FERMENTE GIDALARIN İNSAN SAĞLIĞI ÜZERİNDEKİ ETKİLERİ

Abstract

Tarihin eski dönemlerinde gıdaları fermente ederek kullanmanın amacı, gıda maddesini daha uzun süre saklayabilmek ya da gıdada çeşitli aroma maddelerini geliştirmek olarak tanımlanmaktadır. Sağlık üzerindeki olumlu etkilerinin anlaşılmasıyla birlikte, fermente gıdalar günümüzde sıklıkla tüketilen gıdalar haline gelmişlerdir. Fermente gıdalar, yararlı mikroorganizmaların katıldığı kontrollü prosesler ile, gıdaların fermantasyona uğraması sonucunda, çeşitli enzimatik değişimlerin ve sağlığa yararlı son ürünlerin meydana geldiği fonksiyonel gıdalar olarak tanımlanmaktadırlar. Fermantasyon sürecinde yer alan mikroorganizmalar, ürettikleri çeşitli metabolitler ve bunların insan sağlığı üzerindeki olumlu etkileri, birçok bilim dalının ilgisini çekmekte ve günümüzde halen, sıklıkla araştırılan konular arasında yer almaktadır. Bu derlemede, fermente ürünlerin ve probiyotik mikroorganizmaların çeşitli fonksiyonel özellikleri üzerinde durularak bunların, insan sağlığı üzerindeki olumlu etkileri ele alınmıştır.

Keywords

• fermente gıdalar
• probiyotik
• prebiyotik
• bağırsak mikrobiyotası
• kronik hastalıklar

THE EFFECTS OF FERMENTED FOODS ON HUMAN HEALTH

Abstract

In ancient times, the purpose of the fermenting foods was identified as keeping the food material for a longer time or improving some aroma compounds in food. With understanding of the positive effects of fermented foods on human health, nowadays they are frequently consumed. Fermented foods are defined as functional foods which involve in controlled processes of beneficial microorganisms. As a result of fermentation, various enzymatic changes and healthful end products are formed. Microorganisms acting on fermentation, their several metabolites and positive effects on human health attract many disciplines and recently all are often investigated. In this review, by emphasizing the functional properties of fermented foods and probiotic microorganisms, their positive effects on human health are discussed.

Keywords

• fermented foods
• probiotics
• prebiotics
• gut microbiota
• chronic diseases

References

1. Aguilar-Toalá, J., Santiago-López, L., Peres, C., Peres, C., Garcia, H., Vallejo-Cordoba, B., González-Córdova, A., & Hernández-Mendoza, A. (2017). Assessment of multifunctional activity of bioactive peptides derived from fermented milk by specific Lactobacillus plantarum strains. J Dairy Sci, 100(1), 65-75. doi:10.3168/jds.2016-11846
2. Ahmad, V., Khan, M. S., Jamal, Q. M. S., Alzohairy, M. A., Al Karaawi, M. A., & Siddiqui, M. U. (2017). Antimicrobial potential of bacteriocins: in therapy, agriculture and food preservation. Int J Antimicrob Agents, 49(1), 1-11. doi:10.1016/j.ijantimicag.2016.08.016
3. Akdeniz, V., Akalın, A. S., & Özer, E. (2018). Helicobacter pylori enfeksiyonunda probiyotiklerin rolü. Gıda, 43(6), 943-956. doi:10.15237/gida.GD18062
4. Alp, D., & Ertürkmen, P. (2017). Probiyotik olarak kullanılan Lactobacillus spp. suşlarının kolesterol düşürücü etkileri ve olası mekanizmalar. MAKÜ Sag Bil Enst Derg, 8(1), 108-113.
5. Alp, D., & Kuleaşan, H. (2019). Farklı kaynaklardan izole edilmiş laktik asit bakterilerinin ekzopolisakkarit üretimi ve kolesterol asimilasyon yeteneklerinin belirlenmesi. Gıda, 44(2), 191-201. doi:10.15237/gida.GD18059
6. Alvarez-Sieiro, P., Montalbán-López, M., Mu, D., & Kuipers, O. P. (2016). Bacteriocins of lactic acid bacteria: extending the family. Appl Microbiol Biotechnol, 100(7), 2939-2951. doi:10.1007/s00253-016-7343-9
7. Asghar, F., Ali, S., Goraya, A., Javaid, I., & Hussain, Z. (2017). A Review on the Role of Fermented Foods as Health Promoters. Int J Sci Eng Technol, 3, 141-148. doi:10.32628/IJSRST173415
8. Aslam, H., Green, J., Jacka, F. N., Collier, F., Berk, M., Pasco, J., & Dawson, S. L. (2018). Fermented foods, the gut and mental health: A mechanistic overview with implications for depression and anxiety. Nutr Neurosci, 1-13. doi:10.1080/1028415X.2018

