-40.
  • Matsuu A, Ono S, Ikadai H, Uchide T, Imamura S, Onuma M, OkanaoS, Higuchi S, (2005). Development of a SYBR green real-timepolymerase chain reaction assay for quantitative detection of Babesia gibsoni (Asian genotype) DNA. J Vet Diagn Invest. 17, 569–573.
  • Melhorn H, (2001). Encylopedic reference of parasitology. Diseases, Treatment, Therapy.Erişim adresi: http:parasitology.informatik.uniwuerzberg.de/login/frame.php Erişim tarihi: 05.04.2006.
  • Merdivenci A, (1970). Türkiye parazitleri ve parazitolojik yayınları. Kutulmuş Matbaası, İstanbul.322.
  • Özcan CH, (1961). Ankara ve civarında evcil hayvanlarda görülen piroplasmose vakaları ve tedavileri üzerinde araştırmalar. A.Ü. Vet. Fak. Yay., 143, Çalışmalar: 83, Ankara.
  • Quinn PJ, Donnely WJC, Carter ME, Markey BKJ, Torgenson PR, Breathnach RMS, eds., (1997). Microbial and parasitic diseases of the dog and cat. First edition. London: Saunders Press, p.211.
  • Schetters TP, Kleuskens J, Carcy B, Gorenflot A, Vermeulen A, (2007). Vaccination against large Babesia species from dogs. Prassitologia. 49, 13-17.
  • Soulsby EJL, (1982). Helminths, arthropods and protozoa of domesticated animals. 7 th ed London. Bailliere Tindall,
  • Solano-Gallego L, Trotta M, Carli E, Carcy B, Caldin M, Furlanello T, (2008). Babesia canis canis and Babesia canis vogeli clinicopathological findings and DNA detection by means of PCR-RFLP in blood from Italian dogs suspected of tick-borne disease. Vet Parasitol.157, 211-221.
  • Uilenberg G, Franseen FFJ, Perie NM, Perie M, Spanjer AAM, (1989). Three groups of Babesia canis distinguished and a proposal for nomenclature. Vet Q. 11, 33-40.
  • Ulutaş B, Paşa S, Karagenç T, Bayramlı G, (2003). Atipik babesiosisli iki köpekte klinik görünüm. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi. 5. Ulusal Veteriner İç Hastalıkları Kongresi. Poster Bildirisi. 165.
  • Ulutaş B, Bayramlı G, Ulutaş PA, Karagenç T, (2005). Serum concentration of some acute phase proteins in naturally occuring canine Babesiosis: A preliminary study. Vet Clin Pathol. 34, 144-147.
  • Zahler ME, Scheın H, Rınder R, Gothe, (1998). Characteristic genotypes discriminate between Babesia canis isolates of differing vector specificity and pathogenicity to dogs. Parasitol Res. 84, 544-548.
  • Zahler M, Rinder H, Schein E, Gothe R, (2000). Detection of a new pathogenic Babesia microti-like species in dogs. Vet Parasitol. 89, 241-248.

Köpeklerde Babesiosis

Yıl 2011, Cilt: 22 Sayı: 2, 74 - 78, 29.12.2011

Öz

Köpeklerde babesiosis, kenelerle bulaşan Babesia canis ve Babesia gibsoni’nin sebep olduğu protozoer bir hastalıktır. Parazitler eritrositleri enfekte eder ve tipik olarak hemolitik anemi yaparlar. B.canis büyük babesialar grubundan olup B.canis canis, B.canis rossi ve B.canis vogeli olmak üzere üç alt türü vardır. Morfolojik olarak aynı görünmelerine rağmen, vektörleri, (sırasıyla Dermacentor reticulatus, Haemaphysalis laechi ve Rhipicephalus sanguineus), coğrafik yayılışları, antijenik yapıları ve köpeklerde patojeniteleri farklıdır. B.gibsoni enfeksiyonları genel olarak B.canis’ den daha şiddetli klinik semptomlara ve organ yetmezliklerine sebep olurlar. Son yıllarda yapılan moleküler çalışmalar ile köpeklerin büyük ve küçük Babesia etkenlerinin kabul edildiğinden daha fazla olduğu bulunmuştur.

