The Therapeutic Effect of p-Coumaric Acid on Lung Toxicity Induced by Methotrexate in Rats

Selim Demir; Nihal Türkmen Alemdar; Elif Ayazoglu Demir; Ahmet Mentese; Yüksel Aliyazıcıoğlu

doi:10.59518/farabimedj.1484155

TR EN

Sıçanlarda Metotreksatın Neden Olduğu Akciğer Toksisitesi Üzerine p-Kumarik Asidin Terapötik Etkisi

Öz

Bir kemoterapötik ajan olarak metotreksatın (MTX) kullanımı, akciğer toksisitesi de dahil olmak üzere bir takım yan etkiler nedeniyle sınırlıdır. Oksidatif stres (OS) ve inflamasyon, MTX ile ilişkili akciğer toksisitesinin olası mekanizmalarıdır. p-Kumarik asit (PCA), özellikle antioksidan ve anti-inflamatuar olmak üzere insan sağlığı üzerinde çeşitli yararlı etkileri olan bir fenolik asittir. Bu çalışmada PCA'nın MTX kaynaklı akciğer toksisitesini azaltmadaki potansiyel etkileri araştırıldı. Ratlara 1. günde MTX (20 mg/kg) enjeksiyonunu takiben 3 gün boyunca iki farklı dozda PCA (2 ve 4 mg/kg) intraperitoneal olarak uygulandıktan sonra 5.günde akciğer dokuları toplanarak OS, inflamasyon ve apoptoz düzeyleri değerlendirildi. PCA uygulamaları, endojen antioksidan sistemin kapasitesini artırarak akciğer dokusunda MTX'in neden olduğu OS, inflamasyon ve apoptozu büyük ölçüde ortadan kaldırdı. PCA'nın MTX kaynaklı akciğer toksisitesine karşı terapötik etkisinin daha sistematik çalışmalarla yeniden değerlendirilmesi gerekmektedir.

Anahtar Kelimeler

Akciğer toksisitesi , Apoptoz , İnflamasyon , Metotreksat , Oksidatif stres , p-Kumarik

The Therapeutic Effect of p-Coumaric Acid on Lung Toxicity Induced by Methotrexate in Rats

Abstract

The use of methotrexate (MTX), a chemotherapy agent, is limited by a number of side effects, including pulmonary toxicity. Oxidative stress (OS) and inflammation are possible mechanisms of MTX-associated pulmonary toxicity. p-Coumaric acid (PCA) is a phenolic acid that has been demonstrated to exert a number of beneficial effects on human health, particularly in relation to antioxidant and anti-inflammatory activity. The potential effects of PCA in reducing MTX-induced pulmonary toxicity were investigated in the current study. After MTX (20 mg/kg) was administered to the rats on day 1, two different doses of PCA (2 and 4 mg/kg) were administered intraperitoneally for 3 days and the levels of OS, inflammation and apoptosis were assessed in the lung tissues collected on day 5. PCA applications largely eliminated MTX-induced OS, inflammation and apoptosis in lung tissue via enhancing the capacity of endogenous antioxidant system. The therapeutic effect of PCA against MTX-induced pulmonary toxicity should be re-evaluated in more systematic studies.

Keywords

Apoptosis , Inflammation , Methotrexate , Oxidative stress , p-Coumaric acid , Pulmonary toxicity

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Details

Primary Language

English

Subjects

Toxicology , Metabolic Medicine

Journal Section

Research Article

Authors

Selim Demir ^*
0000-0002-1863-6280
Türkiye

Nihal Türkmen Alemdar
0000-0002-8913-8692
Türkiye

Elif Ayazoglu Demir
0000-0001-7188-2176
Türkiye

Ahmet Mentese
0000-0003-2036-5317
Türkiye

Yüksel Aliyazıcıoğlu
0000-0001-9474-4307
Türkiye

Publication Date

June 30, 2024

Submission Date

May 14, 2024

Acceptance Date

June 15, 2024

Published in Issue

Year 2024 Volume: 3 Number: 2

DOI

https://doi.org/10.59518/farabimedj.1484155

IZ

https://izlik.org/JA42UT93MD

APA

Demir, S., Türkmen Alemdar, N., Ayazoglu Demir, E., Mentese, A., & Aliyazıcıoğlu, Y. (2024). The Therapeutic Effect of p-Coumaric Acid on Lung Toxicity Induced by Methotrexate in Rats. Farabi Tıp Dergisi, 3(2), 57-62. https://doi.org/10.59518/farabimedj.1484155

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