Abstract
Objective: Beta thalassemia β-Thal is a chronic anemia in which while oxidants stress increases, antioxidant capacity decreases. Paroxanase is an enzyme having antioxidant properties. In this study we searched markers effecting paroxanase activity in β-Thal patients.Materials and Methods: In this study we measured serum paroxanase activity, complete blood count, fasting glucose, BUN, creatinin, sodium, potassium, chloride, calcium, AST, ALT, LDH, albumin, globulin, uric acid, indirect bilirubin, direct bilirubin, TSH, parathyroid hormone, ferritin, and vitamin B12 in 46 β-Thal patients.Results: We found that there is a significant correlation between serum paroxanase activity, serum chloride level, and serum TSH r=0.319, p
Keywords
References
- Ginzburg Y, Rivella S. β-thalassemia: a model for elucida- ting the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood 2011;118:4321-30.
- Furlong CE, Marsillach J, Jarvik GP, et al. Paraoxonases-1, -2 and -3: What are their functions? Chem Biol Interact 2016; 259:51-62.
- Muchová J, Andrezálová L, Oravec S, et al. High density li- poprotein subfractions and paraoxonase 1 in children. Acta Biochim Pol 2016;63:555-63.
- Bayrak A, Bayrak T, Bodur E, et al. The effect of HDL- bound and free PON1 on copper-induced LDL oxidation. Chem Biol Interact 2016;257:141-6.
- Yunoki K, Naruko T, Inaba M, et al.Gender-specific corre- lation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease. Atherosclerosis 2013;231:308-14.
- Gateva A, Assyov Y, Tsakova A, et al. Serum Paraoxonase-1 Levels are Significantly Decreased in the Presence of Insulin Resistance. Exp Clin Endocrinol Diabetes 2016;124:444-7.
- Rodríguez-Carrio J, Alperi-López M, López-Mejías R, et al. Antibodies to paraoxonase 1 are associated with oxidant status and endothelial activation in rheumatoid arthritis. Clin Sci (Lond) 2016;130:1889-99.
- Zohaib M, Ansari SH, Hashim Z, et al.Serum Paraoxonase Activity and Malondialdehyde Serum Concentrations Re- main Unaffected in Response to Hydroxyurea Therapy in β-Thalassemia Patients. J Clin Pharmacol 2016;56:869-74.
- Devarajan A, Shih D, Reddy ST. Inflammation, infection, cancer and all that the role of paraoxonases. Adv Exp Med Biol 2014;824:33-41.
- Boudrahem-Addour N, Izem-Meziane M, Bouguerra K. Oxidative status and plasma lipid profile in β-thalassemia patients. Hemoglobin 2015;39:36-41.
- Cakmak A, Soker M, Koc A, et al. Paraoxonase and aryles- terase activity with oxidative status in children with thalas- semia major. J Pediatr Hematol Oncol 2009;31:583-7.
- Cebeci E, Oner FA, Usta M, et al. Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in pa- tients with subclinic hypothyroidism. Acta Biomed 2011; 82:214-22.
- Ates I, Altay M, Yilmaz FM, et al. The impact of levothy- roxine sodium treatment on oxidative stress in Hashimoto's thyroiditis. Eur J Endocrinol 2016;174:727-34.
- Yavuz DG, Yüksel M, Deyneli O, et al. Association of serum paraoxonase activity with insulin sensitivity and oxidative stress in hyperthyroid and TSH-suppressed nodular goitre patients. Clin Endocrinol (Oxf) 2004;61:515-21.
- Raiszadeh F, Solati M, Etemadi A, et al. Serum paraoxonase activity before and after treatment of thyrotoxicosis. Clin Endocrinol (Oxf) 2004;60:75-80.
- Gülcü F, Gürsu F. The Standardization of Paraoxonase and Arylesterase Activity Measurements Turk J Biochem 2003; 28: 45-9.
