Development of MIP-based QCM Sensors for Determination of Hyaluronic Acid (HA)

Year 2018, Volume: 46 Issue: 2, 273 - 283, 03.06.2018

Sibel Emir-diltemiz

Abstract

I
n this study, quartz crystal microbalance (QCM) based recognition systems have been developed for the
determination of hyaluronic acid (HA). For this purpose, firstly; N-methacryloyl-l-tyrosine (MAT), MAT-DGlucuronic
acid (MAT-D-GA) and MAT-Cu(II)-D-Glucuronic acid (MAT-Cu(II)-D-GA) pre-organized monomers
have been synthesized, and characterized. Then, D-glucuronic acid active sites of HA biomacromolecule
have been imprinted on QCM sensor surface to create HA selective binding sites. In the last step, the binding
interactions, usabilities in recognition and determination of prepared sensors have been investigated. 

Keywords

Hyaluronic acid, MIP-QCM, mıp, quartz crystal microbalance, molecularly ımprinted polymers

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