Long-term Survival Outcomes of Early-stage Grade 1 and 2 EndometrioidType Endometrial Cancer Patients

Year 2023, Volume: 33 Issue: 2, 232 - 238, 30.04.2023

Fazıl Avcı , Orhan Önder Eren , Ahmet Bilgi , Hamit Başaran , Murat Celik , Melek Caglayan , Cetin Celik

https://doi.org/10.54005/geneltip.1265954

Abstract

Aims: Early-stage endometrioid-type endometrial cancer (EC) has a favorable prognosis. The recurrence is still the biggest issue. There are differences in the literature in terms of treatment modalities in early-stage. We investigated long-term survival outcomes of early-stage grade 1 and 2 endometrioid-type EC patients.
Methods: Out of 327 cases, 294 cases in stage 1 and 33 cases in stage 2 were evaluated. Age, stage, tumor size, histologic grade, degree of myometrial invasion, presence of lymphovascular invasion (LVSI), peritoneal cytology positive, presence of recurrence, overall survival (OS), and disease-free survival (DFS) between two groups were evaluated statistically.
Results: The mean age of 327 patients was 64.0±10.0 years. Out of 327, 65.7% were ≥60 years, 90% were stage 1, 74.6% were grade 1, 1.8% had positive peritoneal cytology, 8.3% had LVSI and 86% had ≤50% myometrial invasion. Recurrence was detected in 6.4% of patients. 40.7% of patients received adjuvant radiotherapy. Only the adjuvant radiotherapy was found a significant association between two groups. Only presence of recurrence in terms of OS and DFS durations was a significant parameter in the regression analysis.
Conclusions: Development of recurrence in early-stage endometrioid-type EC is the main prognostic predictor for survival. The early diagnosis and treatment of recurrence have a positive impact on the prognosis.

Keywords

endometrial cancer, endometrioid type, recurrence, survival

Supporting Institution

None

Project Number

None

Thanks

None

Erken Evre Grade 1 ve 2 Endometrioid Tip Endometrium Kanseri Tanılı Olgularda Uzun Dönem Sonuçları

Abstract

Özet
Amaç: Erken evre endometrioid tipi endometrial kanser (EC) iyi bir prognoza sahiptir. rekürrens hala en büyük sorundur. Literatürde erken evrede tedavi yöntemleri açısından farklılıklar vardır. Erken evre grade 1 ve 2 endometrioid tip endometriyum kanseri tanılı olgularda uzun dönem sonuçlarını retrospektif olarak araştırmaktır.
Method: toplam 327 olgudan evre 1’de 294 olgu ve evre 2’de 33 olgu değerlendirildi. İki grup arasında yaş, evre, tümör çapı, grade, myometrial invazyon derecesi, lenfovasküler invazyon (LVSI) varlığı, periton sitolojisi pozitifliği, rekürrens varlığı, genel sağkalım (OS) ve hastalıksız sağkalım (DFS) süreleri istatistiki olarak değerlendirildi.
Bulgular: Toplam 327 olgunun yaş ortalaması 64,0±10,0 yıl olrak hesaplandı. 327 olgudan 60 yaş ve üstü olgular %65,7, olguların %90’ı evre 1 ve %74,6’sı grade 1, periton sitolojisi %1,8 oranında pozitif, ve LVSI varlığı %8,3’ünde pozitif, ve %50’den az myometrial invazyon olguların %86,5’inde saptandı. Rekürrens, olguların %6,4’ünde saptandı. Olgulara adjuvan radyoterapi %40,7 oranında uygulandı. Olgular evre 1 ve evre 2 olarak karşılaştırıldığında sadece adjuvan radyoterapi tedavisi açısından anlamlı fark saptandı. OS ve DFS süreleri açısından regresyon analizinde sadece rekürrens varlığı anlamlı faktör olarak saptandı.
Sonuç: Endometrioit tip endometrium kanserinde rekürrens gelişmesi sürvi açısından en önemli prognostik faktördür. Rekürrensin erken tanı ve tedavisi ile prognoz olumlu yönde etkilenmektedir.

Keywords

endometrioid, endometriyal kanser, rekürrens, survi

Project Number

None

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