9. Asunis, F., De Gioannis, G., Isipato, M., Muntoni, A., Polettini, A., Pomi, R., Rossi, A., & Spiga, D. (2019). Control of fermentation duration and pH to orient biochemicals and biofuels production from cheese whey. Bioresour Technol, 289, 121722. doi:10.1016/j.biortech.2019.121722
10. Ay, C., & Şanlı, T. (2018). Süt Ürünlerinde Biyoaktif Peptitlerin Oluşumu ve Fonksiyonel Özellikleri. ADÜ Ziraat Derg, 15(1), 115-120. doi:doi.org/10.25308/aduziraat.340581
11. Bagarolli, R. A., Tobar, N., Oliveira, A. G., Araújo, T. G., Carvalho, B. M., Rocha, G. Z., Vecina, J. F., Calisto, K., Guadagnini, D., & Prada, P. O. (2017). Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice. J Nutr Biochem, 50, 16-25. doi:10.1016/j.jnutbio.2017.08.006
12. Beltrán-Barrientos, L. M., Hernández-Mendoza, A., González-Córdova, A. F., Astiazarán-García, H., Esparza-Romero, J., & Vallejo-Córdoba, B. (2018). Mechanistic pathways underlying the antihypertensive effect of fermented milk with Lactococcus lactis NRRL B-50571 in spontaneously hypertensive rats. Nutrients, 10(3), 262. doi:10.3390/nu10030262
13. Boulangé, C. L., Neves, A. L., Chilloux, J., Nicholson, J. K., & Dumas, M.-E. (2016). Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med, 8(1), 1-12. doi:10.1186/s13073-016-0303-2.
14. Caggianiello, G., Kleerebezem, M., & Spano, G. (2016). Exopolysaccharides produced by lactic acid bacteria: from health-promoting benefits to stress tolerance mechanisms. Appl Microbiol Biotechnol, 100(9), 3877-3886. doi:10.1007/s00253-016-7471-2
15. Çetinbaş, S., Kemeriz, F., Göker, G., Biçer, İ., & Velioğlu, Y. S. (2017). İnsan Mikrobiyomu: Beslenme ve Sağlık Üzerindeki Etkileri. Akademik Gıda, 15(4), 409-415. doi:10.24323/akademik-gida.370267
16. Chikindas, M. L., Weeks, R., Drider, D., Chistyakov, V. A., & Dicks, L. M. (2018). Functions and emerging applications of bacteriocins. Curr Opin Biotechnol, 49, 23-28. doi:10.1016/j.copbio.2017.07.011
17. Coretti, L., Paparo, L., Riccio, M., Amato, F., Cuomo, M., Natale, A., Borrelli, L., Corrado, G., Comegna, M., & Buommino, E. (2018). Gut microbiota features in young children with autism spectrum disorders. Front Microbiol, 9, 3146. doi:10.3389/fmicb.2018.03146
18. Daliri, E., Oh, D., & Lee, B. (2017). Bioactive peptides. Foods, 6(5), 32. doi:10.3390/foods6050032.
19. Deka, S. C., Seth, D., & Hulle, N. R. S. (Eds.). (2020). Food Bioactives: Functionality and Applications in Human Health. USA: CRC Press.
20. Demirgül, F., & Sağdıç, O. (2017). Laktik Starter Kültür Üretim Teknolojisi. Avrupa Bilim ve Teknoloji Dergisi, 7(11), 27-37.
21. Dimidi, E., Cox, S. R., Rossi, M., & Whelan, K. (2019). Fermented Foods: Definitions and characteristics, impact on the gut microbiota and effects on gastrointestinal health and disease. Nutrients, 11(8), 1806. doi:10.3390/nu11081806
