Synthesis and Characterization of Poly N- isopropylacrylamide Thermosensitive Based Cryogel

Abstract

The aim of this study was to reveal the changes in the nanostructure of the thermo-sensitive poly N- isopropylacrylamide-N methacryloyl- L -histidine [poly NIPA-MAH ] monolithic cryogel with changing temperature around lower critical solution temperature LCST of NIPA. Poly NIPA-MAH cryogel was prepared by free radical cryopolymerization of NIPA with MAH as a functional comonomer and N,N-methylene- bisacrylamide MBAAm as crosslinker directly in a plastic syringe. Cryo-polymerization was initiated by N,N,N,N-tetramethylene diamine TEMED and ammonium persulfate APS pair at subzero temperature -16ºC in an ice bath. LCST of poly NIPA-MAH cryogel was found to be 34ºC. The surface morphology and bulk structure of poly NIPA-MAH cryogel was revealed with scanning electron microscopy SEM . Poly NIPA- MAH cryogel with 60–100 μm pore diameter has a specific surface area of 42.6 m2/g polymer. Poly NIPA- MAH cryogel was characterized by Fourier transform infrared spectrometer FTIR and swelling test. The equilibrium swelling degree of poly NIPA-MAH cryogel was 22.08 g H2O/g for dry cryogel. The presence of NIPA makes cryogel morpholgy highly porous and differentiates it from conventional gels.

Keywords

• N-isopropylacrylamide NIPA,thermosensitive polymers,cryogels,histidine

Poli N-izopropilakrilamid bazlı kriyojelin sentez ve karakterizasyonu

Abstract

B u çalışmanın amacı NIPA’nın düşük kritik çözelti sıcaklığı LCST civarındaki sıcaklık değişimlerine karşı pH’ya ve sıcaklığa duyarlı poli N-izopropilakrilamid-N metakriloil- L -histidin [poli NIPA-MAH ] monolitik kriyojelin nanoyapısındaki değişimleri açıklamaktır. Poli NIPA-MAH kriyojel plastik şırınga içerisinde NIPA’nın fonksiyonel komonomer olarak kullanılan MAH ile serbest radikal kriyokopolimerizasyonu ile hazırlanmış olup N,N-metilen-bisakrilamid MBAAm çapraz bağlayıcı olarak kullanıldı. Kriyopolimerizasyon N,N,N,Ntetrametilen diamin TEMED ve amonyum persülfat APS çifti ile buz banyosunda sıfırın altındaki sıcaklıkta -16ºC başlatıldı. Poli NIPA-MAH kriyojelin LCST değeri 34ºC olarak bulundu. Poli NIPA-MAH kriyojelin yüzey morfolojisi ve yığın yapısı taramalı elektron mikroskobu SEM ile belirlenmiştir. 60–100 µm por çapına sahip poli NIPA-MAH kriyojel 42.6 m2/g polimer değerinde yüzey alanına sahiptir. Poli NIPA-MAH kriyojel Fourier dönüşümlü kızılötesi spektrometre FTIR ve şişme testi ile karakterize edildi. Kuru kriyojelin denge şişme derecesi 22.08 g HO/g olarak bulundu. Geleneksel jellerle karşılaştrıldığında, bu gözenekli kriyojel şekli NIPA’ya hızlı yanıt verme olanağı sağlar

Keywords

• N-izopropilakrilamid NIPA,sıcaklığa duyarlı polimerler,kriyojeller,histidin

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