Naproxen Derivative Interaction Properties with ct-DNA

Year 2019, Volume: 47 Issue: 2, 177 - 184, 18.09.2019

Nuriye Akbay , Zeynep Koksal , Tugba Taskin-tok , Ayse Uzgoren-baran

https://doi.org/10.15671/hjbc.517481

Cited By: 3

https://izlik.org/JA38AZ39LA

Abstract

Interaction mode of a naproxen derivative (NH) with ct-DNA was explored by absorption and fluorescence spectroscopy. The experimental results revealed the static quenching as a result of groove binding between the naproxen derivative and ct-DNA. Computational studies were carried out to deeper understanding of the interactions. Molecular docking calculations shown that the interaction between NH and ct-DNA is resulted by groove binding. In addition to spectral data, docking studies revealed that NH-A_DNA and NH-B_DNA complexes had different interaction and conformational trends to each DNA isomer.

Keywords

Quenching , Groove binding , Naproxen , Stern-Volmer

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