Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly ethylene imine Macrocomplexes and DNA Conjugates

Zakir M.o. Rzayev; Dönsel Erdoğan; Mustafa Türk; Erhan Pişkin

Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly ethylene imine Macrocomplexes and DNA Conjugates

Abstract

New boron-containing graft copolymers and their poly ethylene imine PEI macrocomplexes were synthesized byamidolysis of poly N-isopropylacrylamide-co-maleic anhydride s [poly NIPA-co-MA s] with ethanolamine ester ofdiphenylboronic acid EAPB , and following complexation of graft copolymers with poly ethylene imine PEI ,respectively. The structure, compositions and properties stimuli-responsive, polyelectrolyte and thermal behavior ofsynthesized copolymers were characterized by FTIR,1H {13C} NMR and UV spectroscopy, viscometry, DSC and TGAanalyses. It was shown that under given conditions pH, temperature and grafting degree , these H-bondingmacrocomplexes with hydrophobic diphenylborate side chain groups in aqueous solutions undergo a reversiblecooperative conformational transition which is provided a promising possibility of adjusting the hydophobic–hydrophilicbalance in the studied graft copolymer systems. Fluorescence measurements indicated that poly[ NIPA-co-MA -gEAPB]/PEI macrocomplex easily transferred to the HELA tumor cells, and showed low cytotoxicity against a normalcell line. Obtained results, especially stimuli-responsive and very high transferable behavior allow use these boroncontaining graft copolymer systems as non-viral vectors in gene- and bioengineering processes and drug deliverysystems, as well as in boron neutron capture therapy

Keywords

boron-containing graft copolymers,poly ethylene imine,stimuli-responsivity,DNA conjugates

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Zakir M.o. Rzayev This is me

Dönsel Erdoğan This is me

Mustafa Türk This is me

Erhan Pişkin This is me

Publication Date

April 1, 2008

Submission Date

-

Acceptance Date

-

Published in Issue

Year 2008 Volume: 36 Number: 2

IZ

https://izlik.org/JA28HF77AP

Cite

RIS / Bibtex

APA

Rzayev, Z. M., Erdoğan, D., Türk, M., & Pişkin, E. (2008). Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly ethylene imine Macrocomplexes and DNA Conjugates. Hacettepe Journal of Biology and Chemistry, 36(2), 83-98. https://izlik.org/JA28HF77AP

AMA

1.Rzayev ZM, Erdoğan D, Türk M, Pişkin E. Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly ethylene imine Macrocomplexes and DNA Conjugates. HJBC. 2008;36(2):83-98. https://izlik.org/JA28HF77AP

Chicago

Rzayev, Zakir M.o., Dönsel Erdoğan, Mustafa Türk, and Erhan Pişkin. 2008. “Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly Ethylene Imine Macrocomplexes and DNA Conjugates”. Hacettepe Journal of Biology and Chemistry 36 (2): 83-98. https://izlik.org/JA28HF77AP.

EndNote

Rzayev ZM, Erdoğan D, Türk M, Pişkin E (April 1, 2008) Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly ethylene imine Macrocomplexes and DNA Conjugates. Hacettepe Journal of Biology and Chemistry 36 2 83–98.

IEEE

[1]Z. M. Rzayev, D. Erdoğan, M. Türk, and E. Pişkin, “Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly ethylene imine Macrocomplexes and DNA Conjugates”, HJBC, vol. 36, no. 2, pp. 83–98, Apr. 2008, [Online]. Available: https://izlik.org/JA28HF77AP

ISNAD

Rzayev, Zakir M.o. - Erdoğan, Dönsel - Türk, Mustafa - Pişkin, Erhan. “Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly Ethylene Imine Macrocomplexes and DNA Conjugates”. Hacettepe Journal of Biology and Chemistry 36/2 (April 1, 2008): 83-98. https://izlik.org/JA28HF77AP.

JAMA

1.Rzayev ZM, Erdoğan D, Türk M, Pişkin E. Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly ethylene imine Macrocomplexes and DNA Conjugates. HJBC. 2008;36:83–98.

MLA

Rzayev, Zakir M.o., et al. “Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly Ethylene Imine Macrocomplexes and DNA Conjugates”. Hacettepe Journal of Biology and Chemistry, vol. 36, no. 2, Apr. 2008, pp. 83-98, https://izlik.org/JA28HF77AP.

Vancouver

1.Zakir M.o. Rzayev, Dönsel Erdoğan, Mustafa Türk, Erhan Pişkin. Bioengineering Functional Copolymers. VIII. Stimuli-Responsive Boron-Containing Graft Copolymers and Their Poly ethylene imine Macrocomplexes and DNA Conjugates. HJBC [Internet]. 2008 Apr. 1;36(2):83-98. Available from: https://izlik.org/JA28HF77AP