22. Dinan, T. G., & Cryan, J. F. (2017). The microbiome-gut-brain axis in health and disease. Gastroentol Clin N, 46(1), 77-89. doi:10.1016/j.gtc.2016.09.007
23. Doğan, A., Yaşar, S., Kayhan, S., Kırmızıgöz, Ş., & Kaplan, A. (2018). Bağırsak-beyin aksı. Türk Nöroşir Derg, 28(3), 377-379. doi:10.5336/jtracom.2018-61683
24. Durmuş, E., Aypak, C., & Görpelioğlu, S. (2018). Tip 2 Diyabet Hastalarında Kronik İnflamasyon Belirteci Olarak Lökosit Sayımı. Ankara Med J, 1(4), 253-259. doi:1017098/amj.364164
25. Fatih, K. (2017). Bağırsak Mikrobiyotasının Obezite, İnsülin Direnci ve Diyabetteki Rolü. J Biotechnol and Strategic Health Res, 1, 68-80.
26. Foster, J. A., Rinaman, L., & Cryan, J. F. (2017). Stress & the gut-brain axis: regulation by the microbiome. Neurobiol Stress, 7, 124-136. doi:10.1016/j.ynstr.2017.03.001
27. Frias, J., Martinez-Villaluenga, C., & Peñas, E. (2016). Fermented Foods in Health and Disease Prevention. United Kingdom: Elsevier.
28. Ghaisas, S., Maher, J., & Kanthasamy, A. (2016). Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacol Ther, 158, 52-62. doi:10.1016/j.pharmthera.2015.11.012
29. Gutiérrez, S., Martínez-Blanco, H., Rodríguez-Aparicio, L., & Ferrero, M. (2016). Effect of fermented broth from lactic acid bacteria on pathogenic bacteria proliferation. J Dairy Sci, 99(4), 2654-2665. doi:10.3168/jds.2015-10439
30. Holban, A. M., & Grumezescu, A. M. (Eds.). (2018). Diet, Microbiome and Health (Vol. 11). UK: Elsevier.
31. Holscher, H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes, 8(2), 172-184. doi:10.1080/19490976.2017.1290756
32. Iskandar, C. F., Cailliez-Grimal, C., Borges, F., & Revol-Junelles, A.M. (2019). Review of lactose and galactose metabolism in Lactic Acid Bacteria dedicated to expert genomic annotation. Trends Food Sci Technol. doi:10.1016/j.tifs.2019.03.020
33. Kim, D. H., Jeong, D., Song, K. Y., & Seo, K. H. (2018). Comparison of traditional and backslopping methods for kefir fermentation based on physicochemical and microbiological characteristics. LTW, 97, 503-507. doi:10.1016/j.lwt.2018.07.023
34. Kim, J. E., Kim, M. S., Yoon, Y. S., Chung, M. J., & Yum, D. Y. (2014). Use of selected lactic acid bacteria in the eradication of Helicobacter pylori infection. J Microbiol, 52(11), 955-962. doi:10.1007/s12275-014-4355-y
35. Kıvanç, M., & Kovancı, P. (2017). Fermente gıdalardan izole edilen laktik asit bakterilerinin antifungal aktivitesinin belirlenmesi. Gıda, 42(5), 477-484. doi:10.15237/gida.GD17012
36. Koçak, Y., Fındık, A., & Çiftçi, A. (2016). Probiyotikler: Genel Özellikleri ve Güvenilirlikleri. Etlik Vet Mikrobiyol Derg, 27(2), 118-122.
37. Lee, C., & Pan, T. (2017). The prevention of Alzheimer’s disease and Parkinson’s disease by Monascus purpureus NTU 568–fermented compounds. J Alzheimers Dis Parkinsonism, 7(342), 2161-0460.1000342. doi:10.4172/2161-0460.1000342
