PREPARATION, CHARACTERIZATION and DRUG RELEASE BEHAVIOR OF A CLINOPTIOLITE INCORPORATED POLYACRYLAMIDE GRAFTED GELATIN NANOCOMPOSITE IN SITU HYDROGEL

Abstract

In this study, the novel gelatin based in situ hydrogel nanocomposites were prepared from incorporating clinoptiolite (CL) and Lidocaine (LD) as a model local anesthetic drug within polyacrylamide-g-gelatin (PA-g-GA) hydrogel during the synthesis by free radical polymerization. The prepared PA-g-GA, PA-g-GA/CL and drug loaded PA-g-GA/CL in situ hydrogel nanocomposites were analyzed by FTIR and SEM. The drug release behavior of the synthesized composite hydrogel was investigated with UV-Vis spectrophotometry. Swelling and drug release behavior of the new prepared hydrogel nanocomposites were investigated with different CL and drug content in the gel structure. FTIR and SEM analysis revealed that the LD loaded PA-g-GA/CL nanocomposite was successfully prepared. Drug release (%) decreased when the drug loading and CL amount in the composite increased. Various kinetic models for all drug release data were applied in order to study drug release behavior. Korsmeyer-Peppas model fitted for the drug release data of all samples. Swelling, drug release properties of the new nanocomposites were improved with the incorporation of clinoptiolite in the gel structure.

Keywords

• Gelatin
• acrylamide
• clinoptiolite
• nanocomposite

KLİNOPTİOLİT İÇERİKLİ POLİAKRİLAMİD İLE GRAFTLANMIŞ JELATİN NANOKOMPOZİT HİDROJELİNİN SENTEZİ, KARAKTERİZASYONU ve İLAÇ SALIM DAVRANIŞI

Abstract

Bu çalışmada, jelatin (GA), akrilamid (AAm), klinoptiolit (CL) ve model anestetik ilaç Lidokain (LD)’den oluşan yeni tip jelatin bazlı kompozit hidrojeli serbest radikal polimerizasyon ile hazırlandı. Sentezlenen poliakrilamid ile graftlanmış jelatin (PA-g-GA), CL içerikli PA-g-GA ve ilaç yüklü PA-g-GA/CL kompozit hidrojellerinin karakterizasyonu FTIR ve SEM kullanılarak yapıldı. Sentezlenen yenkompozit hidrojelin ilaç salım davranışı, UV-Vis spektrofotometri ile incelendi. Farklı CL miktarı ve farklı ilaç konsantrasyon içeriklerinde sentezlenen yeni tip nanokompozit hidrojellerin, şişme ve ilaç salım davranışları incelendi. FTIR ve SEM analizleri, PA-g-GA/CL kompozit hidrojelinin başarıyla sentezlendiğini ve LD ilacıyla yüklendiğini ortaya koydu. Kompozitteki ilaç yükleme ve CL miktarı arttıkça LD salınımı (%) azalmıştır. İlaç salınım davranışını incelemek için LD salınım verilerine çeşitli kinetik modellere uyarlandı. Hazırlanan tüm hidrojellerin ilaç salımı Korsmeyer-Peppas modeline uymaktadır. Yeni nanokompozitlerin şişme ve ilaç salım özellikleri, jel yapısına klinoptiolitin eklenmesiyle geliştirildi.

Keywords

• Jelatin
• akrilamid
• klinoptiolit
• nanokompozit.

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