Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats

Ayşegül Akbay Yarpuzlu; Yeşim Uğur; Ayşegül Nazikoğlu; Esin Asan; İlkay Yildiz

Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats

Abstract

Introduction2-Phenoxymethyl-5-chlorobenzimidazole is a substituted benzimidazole that has been synthesized by our team. Benzimidazoles and their substituted derivatives have been used as antimicrobials in the treatment of Pneumocystis pneumonia 1 , Helicobacter pylori 2 , in plant protection 3 , as antivirals against cytomegalovirus 4 , as well as antiparasitics against Giardia lamblia 5 and some Microsporidia species such as Encephalitozoon hellem and Encephalitozoon intestinalis 6 by binding to the cytoskeleton 7 . Some have also been shown to be inhibitors of HIV-RT 8 , and Adenosine Deaminase ADA 9

Keywords

AIDS,HIV-RT inhibitor,2-phenoxymethyl-5-chlorobenzimidazole,Kidney,rat,renal tubules,dimethylsulfoxide

References

1. Fishman JA. Treatment of Infection Due to Pneumocystis carini. Antimicrobial Agents and Chemotherapy. 1998; 42;6:1309-1314.
2. Hof H. Critical Annotations to the Use of Azole Antifungals for Plant Protection. Antimicrobial Agents Chemother. 2001; 45;11:2987-2990.
3. Chiba N, von Zanten SJ, Sinclair P, Ferguson RA, Escobedo S, Grace E. Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatment-Helicobacter pylori positive ( CADET-Hp) randomised controlled trial. BMJ 2002,324;7344:1012.
4. Buerger I, Reefschlaeger J, Bender W, Eckenberg P, Popp A, Weber O, Graeger S, Klenk HD, Ruebsamen,Waigmann H, Hallenberger S. A Novel Nonnucleoside Inhibitor Specifically Targets Cytomegalovirus DNA Maturation via the UL89 and UL56 Gene Products. J. Virol.2001,75;19:9077-9086.
5. Adam RD. Biology of Giardia lamblia. Clin Microbiol Rev. 2001,14;3:447-475.
6. Ridoux O, Drancourt M. In vitro Susceptibilies of the Microsporidia Encephalitozoon cuniculi, Encephalitozoon hellem and Encephalitozoon intestinalis to Albendozole and its sulfoxide and sulfone Metabolites. Antimicrob Agents Chemother. 1998,42 ;12: 3301-3303.
7. Morrissette NS. Sibley LD. Cytoskeleton to Amplicomplexon Parasites. Microbiol Mol Biol Rev. 2002,66;1:21-38.
8. Akbay A, Ören Ý, Temiz-Arpacý Ö, Aký-Þener E, Yalçýn Ý. Synthesis and HIV-1 Reverse transcriptase Inhibitor Activity of Some 2,5,6-Substituted Benzoxazole, Benzimidazole, Benzthiazole and Oxazolo (4,5-b) pyridine Derivatives. ArzneimForschDrugRes. 2003,53;4:266-71.

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Ayşegül Akbay Yarpuzlu This is me

Yeşim Uğur This is me

Ayşegül Nazikoğlu This is me

Esin Asan This is me

İlkay Yildiz This is me

Publication Date

January 1, 2007

Submission Date

-

Acceptance Date

-

Published in Issue

Year 2007 Volume: 35 Number: 1

IZ

https://izlik.org/JA76GL34RM

Cite

RIS / Bibtex

APA

Akbay Yarpuzlu, A., Uğur, Y., Nazikoğlu, A., Asan, E., & Yildiz, İ. (2007). Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats. Hacettepe Journal of Biology and Chemistry, 35(1), 25-30. https://izlik.org/JA76GL34RM

AMA

1.Akbay Yarpuzlu A, Uğur Y, Nazikoğlu A, Asan E, Yildiz İ. Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats. HJBC. 2007;35(1):25-30. https://izlik.org/JA76GL34RM

Chicago

Akbay Yarpuzlu, Ayşegül, Yeşim Uğur, Ayşegül Nazikoğlu, Esin Asan, and İlkay Yildiz. 2007. “Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-Phenoxymethyl-5-Chlorobenzimidazole Administration in Rats”. Hacettepe Journal of Biology and Chemistry 35 (1): 25-30. https://izlik.org/JA76GL34RM.

EndNote

Akbay Yarpuzlu A, Uğur Y, Nazikoğlu A, Asan E, Yildiz İ (January 1, 2007) Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats. Hacettepe Journal of Biology and Chemistry 35 1 25–30.

IEEE

[1]A. Akbay Yarpuzlu, Y. Uğur, A. Nazikoğlu, E. Asan, and İ. Yildiz, “Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats”, HJBC, vol. 35, no. 1, pp. 25–30, Jan. 2007, [Online]. Available: https://izlik.org/JA76GL34RM

ISNAD

Akbay Yarpuzlu, Ayşegül - Uğur, Yeşim - Nazikoğlu, Ayşegül - Asan, Esin - Yildiz, İlkay. “Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-Phenoxymethyl-5-Chlorobenzimidazole Administration in Rats”. Hacettepe Journal of Biology and Chemistry 35/1 (January 1, 2007): 25-30. https://izlik.org/JA76GL34RM.

JAMA

1.Akbay Yarpuzlu A, Uğur Y, Nazikoğlu A, Asan E, Yildiz İ. Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats. HJBC. 2007;35:25–30.

MLA

Akbay Yarpuzlu, Ayşegül, et al. “Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-Phenoxymethyl-5-Chlorobenzimidazole Administration in Rats”. Hacettepe Journal of Biology and Chemistry, vol. 35, no. 1, Jan. 2007, pp. 25-30, https://izlik.org/JA76GL34RM.

Vancouver

1.Ayşegül Akbay Yarpuzlu, Yeşim Uğur, Ayşegül Nazikoğlu, Esin Asan, İlkay Yildiz. Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats. HJBC [Internet]. 2007 Jan. 1;35(1):25-30. Available from: https://izlik.org/JA76GL34RM