Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen

Nazlı Sökmen; Seda Uysal; Fatma Ayhan; Mine Özyazıcı; Hakan Ayhan

Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen

Abstract

In this study, poly ethylene glycol-diacrylate PEG-DA hydrogels with two different concentrations, 30% and 50% w/w, were prepared by free radical polymerization method. Ethylene glycol dimethacrylate EGDMA and 2,2-dimethoxy-2-phenyl-acetophenone DMPA were used as cross-linking agent and photoinitiator, respectively. The model drug ketoprofen KP was incorporated into the hydrogel during photopolymerization and its release kinetics was tested spectrophotometrically at 256 nm in different buffer solutions of pH 7.5, 4.5, and 1.2. The results showed that the release of KP strongly depends on the dissolution of drug, initial polymer concentration, and the pH of the release medium. All of the obtained results were evaluated kinetically by first order and zero order, Higuchi and Hixon-Crowell kinetic models. The release mechanism was found to obey Higuchi and first order kinetics when the release data of the formulations were applied to the models in the different pH mediums.

Keywords

Hydrogel,Drug delivery,PEG-DA,Photopolymerization,Ketoprofen,Drug release models

References

1. Yu, H., Xiao, C., Synthesis and properties of novel hydrojels from oxidized konjac glucomannan crosslinked gelatin for in vitro drug delivery, Carbohydrate Polym., 72, 479-489, 2008.
2. Scott, R.A., Peppas, N.A., Highly crosslinked, PEGcontaining copolymers for sustained solute delivery, Biomater., 20:1371-1380, 1999.
3. Peppas, N.A., Bures, P., Leobandung, W., Ichikawa, H., Hydrogels in pharmaceutical formulations, Eur. J. Pharm. Biopharm., 50: 27–46, 2000.
4. Mellott, M.B., Searcy, K., Pishko, M.V., Release of protein from highly cross-linked hydrogels of poly(ethylene glycol) diacrylate fabricated by UV polymerization, Biomater., 22:929–941, 2001.
5. Gursel, I., Balcik, C., Arica, Y., Akkus, O., Akkas, N., and Hasirci, V., Synthesis and mechanical properties of interpenetrating networks of polyhydroxybutyrate-cohydroxyvalerate and polyhydroxyethyl methacrylate, Biomat., 19:1137-1143, 1998.
6. Choi, Hoo-K., Chun, Myung-K., Lee, S.H., Jang, M.H., Kim, H.D., Jung, C.S., Oh, S.Y., In vitro and in vivo study of poly(ethylene glycol) conjugated ketoprofen to extend the duration of action, Int. J. Pharm., 341; 50-57, 2007.
7. Vueba, M.L., Batista de Carvalho, L.A.E., Veiga, F., Sousa, J.J., Pina, M.E., Influence of cellulose ether polymers on ketoprofen release term from hydrophilic matrix tablets, Eur. J. Pharm. Biopharm., 58: 51-59, 2004.
8. Reynolds, J.E.F. (Ed.) Martindale The Extra Pharmacopeia, Vol.29, The Pharmaceutical Press, London, pp.25, 1989.

