Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma

Seçil Utku; Erkut Yılmaz; Deniz Türkmen; Lokman Uzun; Bora Garipcan; Rıdvan Say; Adil Denizli

Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma

Abstract

Thermosensitive gels have attracted a great deal of attention for the applications of drug delivery systems, actuators,separation and removal of biological compounds and metals. Poly N-isopropylacrylamide poly NIPA , arepresentative gel, has a lower critical solution temperature LCST in the vicinity of 32°C i.e. showing hydrophilicityand hydrophobicity in water at lower and higher temperatures, respectively. Novel adsorbents using thermosensitivegels for trapping metals were reported where poly NIPA was used as a thermosensitive backbone polymer. Achelating group, which interacts with heavy metals, was introduced into poly NIPA with a molecular imprintingtechnique using a specific metal as the template. Although it is emphasized that metals play important roles inbiological processes and some of them are classified as essential, the toxic symptoms will manifest when a metal ionlevel exceeds a certain threshold level. Many symptoms of iron toxicity, for example heart attacks, diabetes, arthritis,depression and liver failure, are arised from the absorption of iron in unacceptably high concentrations because of agenetic failure or by accidental ingestion.The aim of this study is to prepare ion-imprinted polymersfor the removalof iron from aqueous solutions andsolutionsthalassemia patient`s plasma.N-methacryloyl- L -cysteine MAC wasselected as the metal complexing monomer, with the goal preparing a solid-phase which has a high selectivity for Fe3+ions. Poly NIPA was used as a thermosensitive backbone polymer matrix. A chelating group [N-methacryloyl- L cysteine MAC ] which interacts with Fe3+ions, was introduced into poly NIPA with a molecular imprinting technique.After removal of the Fe3+ions, adsorption of Fe3+ions from thalassemia patient’s plasma both on the poly NIPA-MAC and Fe3+-imprinted poly NIPA-MAC particles were studied in batch-wise

Keywords

thermosensitive polymers,poly NIPA,Ion imprinting,Thalassemia,Affinity binding

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Seçil Utku This is me

Erkut Yılmaz This is me

Deniz Türkmen This is me

Lokman Uzun This is me

Bora Garipcan This is me

Rıdvan Say This is me

Adil Denizli This is me

Publication Date

December 1, 2008

Submission Date

-

Acceptance Date

-

Published in Issue

Year 2008 Volume: 36 Number: 4

IZ

https://izlik.org/JA53DW84XT

Cite

RIS / Bibtex

APA

Utku, S., Yılmaz, E., Türkmen, D., Uzun, L., Garipcan, B., Say, R., & Denizli, A. (2008). Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma. Hacettepe Journal of Biology and Chemistry, 36(4), 291-304. https://izlik.org/JA53DW84XT

AMA

1.Utku S, Yılmaz E, Türkmen D, et al. Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma. HJBC. 2008;36(4):291-304. https://izlik.org/JA53DW84XT

Chicago

Utku, Seçil, Erkut Yılmaz, Deniz Türkmen, et al. 2008. “Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma”. Hacettepe Journal of Biology and Chemistry 36 (4): 291-304. https://izlik.org/JA53DW84XT.

EndNote

Utku S, Yılmaz E, Türkmen D, Uzun L, Garipcan B, Say R, Denizli A (December 1, 2008) Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma. Hacettepe Journal of Biology and Chemistry 36 4 291–304.

IEEE

[1]S. Utku et al., “Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma”, HJBC, vol. 36, no. 4, pp. 291–304, Dec. 2008, [Online]. Available: https://izlik.org/JA53DW84XT

ISNAD

Utku, Seçil - Yılmaz, Erkut - Türkmen, Deniz - Uzun, Lokman - Garipcan, Bora - Say, Rıdvan - Denizli, Adil. “Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma”. Hacettepe Journal of Biology and Chemistry 36/4 (December 1, 2008): 291-304. https://izlik.org/JA53DW84XT.

JAMA

1.Utku S, Yılmaz E, Türkmen D, Uzun L, Garipcan B, Say R, Denizli A. Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma. HJBC. 2008;36:291–304.

MLA

Utku, Seçil, et al. “Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma”. Hacettepe Journal of Biology and Chemistry, vol. 36, no. 4, Dec. 2008, pp. 291-04, https://izlik.org/JA53DW84XT.

Vancouver

1.Seçil Utku, Erkut Yılmaz, Deniz Türkmen, Lokman Uzun, Bora Garipcan, Rıdvan Say, Adil Denizli. Ion-Imprinted Thermosensitive Polymers for Fe3+ Removal from Human Plasma. HJBC [Internet]. 2008 Dec. 1;36(4):291-304. Available from: https://izlik.org/JA53DW84XT