Beta Talasemi Hastalarında Serum Paraoksonaz Aktivitesi İle Biyokimyasal Parametreler Arasındaki İlişki
Abstract
Amaç: Beta talasemi β-Thal oksidan stessin arttığı, antioksidan kapasitenin azaldığı kronik hemolitik bir anemidir. Paraoksonaz antioksidan özelliği olan bir enzimdir. Bu çalışmamızda β-Thal hastalarında paraoksonaz aktivitesini etkileyen belirteçleri araştırdık.Gereç ve Yöntem: 46 β-Thal hastasında yapılan çalışmamızda serum paraoksonaz aktivitesi, tam kan sayımı ve açlık glukoz, BUN, kreatinin, sodyum, potasyum, klorür, kalsiyum, AST, ALT, LDH, albumin, globulin, ürik asit, indirekt bilurubin, direkt bilurubin, TSH, parathormon, ferritin, B12 düzeyleri ölçüldü.Bulgular: Serum paraoksonaz aktivitesi ile serum klorür r=0.319, p
Keywords
References
- Ginzburg Y, Rivella S. β-thalassemia: a model for elucida- ting the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood 2011;118:4321-30.
- Furlong CE, Marsillach J, Jarvik GP, et al. Paraoxonases-1, -2 and -3: What are their functions? Chem Biol Interact 2016; 259:51-62.
- Muchová J, Andrezálová L, Oravec S, et al. High density li- poprotein subfractions and paraoxonase 1 in children. Acta Biochim Pol 2016;63:555-63.
- Bayrak A, Bayrak T, Bodur E, et al. The effect of HDL- bound and free PON1 on copper-induced LDL oxidation. Chem Biol Interact 2016;257:141-6.
- Yunoki K, Naruko T, Inaba M, et al.Gender-specific corre- lation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease. Atherosclerosis 2013;231:308-14.
- Gateva A, Assyov Y, Tsakova A, et al. Serum Paraoxonase-1 Levels are Significantly Decreased in the Presence of Insulin Resistance. Exp Clin Endocrinol Diabetes 2016;124:444-7.
- Rodríguez-Carrio J, Alperi-López M, López-Mejías R, et al. Antibodies to paraoxonase 1 are associated with oxidant status and endothelial activation in rheumatoid arthritis. Clin Sci (Lond) 2016;130:1889-99.
- Zohaib M, Ansari SH, Hashim Z, et al.Serum Paraoxonase Activity and Malondialdehyde Serum Concentrations Re- main Unaffected in Response to Hydroxyurea Therapy in β-Thalassemia Patients. J Clin Pharmacol 2016;56:869-74.
- Devarajan A, Shih D, Reddy ST. Inflammation, infection, cancer and all that the role of paraoxonases. Adv Exp Med Biol 2014;824:33-41.
- Boudrahem-Addour N, Izem-Meziane M, Bouguerra K. Oxidative status and plasma lipid profile in β-thalassemia patients. Hemoglobin 2015;39:36-41.
- Cakmak A, Soker M, Koc A, et al. Paraoxonase and aryles- terase activity with oxidative status in children with thalas- semia major. J Pediatr Hematol Oncol 2009;31:583-7.
- Cebeci E, Oner FA, Usta M, et al. Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in pa- tients with subclinic hypothyroidism. Acta Biomed 2011; 82:214-22.
- Ates I, Altay M, Yilmaz FM, et al. The impact of levothy- roxine sodium treatment on oxidative stress in Hashimoto's thyroiditis. Eur J Endocrinol 2016;174:727-34.
- Yavuz DG, Yüksel M, Deyneli O, et al. Association of serum paraoxonase activity with insulin sensitivity and oxidative stress in hyperthyroid and TSH-suppressed nodular goitre patients. Clin Endocrinol (Oxf) 2004;61:515-21.
- Raiszadeh F, Solati M, Etemadi A, et al. Serum paraoxonase activity before and after treatment of thyrotoxicosis. Clin Endocrinol (Oxf) 2004;60:75-80.
- Gülcü F, Gürsu F. The Standardization of Paraoxonase and Arylesterase Activity Measurements Turk J Biochem 2003; 28: 45-9.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Original Article |
| Authors | |
| Publication Date | March 1, 2017 |
| Published in Issue | Year 2017 Volume: 27 Issue: 1 |
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