Etofenprox’un Genotoksik Etkisinin Drosophila melanogaster’de Değerlendirilmesi

Yıl 2024, Cilt: 5 Sayı: 1, 21 - 30, 29.05.2024

Selda Öz , Serap Kocaoğlu Cenkci

Öz

Tarım ve halk sağlığında yaygın kullanılan piretroid insektisitlerden etofenprox ülkemizde en sık maruz kalınan insektisitlerdendir. İnsektisitlere maruziyet insanlarda ve diğer hedef dışı organizmalarda ciddi boyutlara varabilen olumsuz etkilere yol açabilmektedir. Bu çalışmada etofenprox’un model organizma Drosophila melanogaster üzerinde genotoksik etki potansiyelinin araştırılması amaçlanmıştır. Genotoksik etkinin değerlendirilmesinde somatik mutasyon ve rekombinasyon testi (SMART) kullanılmıştır. SMART analizinde etofenprox’un subletal dozlarına (0,625; 1; 1,25 ve 2,5 ppm) maruz bırakılan transheterozigot larvalardan gelişen ergin bireylerin kanatlarında meydana gelen fenotipik değişiklikler incelenmiştir. Elde edilen veriler, etofenprox’un test edilen tüm dozlarda toplam klon sayısında istatistiksel olarak pozitif artışa neden olarak genotoksisiteyi indüklediğini göstermiştir.

Anahtar Kelimeler

Etofenprox,, genotoksisite,, insektisit,, SMART.

Etik Beyan

Bu çalışma etik kurul izni veya herhangi bir özel izin gerektirmez.

Kaynakça

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