SARS-CoV-2 İlişkili Pediatrik Ensefalit Olgusu

Year 2022, , 129 - 131, 29.10.2022

Erkut Etçioğlu , Muhammet Raşit Aydın , Hülya Yaşar Esin Olgun Hasan Apaydın

https://doi.org/10.52827/hititmedj.964801

Abstract

COVID-19'a neden olan SARS-CoV-2, insan hücrelerini enfekte etmek için anjiyotensin dönüştürücü enzim 2 (ACE-2) reseptörüne bağlanır. Beyindeki glial hücreler ve nöronlar; ACE-2 reseptörü içerdiğinden dolayı SARS-CoV-2'nin potansiyel hedeflerindendir. Bu durum SARS-CoV-2’ye nörotrofik bir özellik sağlar. Ensefalit, enfeksiyonun veya vücudun immün savunmasının neden olduğu beyin parankiminin inflamasyonu olarak tanımlanır. Bu yazıda değerlendirmeler sonucunda SARS-CoV-2 ile ilişkili olabileceği düşünülen, bilinç kaybı ve tepkisizlik ile getirilen ensefalit olgusu sunuldu.

Keywords

COVID-19, ensefalit, nörotrofik, SARS-CoV-2

A Case of SARS-CoV-2 Associated Pediatric Encephalitis

Abstract

SARS-CoV-2, which causes COVID-19, binds to the angiotensin-converting enzyme 2 (ACE-2) receptor to infect human cells. Glial cells, and neurons in the brain have been reported to contain ACE-2 receptors, making them potential targets of SARS-CoV-2. This provides neurotrophic properties to the SARS-CoV-2. Encephalitis is defined as inflammation of the brain parenchyma caused by an infection or the body's immune defenses. In this article, we present a case of encephalitis, which was brought with cognitive impairment and decreased responsiveness, which may be associated with SARS-CoV-2 as a result of the evaluations.

Keywords

COVID-19, encephalitis, neurotrophic, SARS-CoV-2

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