Kaynakça

  • Aboge GO, Jia H, Terkawi MA, Goo Y, Kuriki K, Nishikawa Y, Igarashi I, Suzuki H, Xuan X, (2007). A novel 57-kDa merozoite protein of Babesia gibsoni is a prospective antigen for diagnosis and serosurvey of canine babesiosis by enzyme-linked immunosorbent assay. Vet Parasitol. 149, 85-94.
  • Anderson JF, Magnarelli LA, Sulzer AJ, (1980). Canine babesiosis: ındirect fluorescent antibody test for a North American isolate of Babesia gibsoni. Am J Vet Res. 41, 2102-2105.
  • Aysul N, (2006). İstanbul ili köpeklerinde bulunan babesia türlerinin teşhisinde mikroskobik ve PCR-RLB bulgularının karşılaştırılması. Doktora Tezi,.İ.Ü. Sağlık Bilimleri Enstitüsü, İstanbul.
  • Aysul N, Ural K, Ulutaş B, Eren H, Karagenç T, (2009). Aydın ilinde bir köpekte Babesia gibsoni olgusu. 16. Ulusal Parazitoloji Kongresi Poster bildirisi. Adana.
  • Birkenheuer AJ, Levy MG, Breitschwerdt EB, (2003). Development and evaluation of a seminested PCR for detection and differentiation of Babesia gibsoni (Asian genotype) and B. canis DNA in canine blood samples. J Clin Microbiol. 41, 72-77.
  • Birkenheuer AJ, Neel J, Ruslander D, Levy MG, Breitschwerdt EB, (2004). Detection and molecular characterization of a novel large Babesia species in a dog. Vet Parasitol. 124, 151-160.
  • Birkenheuer AJ, Correa MT, Levy MG, Breitschwerdt EB, (2005). Geographic distribution of babesiosis among dogs in the United States and association with dog bites: 150 cases (2000-2003). J Am Vet Med Assoc. 227, 942-947.
  • Blood DC, Otto MR, Gay CC, Radostits OM, (1994). A Textbook of the diseases of cattle, sheep, pigs, goats and horses. 7nd ed. London: Veterinary Medicine Bailliere Tindall.
  • Böhm M, Leisewitz AL,Thompson PN, Schoeman JP, (2006). Capillary and venous Babesia canis rossi parasitaemias and their association with outcome of infection and circulatory compromise. Vet Parasitol. 141, 18-29.
  • Camacho AT, Guitian FJ, Pallas E, Gestal JJ, Olmeda AS, Goethert HK, Telford III SR, Spielman A, (2004). Azotaemia and mortality among Babesia-microti-like infected dogs. J Vet Int Med. 18, 141-146.
  • Carret C, Walas F, Carcy B, Grande N, Precigout E, Moubri K, Schetters PT, Gorenflot A, (1999). Babesia canis canis, Babesia canis vogeli, Babesia canis rossi: differentiation of the three subspecies by a restriction fragment length polymorphism analysis on amplified small subunit ribosomal RNA genes. J Eukaryot Microbiol. 46, 298-303.
  • Conrad P, Thomford J, Yamane I, Whiting J, Bomsa L, Uno T, Holshuh HJ, Shelly S, (1991). Hemolytic anemia caused by Babesia gibsoni infection in dogs. J Am Vet Med Assoc. 199, 601-605.
  • Criado-Fornelio A, Martinez-Marcos A, Buling-Sarana A, Barba-Carretero JC, (2003). Molecular studies on Babesia, Theileria and Hepatozoon in southern Europe. Part I. Epizootiological aspects. Vet Parasitol. 113, 189-201.
  • Fukumoto S, Xuan X, Shigeno S, Kimbita E, Igarashi I, Nagasawa H, Fujisaki K, Mikami T, (2001) . Development of a polymerase chain reaction methods for diagnosing Babesia gibsoni infection in dogs. J Vet Med Sci. 63, 977-981.
  • Georges K, Ezeokoli CD, Newaj-Fyzul A, Campbell M, Mootoo N, Mutani A, Sparagano OAE, (2008). The application of PCR and reverse line blot hybridization to detect arthropod-borne haemopathogens of dogs and cats in Trinidad. Ann N Y Acad Sci. 1149, 196-199.
  • Goo Y, Jia H, Aboge GO, Terkawi MA, Kuriki K, Nakamura C, Kumagai A, Zhou J, Lee EG, Nishikawa Y, (2008). Babesia gibsoni: Serodiagnosis of infection in dogs by an enzyme-linked immunosorbent assay with recombinant BgTRAP. Exp Parasitol. 118, 555-560.
  • Gören S, Yetkin R, (1935). Tektırnaklıda, sığırda, koyunda, keçide ve köpekte piroplasmoz. M.M.B. Bakt. Evi Yayını.Ulus Basımevi,.Ankara. 104 s.
  • Gülanber A, Gorenflot A, Schetters TP, Carcy B, (2006). First molecular diagnosis of Babesia vogeli in domestic dogs from Turkey. Vet Parasitol. 139, 224-230.
  • Irwin PJ, Hutchinson GW, (1991). Clinical and pathological findings of Babesia infection in dogs. Aust Vet J: 68, 204-209.
  • Irwin PJ, (2009). Canine babesiosis: from molecular taxonomy to control. Parasites and Vectors. Erişim adresi: (http://www.parasitesandvectors.com/content/2/S1/S4) Erişim tarihi: 27. 03. 2009.