38. Leroy, F., & De Vuyst, L. (2016). Advances in production and simplified methods for recovery and quantification of exopolysaccharides for applications in food and health. J Dairy Sci, 99(4), 3229-3238. doi:10.3168/jds.2015-9936
39. Levent, H., & Cavuldak, Ö. A. (2017). Geleneksel Fermente Bir İçecek: Boza. Akademik Gıda, 15(3), 300-307. doi:10.24323/akademik-gida.345273
40. Li, C., Kwok, L. Y., Mi, Z., Bala, J., Xue, J., Yang, J., Ma, Y., Zhang, H., & Chen, Y. (2017). Characterization of the angiotensin-converting enzyme inhibitory activity of fermented milks produced with Lactobacillus casei. J Dairy Sci, 100(12), 9495-9507. doi:10.3168/jds.2017-12970
41. Li, Q., & Zhou, J. M. (2016). The microbiota–gut–brain axis and its potential therapeutic role in autism spectrum disorder. Neuroscience, 324, 131-139. doi:10.1016/j.neuroscience.2016.03.013
42. Marco, M. L., Heeney, D., Binda, S., Cifelli, C. J., Cotter, P. D., Foligné, B., Gänzle, M., Kort, R., Pasin, G., & Pihlanto, A. (2017). Health benefits of fermented foods: microbiota and beyond. Curr Opin Biotechnol, 44, 94-102. doi:10.1016/j.copbio.2016.11.010
43. Markowiak, P., & Śliżewska, K. (2017). Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients, 9(9), 1021. doi:10.3390/nu9091021
44. Medina, R. (2019). Fermentation Technology. United Kingdom: ED-TECH Press.
45. Min, M., Bunt, C. R., Mason, S. L., & Hussain, M. A. (2019). Non-dairy probiotic food products: An emerging group of functional foods. Crit Rev Food Sci Nutr, 59(16), 2626-2641. doi: 10.1080/10408398.2018.1462760
46. Mokoena, M. P., Mutanda, T., & Olaniran, A. O. (2016). Perspectives on the probiotic potential of lactic acid bacteria from African traditional fermented foods and beverages. Food Nutr Res, 60(1), 29630. doi:10.3402/fnr.v60.29630
47. Mota de Carvalho, N., Costa, E., Silva, S., Pimentel, L., Fernandes, T., & Pintado, M. (2018). Fermented foods and beverages in human diet and their influence on gut microbiota and health. Fermentation, 4(4), 90. doi:10.3390/fermentation4040090
48. Oğuz, Ş., & Andiç, S. (2019). Peynir üretiminde kullanilan starter kültürler. Gıda, 44(6), 1174-1196. doi:10.15237/gida.GD19121
49. Özdemir, A., & Demirel, Z. B. (2017). Beslenme ve Mikrobiyota ilişkisi. J Biotechnol and Strategic Health Res, 1, 25-33.
50. Potočnjak, M., Pušić, P., Frece, J., Abram, M., Janković, T., & Gobin, I. (2017). Three new Lactobacillus plantarum strains in the probiotic toolbox against gut pathogen Salmonella enterica serotype Typhimurium. Food Technol Biotechnol, 55(1), 48-54. doi:10.17113/ftb.55.01.17.4693
51. Russo, P., Arena, M. P., Fiocco, D., Capozzi, V., Drider, D., & Spano, G. (2017). Lactobacillus plantarum with broad antifungal activity: A promising approach to increase safety and shelf-life of cereal-based products. Int J Food Microbiol, 247, 48-54. doi:10.1016/j.ijfoodmicro.2016.04.027
