The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis elegans Lifespan

Abdullah Olgun; Zeynep Köksal; Abdulkadir Çoban

The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis elegans Lifespan

Abstract

Endoplasmic reticulum ER stress is involved in many diseases including diabetes, cancer and aging. Tauroursodeoxycholic acid TUDCA is a chemical chaperone that reduces ER stress. Caenorhabditis elegans C. elegans , a widely used model organism in aging studies, also suffers from ER stress. In this study, we tested the effect of TUDCA on C. elegans life span with the aim to decipher the contribution of ER stress on C. elegans aging. We tested TUDCA at the concentrations of 0.625, 1.25, 2.5, 3.75, 5, 7.5, 10, 15 and 20 mM. It showed a negative effect on the life span at all of the tested concentrations except 3.75 mM. At this concentration it had no toxicity nor an effect on longevity. One of the previously reported critical micellar concentrations CMC of TUDCA is closer to this concentration. Therefore TUDCA’s mechanism of action could be explained, at least in part, by its micelle formation. It could have exerted negative effects at both lower and higher concentrations than CMC. If it had a positive effect on life span through ameliorating ER stress at the CMC, this could have been neutralized by its partial toxicity. Our results can be helpful in future studies on TUDCA which is a very important and promising therapeutical agent.

Keywords

Endoplasmic reticulum stress,Tauroursodeoxycholic acid,Caenorhabditis elegans,Aging

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Abdullah Olgun This is me

Zeynep Köksal This is me

Abdulkadir Çoban This is me

Publication Date

December 1, 2010

Submission Date

-

Acceptance Date

-

Published in Issue

Year 2010 Volume: 38 Number: 4

IZ

https://izlik.org/JA94ZF79WB

Cite

RIS / Bibtex

APA

Olgun, A., Köksal, Z., & Çoban, A. (2010). The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis elegans Lifespan. Hacettepe Journal of Biology and Chemistry, 38(4), 287-290. https://izlik.org/JA94ZF79WB

AMA

1.Olgun A, Köksal Z, Çoban A. The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis elegans Lifespan. HJBC. 2010;38(4):287-290. https://izlik.org/JA94ZF79WB

Chicago

Olgun, Abdullah, Zeynep Köksal, and Abdulkadir Çoban. 2010. “The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis Elegans Lifespan”. Hacettepe Journal of Biology and Chemistry 38 (4): 287-90. https://izlik.org/JA94ZF79WB.

EndNote

Olgun A, Köksal Z, Çoban A (December 1, 2010) The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis elegans Lifespan. Hacettepe Journal of Biology and Chemistry 38 4 287–290.

IEEE

[1]A. Olgun, Z. Köksal, and A. Çoban, “The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis elegans Lifespan”, HJBC, vol. 38, no. 4, pp. 287–290, Dec. 2010, [Online]. Available: https://izlik.org/JA94ZF79WB

ISNAD

Olgun, Abdullah - Köksal, Zeynep - Çoban, Abdulkadir. “The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis Elegans Lifespan”. Hacettepe Journal of Biology and Chemistry 38/4 (December 1, 2010): 287-290. https://izlik.org/JA94ZF79WB.

JAMA

1.Olgun A, Köksal Z, Çoban A. The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis elegans Lifespan. HJBC. 2010;38:287–290.

MLA

Olgun, Abdullah, et al. “The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis Elegans Lifespan”. Hacettepe Journal of Biology and Chemistry, vol. 38, no. 4, Dec. 2010, pp. 287-90, https://izlik.org/JA94ZF79WB.

Vancouver

1.Abdullah Olgun, Zeynep Köksal, Abdulkadir Çoban. The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis elegans Lifespan. HJBC [Internet]. 2010 Dec. 1;38(4):287-90. Available from: https://izlik.org/JA94ZF79WB