COVID-19 Ricochets on Kidney Transplant and Hemodialysis Patients

Year 2023, Volume: 33 Issue: 3, 309 - 315, 30.06.2023

Mevlüt Hakan Göktepe , Hilal Akay Çizmecioglu , Ali Kürşat Tuna , Ahmet Cizmecioglu

https://doi.org/10.54005/geneltip.1251579

Abstract

Background/Aims: An impaired immune response affects Coronavirus 2019 (COVID-19) disease progression. Immunities of both hemodialysis (HD) and Kidney Transplant (KTx) patients have already been suppressed. This study evaluated the prognostic laboratory results in HD and KTx patients with COVID-19.
Methods: This retrospective, case-control study was conducted with PCR (+) COVID-19 HD and KTx patients and a control group. All patients were divided into two subgroups according to disease severity. Patients' demographic records and laboratory results were obtained from the follow-up files.
Results: A total of 30 HD, 20 KTx patients, and 40 control groups were involved in the study. Gender and hospitalization duration did not differ between the groups. There was a 10% mortality rate in the KTx group and 27% in the HD group. Lung involvement in Computed Tomography (CT) was higher in HD patients (47%) than in KTx (25%). In subgroup evaluations, the most prominent laboratory values were fibrinogen in HD patients and LDH and Ferritin in KTx patients in determining disease severity.
Conclusions: Early hospitalization and treatment implementations will be associated with a good prognosis in HD and KTx patients since CT and laboratory results are not predictive in these groups of patients during the COVID-19 pandemic.

Keywords

COVID-19, Disease severity, Hemodialysis, Kidney transplantation

Supporting Institution

None

Böbrek Nakli ve Hemodiyaliz Hastalarında COVID-19 Rikoşeleri

Abstract

Arka Plan/Amaçlar: Bozulmuş bir bağışıklık cevabı, Coronavirüs 2019 (COVID-19) hastalığının prognozunu etkiler. Hem hemodiyaliz (HD) hem de Böbrek Nakli (BN) hastalarının bağışıklıkları zaten baskılıdır. Bu çalışma COVID-19'lu HD ve BN hastalarında prognostik laboratuvar sonuçlarını değerlendirmiştir.
Yöntemler: Bu retrospektif, vaka kontrol çalışması, PCR (+) COVID-19 HD ve BN hastaları ve kontrol grubu ile gerçekleştirildi. Tüm hastalar hastalık şiddetine göre iki alt gruba ayrıldı. Hastaların demografik kayıtları ve laboratuvar sonuçları takip dosyalarından elde edildi.
Bulgular: Çalışmaya toplam 30 HD, 20 BN hastası ve 40 kontrol grubu dahil edildi. Cinsiyet ve hastanede yatış süresi gruplar arasında farklılık göstermedi. BN grubunda %10, HD grubunda %27 ölüm oranı vardı. Bilgisayarlı Tomografide (BT) akciğer tutulumu HD hastalarında (%47) BN'ye (%25) göre daha yüksekti. Alt grup değerlendirmelerinde hastalık şiddetinin belirlenmesinde HD hastalarında fibrinojen, BN hastalarında ise LDH ve Ferritin öne çıkan laboratuvar değerleriydi.
Sonuç: BT ve laboratuvar sonuçları COVID-19 pandemisinde bu tarz hasta gruplarında prediktif olmadığı için erken yatış ve tedavi uygulamaları HD ve BN hastalarında iyi bir prognoz ile ilişkili olacaktır.

Keywords

COVID-19, Böbrek nakli, Hemodiyaliz, Hastalık şiddeti

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