Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü

Kübra Tütüncü; Hatice Karaboduk

doi:10.63716/guffd.1762655

Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü

Öz

Kadmiyum (Cd), birçok endüstriyel alanda kullanımıyla çevrede yaygın olarak bulunan oldukça toksik ağır metallerden birisidir ve hem insan hem de hayvan sağlığı açısından ciddi bir tehdit oluşturmaktadır. Berberin (BBR), antikanser antioksidan ve antiinflamatuar etkileri bulunan, bitkisel kaynaklı doğal bir antioksidandır. Bu çalışmada kadmiyum klorürün (CdCl2) ratların akciğer dokusunda yarattığı toksik etkiye karşı berberinin koruyucu rolü araştırılmıştır. Ratlar her grupta rastgele altı birey olacak şekilde 4 gruba ayrılmıştır. Kontrol grubu, BBR grubu (30 mg/kg v.a.), CdCl2 grubu (1,76 mg/kg v.a.) ve BBR+CdCl2 grubu. 28 günlük uygulama sonrasında, kontrol grubuna göre CdCl2 uygulanan ratların akciğer dokularında Cd birikiminde ve MDA seviyelerinde anlamlı bir artış, SOD, CAT, GST ve GPx antioksidan enzim aktivitelerinde ise anlamlı bir azalma gözlenmiştir (p<0,05). Ayrıca, CdCl2’nin akciğer dokularında histopatolojik değişikliklere neden olduğu gözlenmiştir. Berberin ile birlikte CdCl2 uygulanan grup ile CdCl2 grubu karşılaştırıldığında akciğer dokularındaki Cd birikimi ve MDA seviyesi azalırken, antioksidan enzim aktivitelerinde anlamlı bir artış tespit edilmiştir. Bulgularımız, berberinin oksidatif stres kaynaklı toksik etkilere karşı potansiyel bir terapötik ajan olabileceğini göstermektedir.

Anahtar Kelimeler

Etik Beyan

Tüm deneysel prosedürler Gazi Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu tarafından onaylanmıştır (G.Ü.ET-24.132).

Teşekkür

Çalışmamızın hayvan deneyleri kısmını FYL-2024-9655 no’lu pojeden destekleyen Gazi Üniversitesi Bilimsel Araştırma Projeleri birimine teşekkür ederiz. Bu çalışma, Gazi Üniversitesi Fen Bilimleri Enstitüsü Biyoloji Anabilim Dalında, “Kadmiyum’un Rat Akciğer Dokusu Üzerine Toksik Etkisi Ve Berberin’in Koruyucu Rolü” isimli yüksek lisans tezinden türetilmiştir.

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Hayvan Fizyolojisi - Ekofizyoloji

Bölüm

Araştırma Makalesi

Yazarlar

Kübra Tütüncü
0009-0007-1157-579X
Türkiye

Hatice Karaboduk ^*
0000-0001-6752-7219
Türkiye

Yayımlanma Tarihi

29 Kasım 2025

Gönderilme Tarihi

11 Ağustos 2025

Kabul Tarihi

16 Ekim 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 6 Sayı: 2

DOI

https://doi.org/10.63716/guffd.1762655

IZ

https://izlik.org/JA36BR79SP

Kaynak Göster

RIS / Bibtex

APA

Tütüncü, K., & Karaboduk, H. (2025). Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü. Gazi Üniversitesi Fen Fakültesi Dergisi, 6(2), 265-274. https://doi.org/10.63716/guffd.1762655

AMA

1.Tütüncü K, Karaboduk H. Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü. GÜFFD. 2025;6(2):265-274. doi:10.63716/guffd.1762655

Chicago

Tütüncü, Kübra, ve Hatice Karaboduk. 2025. “Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü”. Gazi Üniversitesi Fen Fakültesi Dergisi 6 (2): 265-74. https://doi.org/10.63716/guffd.1762655.

EndNote

Tütüncü K, Karaboduk H (01 Kasım 2025) Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü. Gazi Üniversitesi Fen Fakültesi Dergisi 6 2 265–274.

IEEE

[1]K. Tütüncü ve H. Karaboduk, “Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü”, GÜFFD, c. 6, sy 2, ss. 265–274, Kas. 2025, doi: 10.63716/guffd.1762655.

ISNAD

Tütüncü, Kübra - Karaboduk, Hatice. “Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü”. Gazi Üniversitesi Fen Fakültesi Dergisi 6/2 (01 Kasım 2025): 265-274. https://doi.org/10.63716/guffd.1762655.

JAMA

1.Tütüncü K, Karaboduk H. Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü. GÜFFD. 2025;6:265–274.

MLA

Tütüncü, Kübra, ve Hatice Karaboduk. “Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü”. Gazi Üniversitesi Fen Fakültesi Dergisi, c. 6, sy 2, Kasım 2025, ss. 265-74, doi:10.63716/guffd.1762655.

Vancouver

1.Kübra Tütüncü, Hatice Karaboduk. Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü. GÜFFD. 01 Kasım 2025;6(2):265-74. doi:10.63716/guffd.1762655