  • Jefferies R, Ryan U, Irwin P, (2007). PCR-RFLP for the detection and differentiation of the canine piroplasm species and its use with filter paper-based technologies.Vet Parasitol. 144, 20-27.
  • Kırlı G, (2006). Ege Bölgesi’nde köpek Babesiosis’inin yaygınlığı. Yüksek Lisans Tezi ADÜ. Sağlık Bilimleri Enstitüsü, Aydın.
  • Kjemtrup AM, Wainwright K, Miller M, Penzhorn BL, Carreno RA, (2006). Babesia conradae, sp. nov., a small canine Babesia identified in California. Vet Parasitol. 138, 103-111.
  • Konishi K, Sakata Y, Miyazaki N, Jia H, Goo YK, Xuan X, Inokuma H, (2008). Epidemiological survey of Babesia gibsoni infection in dogs in Japan by enzyme-linked immunosorbent assay using B.gibsoni thrombospondin-related adhesive protein antigen. Vet Parasitol. 155, 204-208.
  • Kuttler KL, (1988). World-wide impact of babesiosis. Ristic, M. eds. Babesiosis of Domestic Animals and Man. CRC Press. Florida. p.163-189.
  • Levy MG, Breitschwerdt EB, Moncol DJ, (1987). Antibody activity to Babesia canis in dogs in North Carolina. Am J Vet Res. 48, 339-341.
  • Lobetti RG, (1998). Canine babesiosis. Comp Cont Ed Pract Vet. 20, 418-431.
  • Matjila PT, Leisewitz AL, Ooshuizen MC, Jongejan F, Penzhorn B, (2008). Detection of a Theileria species in dogs in South Africa. Vet Parasitol. 157, 34-40.
  • Matsuu A, Ono S, Ikadai H, Uchide T, Imamura S, Onuma M, OkanaoS, Higuchi S, (2005). Development of a SYBR green real-timepolymerase chain reaction assay for quantitative detection of Babesia gibsoni (Asian genotype) DNA. J Vet Diagn Invest. 17, 569–573.
  • Melhorn H, (2001). Encylopedic reference of parasitology. Diseases, Treatment, Therapy.Erişim adresi: http:parasitology.informatik.uniwuerzberg.de/login/frame.php Erişim tarihi: 05.04.2006.
  • Merdivenci A, (1970). Türkiye parazitleri ve parazitolojik yayınları. Kutulmuş Matbaası, İstanbul.322.
  • Özcan CH, (1961). Ankara ve civarında evcil hayvanlarda görülen piroplasmose vakaları ve tedavileri üzerinde araştırmalar. A.Ü. Vet. Fak. Yay., 143, Çalışmalar: 83, Ankara.
  • Quinn PJ, Donnely WJC, Carter ME, Markey BKJ, Torgenson PR, Breathnach RMS, eds., (1997). Microbial and parasitic diseases of the dog and cat. First edition. London: Saunders Press, p.211.
  • Schetters TP, Kleuskens J, Carcy B, Gorenflot A, Vermeulen A, (2007). Vaccination against large Babesia species from dogs. Prassitologia. 49, 13-17.
  • Soulsby EJL, (1982). Helminths, arthropods and protozoa of domesticated animals. 7 th ed London. Bailliere Tindall,
  • Solano-Gallego L, Trotta M, Carli E, Carcy B, Caldin M, Furlanello T, (2008). Babesia canis canis and Babesia canis vogeli clinicopathological findings and DNA detection by means of PCR-RFLP in blood from Italian dogs suspected of tick-borne disease. Vet Parasitol.157, 211-221.
  • Uilenberg G, Franseen FFJ, Perie NM, Perie M, Spanjer AAM, (1989). Three groups of Babesia canis distinguished and a proposal for nomenclature. Vet Q. 11, 33-40.
  • Ulutaş B, Paşa S, Karagenç T, Bayramlı G, (2003). Atipik babesiosisli iki köpekte klinik görünüm. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi. 5. Ulusal Veteriner İç Hastalıkları Kongresi. Poster Bildirisi. 165.
  • Ulutaş B, Bayramlı G, Ulutaş PA, Karagenç T, (2005). Serum concentration of some acute phase proteins in naturally occuring canine Babesiosis: A preliminary study. Vet Clin Pathol. 34, 144-147.
  • Zahler ME, Scheın H, Rınder R, Gothe, (1998). Characteristic genotypes discriminate between Babesia canis isolates of differing vector specificity and pathogenicity to dogs. Parasitol Res. 84, 544-548.
  • Zahler M, Rinder H, Schein E, Gothe R, (2000). Detection of a new pathogenic Babesia microti-like species in dogs. Vet Parasitol. 89, 241-248.
Toplam 41 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Veteriner Cerrahi
Bölüm Derleme
Yazarlar

Nuran Aysul Bu kişi benim

Yayımlanma Tarihi 29 Aralık 2011
Gönderilme Tarihi 1 Aralık 2011
Yayımlandığı Sayı Yıl 2011 Cilt: 22 Sayı: 2

Kaynak Göster

APA Aysul, N. (2011). Köpeklerde Babesiosis. Etlik Veteriner Mikrobiyoloji Dergisi, 22(2), 74-78.


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