Yoğun bakımda COVID-19 Pnömonisi olan SARS-COV-2 RT-PCR Pozitif ve Negatif Hastalarin Karşılaştırılması

Year 2022, , 84 - 88, 29.10.2022

Duygu Kayar Calili , Nurten Arslan , Ismaıl Turkoz , Gılman Tugce Tutkun , Emine Geçkil , Murat Altuntas , Fasıme Ozge Aygun Kas , Umıt Gemıcı

https://doi.org/10.52827/hititmedj.1125430

Abstract

Amaç: Yoğun bakıma kabul edilen RT-PCR pozitif ve toraks tomografisinde Coronavirüs-19 pnömonisi bulguları olan RT-PCR negatif hastaları sağkalım ve laboratuvar sonuçları açısından karşılaştırmayı amaçladık.
Gereç ve Yöntem: Solunum yetmezliği ile kabul edilen, görüntülemede tipik pnömoni bulguları olan hastalar çalışmaya alındı. Hastalar RT-PCR negatif ve RT-PCR pozitif olarak gruplandı. Gruplar tanımlayıcı özellikler, sağkalım, laboratuvar, tedaviler, yatış süreleri açısından karşılaştırıldı.
Bulgular: RT-PCR positif grubun Lactat, D-dimer, lökosit, nötrofil sayıları diğer gruptan düşük (p<0.05), Ferritin ve CRP değerleri yüksekti (p<0.01). Semptom başlangıcı ve kabul arasındaki süre PCR-pozitif grupta yüksekti (p=0.016). RT-PCR negatif grupta PaO2/FiO2 oranı 193.58±60.26, RT-PCR pozitif grupta 111.16±58.51 bulundu (p=0.01). Gruplar arasında yatış süreleri, solunum tedavileri ve sağkalım açısından fark yoktu (p>0.05).
Sonuç: Grupların yoğun bakıma kabullerinde farklı inflamasyon fazlarında olabileceklerini düşünmekteyiz ancak sağkalım açısından gruplar arası farklılık olmadığını gördük.

Keywords

COVID-19, pnömoni, revers transkriptaz, yoğun bakım

Supporting Institution

YOK

Comparison of SARS-CoV-2 RT-PCR Positive and Negative Patients with COVID-19 Pneumonia in Intensive Care Unit

Abstract

Aim: We aimed to compare RT-PCR positive and RT-PCR negative patients with radiologically confirmed COVID-19 pneumonia admitted to the intensive care unit (ICU) in terms of outcome and laboratory results in the inflammation process.
Material / Method: Patients who were admitted to the ICU due to respiratory failure and had typical COVID-19 pneumonia findings on thorax tomography were included in the study. Patients were grouped as RT-PCR negative and RT-PCR positive. Groups were compared for descriptive and laboratory characteristics, treatments, length of stay and outcome.
Results: Lactate, D-dimer levels, and leukocyte, neutrophil counts of the RT-PCR positive group were lower than the other group (p<0.05). Ferritin and CRP values were higher in the RT-PCR positive group (p<0.01). The duration between symptom onset and admission to ICU was longer in the PCR-positive group(p=0.016). PaO2/FiO2 ratio was 193.58±60.26 in RT-PCR negative group, and 111.16±58.51 in RT-PCR positive group (p=0.01). There was no statistically significant difference between the groups in terms of length of stay, respiratory therapies or outcome (p>0.05).
Conclusion: We may say that RT-PCR negative and RT-PCR positive patients were in different inflammation period in admission. We concluded that there was no difference between groups in terms of outcome.

Keywords

COVID-19, Intensive care unit, pneumonia, reverse transcriptase

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