The Genetics of Parkinson’s Disease

Zeliha Yücel; Levent Şimşek; Emine Berrin Yüksel

doi:10.54005/geneltip.1337447

EN TR

The Genetics of Parkinson’s Disease

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative diseases worldwide. Approximately 15% of PD patients have a family history of the disease in one or more first-degree relatives, and 5-10% of PD cases exhibit a classical Mendelian inheritance pattern. In 1997, the heritable transmission of PD was first documented. Recent studies have found 90 independent genome-wide signals at 78 loci that may be associated with PD. The identification of genes linked to PD and their functions has uncovered novel biological pathways and treatment options that play a role in the development of PD. In this article, it is aimed to review up-to-date information on the genetics of PD.

Keywords

Parkinson’s Disease, Inheritance, Autosomal Dominant, Autosomal Recessive

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Primary Language

English

Subjects

Medical Genetics (Excl. Cancer Genetics), Clinical Sciences (Other)

Journal Section

Review

Authors

Zeliha Yücel ^*
0000-0002-2303-9704
Türkiye

Levent Şimşek
0000-0001-7729-3970
Türkiye

Emine Berrin Yüksel
0000-0001-7107-1939
Türkiye

Early Pub Date

February 26, 2024

Publication Date

February 29, 2024

Submission Date

August 3, 2023

Acceptance Date

December 18, 2023

Published in Issue

Year 2024 Volume: 34 Number: 1

DOI

https://doi.org/10.54005/geneltip.1337447

IZ

https://izlik.org/JA85UA54YK

APA

Yücel, Z., Şimşek, L., & Yüksel, E. B. (2024). The Genetics of Parkinson’s Disease. Genel Tıp Dergisi, 34(1), 136-143. https://doi.org/10.54005/geneltip.1337447

AMA

1.Yücel Z, Şimşek L, Yüksel EB. The Genetics of Parkinson’s Disease. Genel Tıp Derg. 2024;34(1):136-143. doi:10.54005/geneltip.1337447

Chicago

Yücel, Zeliha, Levent Şimşek, and Emine Berrin Yüksel. 2024. “The Genetics of Parkinson’s Disease”. Genel Tıp Dergisi 34 (1): 136-43. https://doi.org/10.54005/geneltip.1337447.

EndNote

Yücel Z, Şimşek L, Yüksel EB (February 1, 2024) The Genetics of Parkinson’s Disease. Genel Tıp Dergisi 34 1 136–143.

IEEE

[1]Z. Yücel, L. Şimşek, and E. B. Yüksel, “The Genetics of Parkinson’s Disease”, Genel Tıp Derg, vol. 34, no. 1, pp. 136–143, Feb. 2024, doi: 10.54005/geneltip.1337447.

ISNAD

Yücel, Zeliha - Şimşek, Levent - Yüksel, Emine Berrin. “The Genetics of Parkinson’s Disease”. Genel Tıp Dergisi 34/1 (February 1, 2024): 136-143. https://doi.org/10.54005/geneltip.1337447.

JAMA

1.Yücel Z, Şimşek L, Yüksel EB. The Genetics of Parkinson’s Disease. Genel Tıp Derg. 2024;34:136–143.

MLA

Yücel, Zeliha, et al. “The Genetics of Parkinson’s Disease”. Genel Tıp Dergisi, vol. 34, no. 1, Feb. 2024, pp. 136-43, doi:10.54005/geneltip.1337447.

Vancouver

1.Zeliha Yücel, Levent Şimşek, Emine Berrin Yüksel. The Genetics of Parkinson’s Disease. Genel Tıp Derg. 2024 Feb. 1;34(1):136-43. doi:10.54005/geneltip.1337447

Cited By

Familial young-onset Parkinson’s disease associated with SNCA gene duplication: a case series of three sisters from Turkey

Neurocase

https://doi.org/10.1080/13554794.2026.2620678

The Journal of General Medicine is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY NC).

The Genetics of Parkinson’s Disease

Abstract

Keywords

Parkinson Hastalığı Genetiği

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Familial young-onset Parkinson’s disease associated with SNCA gene duplication: a case series of three sisters from Turkey