The Effects of Potassium Bromate and Resveratrol on Fatty Acid Levels in Heart, Muscle and Brain of Wistar Rats

Year 2011, Volume: 24 Issue: 2, 181 - 186, 05.04.2011

Serhat Keser , Okkes Yılmaz Mehmet Tuzcu

Abstract

The aim of this study was to examine the effects of antioxidant resveratrol and carcinogen KBrO₃ on the level of fatty acids in heart, muscle and brain of old female Wistar rats. In this study Wistar rats were randomly divided into three groups: 1. Control (C), 2. KBrO₃ (P) (80 mg/kg, i.p. single dose) 3. Resveratrol+KBrO₃ (Res) (80 mg/kg KBrO₃ i.p. single dose, 33 mg/kg resveratrol, every other day, for 35 days). In heart, muscle and brain, fatty acid levels were measured by gas chromatography.

 

In the present study, palmitoleic acid (16:1) and oleic acid (18:1) levels were significantly increased in the P and Res groups (p<0.05, p<0.001, respectively). Stearic acid (18:0) and docosahexaenoic acid (22:6) levels were significantly decreased in the P and Res groups (p<0.01, p<0.05, respectively) in the heart. Palmitoleic acid (16:1), oleic acid (18:1) and linolenic acid (18:3) levels were significantly increased in the P and Res groups (p<0.01, p<0.001, p<0.05, respectively). Docosahexaenoic acid (22:6) level was decreased in the P and Res groups (p<0.05) in the muscle. Palmitoleic acid (16:1) and stearic acid (18:0) levels were decreased in the Res group (p<0.05) in the brain. Our results confirm that resveratrol and KBrO₃ treatment were affected the amount of important fatty acids which substrates in fatty acids metabolism of heart, muscle and brain of Wistar rats.

Key Words: Resveratrol, KBrO₃, Heart, Muscle, Brain.

 

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Keywords

Resveratrol, KBrO3, Heart, Muscle, Brain

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