Review
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NFC Tabanlı Giyilebilir Elektrokimyasal Sensörlerin Geleceği: Biyobelirteç Takibi ve Kablosuz İletişimi Entegre Eden Bir İnceleme

Year 2026, Volume: 54 Issue: 2 , 85 - 97 , 31.03.2026
https://doi.org/10.15671/hjbc.1700698
https://izlik.org/JA62KG33WF

Abstract

Yakın Alan İletişimi (NFC), 13.56 MHz’de çalışan pilsiz bir arayüz olarak enerji hasadı ve veri aktarımını birleştirerek giyilebilir elektrokimyasal sensörlerde hızla benimsenmektedir. Bu derleme; anten/enerji hasadı, düşük güçlü potansiyostat/analog ön uç(AFE) ve akıllı telefon arayüzleri dâhil NFC-entegrasyon mimarilerini, glukoz, elektrolitler, pH ve stres hormonları gibi biyobelirteç uygulamaları üzerinden sistematik biçimde değerlendirir. Okuma mesafesi–güç bütçesi ödünleşimi, hareket artefaktları ve biyosıvılarda sürüklenme gibi başlıca sınırlamaları; devre ve malzeme düzeyindeki azaltma stratejileriyle birlikte özetler. Donanımın ötesinde, gürültü giderme, kalibrasyon ve gerçek zamanlı çıkarım için yapay zekâyı tartışır. Sağlık verisi mahremiyeti bağlamında NFC’ye özgü tehdit modelleri (dinleme, röle, taklit) ve karşı önlemleri (imzalı NDEF, erişim denetimi, post-kuantum kriptografi) değerlendirir. Ayrıca sürdürülebilirlik boyutunu; hafif ve geri dönüştürülebilir altlıklar, baskılı iletkenler ve enerji özerkliği perspektifinden ele alır. Sonuç olarak, güvenliğe duyarlı elektronik, yapay zeka destekli analiz ve sürdürülebilir üretimi bir araya getiren bir yol haritası sunarak pil gerektirmeyen NFC giyilebilir cihazların bakım noktası uygulamalarına (PoC) geçişini hızlandırmayı hedefler. 2021-2025 yılları arasında yayınlanan hakemli literatürün bu incelemesi, en son gelişmelere öncelik vermektedir.

Project Number

123C441

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The Future of NFC-Based Wearable Electrochemical Sensors: A Review Integrating Biomarker Tracking and Wireless Communication

Year 2026, Volume: 54 Issue: 2 , 85 - 97 , 31.03.2026
https://doi.org/10.15671/hjbc.1700698
https://izlik.org/JA62KG33WF

Abstract

Near Field Communication (NFC), a battery-free interface operating at 13.56 MHz and combining energy harvesting and data transmission, is rapidly being adopted in wearable electrochemical sensors. This review systematically evaluates NFC-integration architectures, including antenna/energy harvesting, low-power potentiostat/analog front-end (AFE), and smartphone interfaces, for applications with biomarkers such as glucose, electrolytes, pH, and stress hormones. It summarizes key limitations, such as read distance–power budget tradeoffs, motion artifacts, and drift in biofluids, along with mitigation strategies at the circuit and material levels. Beyond hardware, it discusses artificial intelligence for denoising, calibration, and real-time inference. It evaluates NFC-specific threat models (eavesdropping, relay, spoofing) and countermeasures (signed NDEF, access control, post-quantum cryptography) in the context of health data privacy. It also addresses the sustainability dimension from the perspective of lightweight and recyclable substrates, printed conductors, and energy autonomy. Ultimately, it aims to accelerate the migration of battery-free NFC wearables to point-of-care (PoC) applications by providing a roadmap that combines security-aware electronics, AI-powered analytics, and sustainable manufacturing. This review of the peer-reviewed literature published between 2021 and 2025 prioritises the most recent developments.

Ethical Statement

This manuscript is a literature review that synthesizes and analyzes findings from previously published studies; it does not involve any new experiments with human participants, animals, cell lines, unpublished data, or confidential patient information. Consequently, ethical approval and informed consent were not required. All sources used in this review are properly cited and publicly accessible. The author has adhered to high standards of academic integrity, avoided plagiarism, and accurately represented the findings of the works discussed. The author declares that they have no competing interests, financial or otherwise, that could have influenced the content or interpretation of this review. No funding body had any role in the design, collection, analysis, interpretation of data, or writing the manuscript.

Supporting Institution

Hasret Turkmen was supported by TUBİTAK (Scientific and Technological Research Council of TÜRKİYE) [No: 123C441].

Project Number

123C441

Thanks

The author would like to thank the editors and anonymous referees who provided insightful suggestions and comments to improve the quality of the review paper.

