Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats

M. Nalan Tüzmen; Mehmet Sezgin

Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats

Abstract

Metal plays an important role in neural toxicity. The changes of some essential metal levels are important in increasing oxidative stress and enhancing neurodegenerative disorders. The objective of this study was to determine the effect of light and dark treatment on the level of some essential elements such as Al, Fe, Zn and Cu and lipid peroxidation and the relationship between aging and changes in the level of these elements. Animals were divided into three groups: 24 h dark throughout the study highest melatonin release , 24 h light exposure light-induced functional pinealectomy and 12 h light/12 h dark exposure control group . Thereafter, each group was divided into two groups as young and old animals. All groups had access to food and water ad libitum for four weeks. After this period, lipid peroxidation end product, malondialdehyde MDA , and Al, Fe, Zn and Cu concentrations were measured in blood and brain tissue as well as hippocampus tissue. According to our findings MDA increased especially in dark groups of hippocampus tissue. It can be an indicator of increased free radical formation related to Al influenced light-dark treatment.

Keywords

Aging,Brain,Hippocampus,Oxidative stress,Essential elements

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

M. Nalan Tüzmen This is me

Mehmet Sezgin This is me

Publication Date

December 1, 2009

Submission Date

-

Acceptance Date

-

Published in Issue

Year 2009 Volume: 37 Number: 4

IZ

https://izlik.org/JA74GD97TF

Cite

RIS / Bibtex

APA

Tüzmen, M. N., & Sezgin, M. (2009). Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats. Hacettepe Journal of Biology and Chemistry, 37(4), 345-352. https://izlik.org/JA74GD97TF

AMA

1.Tüzmen MN, Sezgin M. Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats. HJBC. 2009;37(4):345-352. https://izlik.org/JA74GD97TF

Chicago

Tüzmen, M. Nalan, and Mehmet Sezgin. 2009. “Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats”. Hacettepe Journal of Biology and Chemistry 37 (4): 345-52. https://izlik.org/JA74GD97TF.

EndNote

Tüzmen MN, Sezgin M (December 1, 2009) Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats. Hacettepe Journal of Biology and Chemistry 37 4 345–352.

IEEE

[1]M. N. Tüzmen and M. Sezgin, “Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats”, HJBC, vol. 37, no. 4, pp. 345–352, Dec. 2009, [Online]. Available: https://izlik.org/JA74GD97TF

ISNAD

Tüzmen, M. Nalan - Sezgin, Mehmet. “Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats”. Hacettepe Journal of Biology and Chemistry 37/4 (December 1, 2009): 345-352. https://izlik.org/JA74GD97TF.

JAMA

1.Tüzmen MN, Sezgin M. Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats. HJBC. 2009;37:345–352.

MLA

Tüzmen, M. Nalan, and Mehmet Sezgin. “Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats”. Hacettepe Journal of Biology and Chemistry, vol. 37, no. 4, Dec. 2009, pp. 345-52, https://izlik.org/JA74GD97TF.

Vancouver

1.M. Nalan Tüzmen, Mehmet Sezgin. Alterations of Trace Elements and Malondialdehyde Levels in Blood, Brain and Hippocampus Following Functional Pinealectomy in Rats. HJBC [Internet]. 2009 Dec. 1;37(4):345-52. Available from: https://izlik.org/JA74GD97TF