ADVANCED GLYCATION END PRODUCTS AND THEIR RELATIONSHIPS WITH OTHER PROCESSING-RELATED CHEMICAL HAZARDS IN MEAT AND MEAT PRODUCTS
Abstract
Meat processing improves microbial safety, shelf life, and sensory quality but may also promote the formation of chemical compounds of health concern. This review evaluates the formation, occurrence, health effects, and control of advanced glycation end products (AGEs), heterocyclic aromatic amines (HAAs), polycyclic aromatic hydrocarbons (PAHs), and N-nitrosamines (NAs) in meat and meat products, with particular emphasis on AGEs. AGEs and HAAs are mainly associated with the Maillard reaction, whereas PAHs arise from pyrolysis, incomplete combustion, and smoke deposition. NAs are formed through reactions between amine precursors and nitrite-derived nitrosating agents. High temperature, prolonged cooking, surface dehydration, oxidation, direct flame exposure, smoking, and storage conditions influence their formation. Control measures should be considered collectively while maintaining microbial safety and desirable sensory properties. Simultaneous monitoring of multiple hazards can provide a more comprehensive assessment of chemical safety and support the development of meat-processing practices that reduce consumer exposure without compromising product quality.
Keywords
References
- Adeyeye, S. A. O. (2020). Heterocyclic Amines and Polycyclic Aromatic Hydrocarbons in Cooked Meat Products: A Review. Polycyclic Aromatic Compounds, 40(5), 1557-1567. https://doi.org/10.1080/10406638.2018.1559208
- Adeyeye, S. A. O. & Ashaolu, T. J. (2021). Heterocyclic amine formation and mitigation in processed meat and meat products: A mini-review. Journal of Food Protection, 84(11), 1868-1877. https://doi.org/10.4315/JFP-20-471
- Adeyeye, S. A. O. & Ashaolu, T. J. (2022). Polycyclic Aromatic Hydrocarbons Formation and Mitigation in Meat and Meat Products. Polycyclic Aromatic Compounds, 42(6), 3401-3411. https://doi.org/10.1080/10406638.2020.1866039
- Adeyeye, S. A. O., Sivapriya, T. & Sankarganesh, P. (2025). Formation and mitigation of heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) in high temperature processed meat products: a review. Discover Food, 5(1), 258. https://doi.org/10.1007/s44187-025-00391-w
- EFSA Panel; Alexander, J., Benford, D., Cockburn, A., Cravedi, J. P., Dogliotti, E., di Domenico, A., Fernández-Cruz, M. L., Fink-Gremmels, J., Fürst, P., Galli, C., Grandjean, P., Gzyl, J., Heinemeyer, G., Johansson, N., Mutti, A., Schlatter, J., van Leeuwen, R., van Peteghem, C. & Verger, P. (2008). Polycyclic Aromatic Hydrocarbons in Food. EFSA Journal, 724(8), 1-114. https://doi.org/10.2903/j.efsa.2008.724
- Amr, A. K., Hassanin, F. S., Hassan, M. A. & Shaltout, F. A. (2024). Trials to Estimate and Control the Residual Levels of Heterocyclic Aromatic Amines In Meat Products. Assiut Veterinary Medical Journal Assiut Vet. Med. J, 70(182), 98-105. www.aun.edu.eg
- Bai, X., Li, Y., Liang, W., Xia, X. & Bian, C. (2023). Formation of advanced glycation end products of chicken breast meat induced by freeze-thaw cycles and subsequent cooking. International Journal of Biological Macromolecules, 244, 125387. https://doi.org/10.1016/j.ijbiomac.2023.125387
- Bak, K. H., Bauer, S., Eisenreich, C. & Paulsen, P. (2025). Residual Nitrite, Nitrate, and Volatile N-Nitrosamines in Organic and Conventional Ham and Salami Products. Foods, 14, 112. https://doi.org/10.3390/foods14010112
Details
Primary Language
English
Subjects
Meat Technology
Journal Section
Review
Authors
Gülsüme Bıçakcı
*
0000-0002-4901-9787
Türkiye
Early Pub Date
October 22, 2026
Publication Date
-
Submission Date
August 14, 2026
Acceptance Date
October 19, 2026
Published in Issue
Year 2026 Number: Advanced Online Publication