Practical synthesis of pyrido[1,2-a]benzimidazoles via multicomponent reactions

Abstract

Tek basamakta siklik enamin (2-(nitrometilen)-2,3-dihidro-1H-benzo[d]imidazol), malononitril ve aromatik aldehit ile çoklu bileşenli tepkime üzerinden 1-amino-3-(4-substitue)-4-nitro-3,5-dihidrobenzo[4,5]imidazo[1,2-a]piridin-2-karbonitril lerin kolay ve etkili bir biçimde sentezi açığa çıkarıldı. Ayrıca, istenilen ürünlerin eldesinde herhangi bir saflaştırma prosedürü gerektirmedi. Bütün ürünler saf olarak tepkime ortamında çökeltildi. On yeni yapı fiziksel ve spektroskopik yöntemler kullanılarak karakterize edildi (e.n., IR, NMR ve TOF-MS analizleri).

Keywords

• Heterocyclic ketene aminal,enamine,multicomponent,benzimidazole,pyridobenzimidazole

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