Diyabetik Retinopati Hastalarında Vitreus Humor Değişikliklerinin Bilgisayarlı Tomografi ile Değerlendirilmesi

Year 2025, Volume: 14 Issue: 3, 1227 - 1232, 25.09.2025

Emre Aydın , İsmet Miraç Çakır , Enes Gürün , Şaban Kılıç , Mesut Ozturk

https://doi.org/10.37989/gumussagbil.1730131

Abstract

Görme kaybının önde gelen nedenlerinden biri olan diyabetik retinopati (DR), retina mikrovasküler hasarı ve vitreus humorundaki yapısal değişikliklerle ilişkilidir. Yüksek çözünürlüklü bilgisayarlı tomografi (BT) görüntüleme, vitreus humor yoğunluğundaki değişikliklerin hassas ve noninvaziv bir şekilde değerlendirilmesini sağlar. Bu çalışmanın amacı, DR hastalarının vitreus humorundaki değişiklikleri BT kullanarak değerlendirmektir.
1 Ocak 2022 ile 1 Haziran 2024 tarihleri arasında beyin BT'si yapılan ve görüntüleri radyoloji bilgi sisteminde bulunan 18 yaş ve üzeri DR hastaları retrospektif olarak incelenmiştir. 50 DR hastası ve yaş ve cinsiyet açısından eşleştirilmiş 50 diyabetik olmayan kontrol hastası çalışmaya dahil edildi. DR hastalarının vitreus sıvısı BT dansite değerleri, kontrol grubunun değerleriyle istatistiksel olarak karşılaştırıldı.
DR ve kontrol gruplarında her iki gözde vitreus sıvı dansitesi açısından cinsiyetler arasında istatistiksel olarak anlamlı bir fark yoktu (p>0,05). DR grubu, kontrol grubuna kıyasla hem sağ hem de sol gözde anlamlı olarak daha yüksek vitreus dansite sergilemiştir (sırasıyla p=0,011, p=0,007). DR ve kontrol gruplarında her iki gözde yaş ve vitreus dansite arasında negatif bir korelasyon bulunmuştur; ancak istatistiksel olarak anlamlı bir fark bulunmamıştır (p>0,05).
BT ölçümleri, vitreus dansitenin DR hastalarında kontrol grubuna göre anlamlı olarak daha yüksek olduğunu ortaya koydu, bu da artan vitreus dansitenin diyabetik retinopati şiddetinin veya ilerlemesinin potansiyel bir belirteci olabileceğini düşündürmektedir.

Keywords

Diyabetik retinopati , bilgisayarlı tomografi , vitreus humor

Evaluation of Vitreous Humor Changes in Patients with Diabetic Retinopathy via Computed Tomography

Abstract

Diabetic retinopathy (DR), a leading cause of blindness, is associated with retinal microvascular damage and structural changes in the vitreous humor. High-resolution computed tomography (CT) imaging allows sensitive and noninvasive assessment of changes in vitreous humor density. The objective of this study was to use CT to evaluate changes in the vitreous humor of patients with DR.
DR patients aged 18 years and older who underwent brain CT between January 1, 2022, and June 1, 2024, and whose images were available in the radiological information system were retrospectively reviewed. Fifty DR patients and 50 age- and gender-matched non-diabetic controls were included. The vitreous humor CT density values of DR patients were statistically compared with those of the control group.
There was no statistically significant difference between the genders in terms of vitreous humor density in both eyes in the DR and control groups (p>0.05). The DR group exhibited significantly higher vitreous humor density in both the right and left eyes compared to the control group (p=0.011, p=0.007, respectively). A negative correlation was found between age and vitreous humor density in both eyes in the DR and control groups; however, no statistically significant difference was found (p>0.05).
CT measurements revealed that vitreous humor density was significantly higher in DR patients than in the control group, suggesting that increased vitreous density may serve as a potential marker for diabetic retinopathy severity or progression.

Keywords

Diabetic retinopathy , computed tomography , vitreous humor

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