Does Serum R-Spondin-1 Play a Role in PCOS Pathophysiology?

Year 2022, Volume: 32 Issue: 5, 490 - 493, 29.10.2022

Osman Başpınar , Yasin Şimşek , Derya Koçer , Oğuzhan Sıtkı Dizdar , Hatice Kayış Topaloğlu

https://doi.org/10.54005/geneltip.1111079

Abstract

Objective: Many new inflammatory and metabolic markers are considered to be involved in etiology of Polycystic ovary syndrome (PCOS). R-spondin-1 (Rspo1) is a member of the roof plate-specific spondin protein family. Rspo1 levels have been associated with obesity and insulin resistance. We aimed to investigate whether Rspo1 has a role in the pathophysiology of PCOS.

Materials and Methods: This cross-sectional study was planned with newly diagnosed and untreated PCOS cases and a control group without PCOS. Patients with PCOS and healty participants were compared for Rspo1 levels. In addition, the PCOS group was also grouped according to body mass index (BMI) and Ferriman Gallwey scores (FGS) and compared in terms of Rsop1 levels.

Results: A total of 47 patients in the PCOS group and 36 participants in the control group, as total 83 participants were included in the study. PCOS and control groups had similar age and BMI. As compared to the control group, PCOS patients had significantly higher FGS, homeostasis model assessment of insulin resistance scores, Rspo1, and total testosterone levels (p<0.001, p=0.01, p=0.02, p=0.001 respectively). When subclassing PCOS patients according to BMI and FGS values, there was no statistically significant difference between Rspo1 levels in terms of both BMI and FGS values. Moreover, Rspo1 showed a significant positive correlation with total testosterone and dehydroepiandrosterone sulfate levels (p=0.03, r=0.23; p=0.08, r=0.30, respectively).

Conclusion: Rspo-1 may be associated with PCOS pathophysiology via total testosterone and dehydroepiandrosterone sulphate. Further molecular and genetic studies are needed to support this hypothesis.

Keywords

R-spondin-1, Polycystic ovary syndrome, Ferriman Gallwey scores

Supporting Institution

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Project Number

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Thanks

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PCOS Patofizyolojisinde Serum R-Spondin-1'in Bir Rolü Var mıdır?

Abstract

Amaç: Pek çok yeni inflamatuar ve metabolik belirtecin Polikistik Over Sendromu (PCOS) etiyolojisinde rol oynadığı düşünülmektedir. R-spondin-1 (Rspo1), tepe tabakaya özgü spondin protein ailesinin bir üyesidir. Rspo1 seviyeleri obezite ve insülin direnci ile ilişkilendirilmiştir. Rspo1'in PCOS patofizyolojisinde rolü olup olmadığını araştırmayı amaçladık.

Gereç ve Yöntem: Bu kesitsel çalışma, yeni tanı konmuş ve tedavi edilmemiş PCOS olguları ve PCOS'u olmayan bir kontrol grubu ile planlandı. PCOS'lu hastalar ve sağlıklı katılımcılar, Rspo1 seviyeleri için karşılaştırıldı. Ayrıca PCOS grubu vücut kitle indeksi (VKİ) ve Ferriman Gallwey skorlarına (FGS) göre de gruplandırılarak Rsop1 düzeyleri açısından karşılaştırıldı.

Bulgular: PCOS grubunda 47, kontrol grubunda 36 olmak üzere toplam 83 katılımcı çalışmaya dahil edildi. PCOS ve kontrol grupları benzer yaş ve VKİ'ye sahipti. Kontrol grubu ile karşılaştırıldığında, PCOS hastalarının FGS, insülin direnci skorlarının homeostaz modeli değerlendirmesi, Rspo1 ve toplam testosteron düzeyleri anlamlı olarak daha yüksekti (sırasıyla p<0,001, p=0.01, p=0.02, p=0.001). PCOS hastaları BMI ve FGS değerlerine göre alt sınıflara ayrıldığında, hem BMI hem de FGS değerleri açısından Rspo1 seviyeleri arasında istatistiksel olarak anlamlı bir fark yoktu. Ayrıca, Rspo1, toplam testosteron ve dehidroepiandrosteron sülfat seviyeleri ile anlamlı bir pozitif korelasyon gösterdi (sırasıyla p=0.03, r=0.23; p=0.08, r=0.30).

Sonuç: Rspo-1, toplam testosteron ve dehidroepiandrosteron sülfat yoluyla PCOS patofizyolojisi ile ilişkilendirilebilir. Bu hipotezi desteklemek için daha fazla moleküler ve genetik çalışmalara ihtiyaç vardır.

Keywords

R-spondin-1, Polikistik over sendromu, Ferriman Gallwey skorları

Project Number

none

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