9. Liversidge, G.G. in: Florey K. (Ed.), Analytical Profiles of Drug Substance, Academic Press, Inc, New York, pp. 443-471, 1981.
10. Habib, M.J., Mesue, R., Development of Controlled Release Formulations of Ketoprofen for Oral Use, Drug Develop. Ind. Pharm., 21: 1463-1472, 1995.
11. Babazadeh, M., Design, synthesis and in vitro evaluation of vinyl ether type polymeric prodrugs of ibuprofen, ketoprofen and naproxen, Int. J. Pharm., 356: 167-173, 2008.
12. Jeong, B., Bae, Y.H., Kim, S.W., Drug Release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers, J. Control. Release, 63; 155-163, 2000.
13. El-Kenawy, R., Abdel-Hay, F.I., El-Newehy, M.H., Wnek., G.E., Processing of polymer nanofibers through electrospinning as drug delivery systems, Mater. Chem. Phys., 113; 296-302, 2009.
14. The United States Pharmacopeia, The National Formulary, USP XXIV, NF XIX, Supplement Two, Convention Inc., Rockville, 2000.
15. British Pharmacopeia (2005), Vol. I-II, The Stationery Office, London.
16. Clarke’s, Isolation and Identification of Drugs, 2nd Edition, Ed. A.C. Moffat, London: The Pharmaceutical Press, pp.697-698, 1986.
17. The United States Pharmacopeia, The National Formulary, USP XXIV, NF XIX, Supplement Two, Convention Inc., Rockville, 2000.
18. Ege, M.A., Karasulu, H.Y., Karasulu, E., Ertan, G., 4th Central European Symposium on Pharmaceutical Technology, 23–25 September, Vienna, 2001, Sci. Pharm. 69 (3), .
19. Martin, A., Physical Pharmacy, Physical Chemical Principles In The Pharmaceutical Sciences, Fourth Edition, Lea and Febiger, Philadelphia, Pennsylvania, USA 1993, pp. 324-361.
20. Borodkin, S., Tucker, F.E., Drug release from hydroxpropyl cellulose-polyvinyl acetate films, J. Pharm. Sci., 63: 1359-1363, 1974.
21. Higuchi, T., Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J. Pharm. Sci. 52: 1145-1149, 1963.
22. Schwartz, B.J., Simonelli, A.P., Higuchi, W.I., Drug release from wax matrices I; Analysis of data with firstorder kinetics and with the diffusion-controlled model, J. Pharm. Sci. 57: 274-277, 1968.
23. Wagner, J.G., Interpretation of percent dissolved time plots derived from in vitro testing of conventional tablets and capsules, J. Pharm. Sci., 58: 1253-1257, 1969.
24. Arida, A.I., Al-Tabakha, M.M., Encapsulation of ketoprofen for controlled drug release, Eur. J. Pharm. Biopharm., 66; 48-54, 2007.
25. Ayhan F., Özkan S., Gentamicin Release from Photopolymerized PEG Diacrylate and PHEMA Hydrogel Discs and Their in vitro Antimicrobial Activities, Drug Delivery, 14: 433-439, 2007.
26. Schwartz, B.J., Simonelli, A.P., Higuchi, W.I., Drug release from wax matrices I: Analysis of data with firstorder kinetics and with the diffusion-controlled model, J. Pharm. Sci. 57: 274-277, 1968.

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Nazlı Sökmen This is me

Seda Uysal This is me

Fatma Ayhan This is me

Mine Özyazıcı This is me

Hakan Ayhan This is me

Publication Date

December 1, 2009

Submission Date

-

Acceptance Date

-

Published in Issue

Year 2009 Volume: 37 Number: 4

IZ

https://izlik.org/JA35BG34NT

Cite

RIS / Bibtex

APA

Sökmen, N., Uysal, S., Ayhan, F., Özyazıcı, M., & Ayhan, H. (2009). Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen. Hacettepe Journal of Biology and Chemistry, 37(4), 337-343. https://izlik.org/JA35BG34NT

AMA

1.Sökmen N, Uysal S, Ayhan F, Özyazıcı M, Ayhan H. Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen. HJBC. 2009;37(4):337-343. https://izlik.org/JA35BG34NT

Chicago

Sökmen, Nazlı, Seda Uysal, Fatma Ayhan, Mine Özyazıcı, and Hakan Ayhan. 2009. “Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen”. Hacettepe Journal of Biology and Chemistry 37 (4): 337-43. https://izlik.org/JA35BG34NT.

EndNote

Sökmen N, Uysal S, Ayhan F, Özyazıcı M, Ayhan H (December 1, 2009) Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen. Hacettepe Journal of Biology and Chemistry 37 4 337–343.

IEEE

[1]N. Sökmen, S. Uysal, F. Ayhan, M. Özyazıcı, and H. Ayhan, “Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen”, HJBC, vol. 37, no. 4, pp. 337–343, Dec. 2009, [Online]. Available: https://izlik.org/JA35BG34NT

ISNAD

Sökmen, Nazlı - Uysal, Seda - Ayhan, Fatma - Özyazıcı, Mine - Ayhan, Hakan. “Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen”. Hacettepe Journal of Biology and Chemistry 37/4 (December 1, 2009): 337-343. https://izlik.org/JA35BG34NT.

JAMA

1.Sökmen N, Uysal S, Ayhan F, Özyazıcı M, Ayhan H. Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen. HJBC. 2009;37:337–343.

MLA

Sökmen, Nazlı, et al. “Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen”. Hacettepe Journal of Biology and Chemistry, vol. 37, no. 4, Dec. 2009, pp. 337-43, https://izlik.org/JA35BG34NT.

Vancouver

1.Nazlı Sökmen, Seda Uysal, Fatma Ayhan, Mine Özyazıcı, Hakan Ayhan. Photopolymerized Poly Ethylene Glycol Diacrylate Hydrogels for Controlled Release of Ketoprofen. HJBC [Internet]. 2009 Dec. 1;37(4):337-43. Available from: https://izlik.org/JA35BG34NT