Conventional and Microwave Assisted Synthesis of New Triazole Derivatives and Evaluation of Their Antimicrobial Activities

Year 2019, Volume: 47 Issue: 3, 277 - 286, 23.10.2019

Zeynep Özdemir , İnci Selin Doğan Mehmet Abdullah Alagöz Hasan Erdinç Sellitepe , Didem Kart

https://doi.org/10.15671/hjbc.626966

https://izlik.org/JA67JJ87YR

Abstract

I
n this study, four new oxime ether derivatives were synthesized and their antimicrobial activities were evaluated. At the
same time, a comparison of the efficiency of the conventional method of synthesis with the microwave method was investigated. The structures of synthesized compounds were confirmed by their IR, 1H-NMR, and HRMS spectra. Antimicrobial
activity of the compounds was tested against two Gr (+) bacteria (S. aureus, E. faecalis), two Gr (-) bacteria (P. aeruginosa, E.
coli), and three yeast-like fungi (C. albicans, C. krusei, C. parapsilosis) by modified agar dilution method.

Keywords

Triazole , oxime ether , microwave synthesis , antimicrobial activity

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