52. Şanlier, N., Gökcen, B. B., & Sezgin, A. C. (2019). Health benefits of fermented foods. Crit Rev Food Sci Nutr, 59(3), 506-527. doi: 10.1080/10408398.2017.1383355
53. Serra, D., Almeida, L. M., & Dinis, T. C. (2019). The Impact of Chronic Intestinal Inflammation on Brain Disorders: the Microbiota-Gut-Brain Axis. Mol Neurobiol, 1-11. doi:10.1007/s12035-019-1572-8
54. Sugeçti, S., Büyükgüzel, E., & Büyükgüzel, K. (2019). Barsak Mikrobiyotasının Nörodejeneratif Hastalıklar Üzerindeki Patofizyolojik Rolü. J Immunol Clin Microbiol, 4(4), 152-157.
55. Tamang, J., Watanabe, K., & Holzapfel, W. (2016). Review: Diversity of microorganisms in global fermented foods and beverages. Front Microbiol. 2016; 7: 377. Front Microbiol, 7(337). doi:10.3389/fmicb.2016.00377
56. Tan, D. T., Poh, P. E., & Chin, S. K. (2018). Microorganism preservation by convective air-drying—A review. Drying Technology, 36(7), 764-779. doi:10.1080/07373937.2017.1354876
57. Thursby, E., & Juge, N. (2017). Introduction to the human gut microbiota. Biochem J, 474(11), 1823-1836. doi:10.1042/BCJ20160510
58. Tseng, C. H., & Wu, C. Y. (2019). The gut microbiome in obesity. J Formosan Med Assoc, 118, S3-S9. doi:10.1016/j.jfma.2018.07.009
59. Tseng, W. T., Hsu, Y. W., & Pan, T. M. (2016). The ameliorative effect of Monascus purpureus NTU 568-fermented rice extracts on 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells and the rat model of Parkinson's disease. Food Funct, 7(2), 752-762. doi:10.1039/C5FO00976F
60. Vinicius De Melo Pereira, G., De Carvalho Neto, D. P., Junqueira, A. C. D. O., Karp, S. G., Letti, L. A., Magalhães Júnior, A. I., & Soccol, C. R. (2019). A Review of Selection Criteria for Starter Culture Development in the Food Fermentation Industry. Food Rev Int, 1-33. doi:10.1080/87559129.2019.1630636
61. Vítor, J. M., & Vale, F. F. (2011). Alternative therapies for Helicobacter pylori: probiotics and phytomedicine. FEMS Immunology & Medical Microbiology, 63(2), 153-164. doi:10.1111/j.1574-695X.2011.00865.x
62. Wong, C. B., Odamaki, T., & Xiao, J. Z. (2019). Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health: Modulation of gut microbiome as the principal action. J Funct Foods, 54, 506-519. doi:10.1016/j.jff.2019.02.002
63. Yalçın, H., & Üstündağ, H. (2017). Bacteriocins and their use in food products. MAKÜ Sag Bil Enst Derg, 5(1), 53-65. doi:10.24998/maeusabed.299346
64. Zannini, E., Waters, D. M., Coffey, A., & Arendt, E. K. (2016). Production, properties, and industrial food application of lactic acid bacteria-derived exopolysaccharides. Appl Microbiol Biotechnol, 100(3), 1121-1135. doi:10.1007/s00253-015-7172-2
65. Zhao, W., Liu, Y., Latta, M., Ma, W., Wu, Z., & Chen, P. (2019). Probiotics database: a potential source of fermented foods. Int J Food Prop, 22(1), 198-217. doi:10.1080/10942912.2019.1579737