References

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  • S.S. Kwak, S. Yoo, R. Avila, H.U. Chung, H. Jeong, C. Liu, J.A. Rogers, Skin-integrated devices with soft, holey architectures for wireless physiological monitoring, with applications in the neonatal intensive care unit, Adv. Mater., 33 (2021) 2103974.
  • P. Escobedo, M.M. Erenas, Á. Martínez-Olmos, M.A. Carvajal, S. Gonzalez-Chocano, L.F. Capitán-Vallvey, A.J. Palma, General-purpose passive wireless point-of-care platform based on smartphone, Biosens. Bioelectron., 141 (2019) 111360.
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  • N.R. Stradiotto, H. Yamanaka, M.V.B. Zanoni, Electrochemical sensors: a powerful tool in analytical chemistry, J. Braz. Chem. Soc., 14 (2003) 159-173.
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  • P. Teengam, W. Siangproh, S. Tontisirin, A. Jiraseree-amornkun, N. Chuaypen, P. Tangkijvanich, O. Chailapakul, NFC-enabling smartphone-based portable amperometric immunosensor for hepatitis B virus detection, Sens. Actuators B Chem., 326 (2021) 128825.
  • K. Promsuwan, A. Soleh, K. Samoson, K. Saisahas, S. Wangchuk, J. Saichanapan, W. Limbut, Novel biosensor platform for glucose monitoring via smartphone based on battery-less NFC potentiostat, Talanta, 256 (2023) 124266.
  • H. Mirzajani, T. Abbasiasl, F. Mirlou, E. Istif, M.J. Bathaei, Ç. Dağ, L. Beker, An ultra-compact and wireless tag for battery-free sweat glucose monitoring, Biosens. Bioelectron., 213 (2022) 114450.
  • C. Li, Y. Liu, G. Liu, Q. Tan, X. Dou, Y. Xie, X. Zhang, Development of a low-cost flexible potentiometric detector and its integrated system for electrochemical sensing of electrolytes in human sweat, Sens. Actuators Rep., 8 (2025) 100286.
  • M. Ku, J. Kim, J.E. Won, W. Kang, Y.G. Park, J. Park, J.U. Park, Smart, soft contact lens for wireless immunosensing of cortisol, Sci. Adv., 6 (2020) eabb2891.
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There are 74 citations in total.

Details

Primary Language English
Subjects Sensor Technology, Electrochemistry
Journal Section Review
Authors

Hasret Turkmen 0000-0001-8419-7207

Project Number 123C441
Submission Date May 16, 2025
Acceptance Date February 4, 2026
Publication Date March 31, 2026
DOI https://doi.org/10.15671/hjbc.1700698
IZ https://izlik.org/JA62KG33WF
Published in Issue Year 2026 Volume: 54 Issue: 2

Cite

APA Turkmen, H. (2026). The Future of NFC-Based Wearable Electrochemical Sensors: A Review Integrating Biomarker Tracking and Wireless Communication. Hacettepe Journal of Biology and Chemistry, 54(2), 85-97. https://doi.org/10.15671/hjbc.1700698
AMA 1.Turkmen H. The Future of NFC-Based Wearable Electrochemical Sensors: A Review Integrating Biomarker Tracking and Wireless Communication. HJBC. 2026;54(2):85-97. doi:10.15671/hjbc.1700698
Chicago Turkmen, Hasret. 2026. “The Future of NFC-Based Wearable Electrochemical Sensors: A Review Integrating Biomarker Tracking and Wireless Communication”. Hacettepe Journal of Biology and Chemistry 54 (2): 85-97. https://doi.org/10.15671/hjbc.1700698.
EndNote Turkmen H (March 1, 2026) The Future of NFC-Based Wearable Electrochemical Sensors: A Review Integrating Biomarker Tracking and Wireless Communication. Hacettepe Journal of Biology and Chemistry 54 2 85–97.
IEEE [1]H. Turkmen, “The Future of NFC-Based Wearable Electrochemical Sensors: A Review Integrating Biomarker Tracking and Wireless Communication”, HJBC, vol. 54, no. 2, pp. 85–97, Mar. 2026, doi: 10.15671/hjbc.1700698.
ISNAD Turkmen, Hasret. “The Future of NFC-Based Wearable Electrochemical Sensors: A Review Integrating Biomarker Tracking and Wireless Communication”. Hacettepe Journal of Biology and Chemistry 54/2 (March 1, 2026): 85-97. https://doi.org/10.15671/hjbc.1700698.
JAMA 1.Turkmen H. The Future of NFC-Based Wearable Electrochemical Sensors: A Review Integrating Biomarker Tracking and Wireless Communication. HJBC. 2026;54:85–97.
MLA Turkmen, Hasret. “The Future of NFC-Based Wearable Electrochemical Sensors: A Review Integrating Biomarker Tracking and Wireless Communication”. Hacettepe Journal of Biology and Chemistry, vol. 54, no. 2, Mar. 2026, pp. 85-97, doi:10.15671/hjbc.1700698.
Vancouver 1.Hasret Turkmen. The Future of NFC-Based Wearable Electrochemical Sensors: A Review Integrating Biomarker Tracking and Wireless Communication. HJBC. 2026 Mar. 1;54(2):85-97. doi:10.15671/hjbc.1700698

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