Gebelik Süresince Uygulanan Oktilfenolün Sıçanlarda İnfantisidal Davranış Üzerindeki Etkileri

Abstract

İnfantisit, sıçanların da dahil olduğu bir çok hayvan türünde gözlenmiştir. Bu çalışmada, 4-tert-oktilfenole OP gebelik döneminde maruz kalmanın erkek ve dişi yavru sıçanlar üzerindeki davranışsal etkileri araştırılmıştır. Gebe sıçanlar, gebeliğin 1-20. günleri süresince 100 mg/kg/gün OP100 ve 250 mg/kg/gün OP250 olmak üzere oktilfenole maruz bırakılmış, kontrol ve yağ kontrol olarak gruplanmıştır. Doğum sonrasında infantisidal davranış OP100 ve OP250 uygulama gruplarında gözlenmiştir. Yavru sıçanlar, OP100 grubunda %47 oranında ve OP250 grubunda %53 oranında yenerek öldürülmüştür. Bu çalışmanın sonuçları, fötal dönemde uygulanan oktilfenolün sıçanlarda olumsuz etkilere neden olduğunu ortaya koymaktadır

Keywords

• Çevresel östrojenler,oktilfenol,infantisit,sıçan

Effects of 4-tert-Octylphenol, during Pregnancy Period, on Infanticidal Behavior in Rats

Abstract

Infanticide has been observed in numerous animal species, including rats. The present study was carried out to investigate the behavioral effects of 4-tert-Octylphenol OP exposure at fetal period on male and female rat offsprings. Pregnant rats were treated with OP 100 or 250 mg/kg/day in vehicle corn oil or vehicle alone daily from day 1 to day 20 of pregnancy. After birth, infanticidal behavior was observed in 100 mg/kg/ day OP100 and 250 mg/kg/day treatment group OP250 . 47% of live offspring were killed and consumed in OP100 and 53% of live offspring were killed and consumed in OP250. The results of this study suggest that, the octylphenol which was applied in fetal period causes negative effects on the rats.

Keywords

• Environmental estrogens,octylphenol,infanticide,rat

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