Functional Polysaccharides Blended Collagen Cryogels

Year 2018, Volume: 46 Issue: 1, 113 - 120, 01.03.2018

Sedat Odabaş

Abstract

Researches investigate new types of scaffolds for tissue engineering and regenerative medicine applications
to support cell proliferation and growth as well as tissue repair and regeneration. Although, there are
several types of polymeric materials and various kinds of preparation techniques are already used today;
there is still no consensus on the answer of the question “what is the best scaffold for tissue repair and
regeneration?”. Cryogels, which is a kind of hydrogels and, cryogelation, which is the technique for cryogel
preparation, are rather new for tissue engineering applications. Here in this study, dextran and carboxymethyl
cellulose functional polysaccharides blended collagen cryogels were prepared and characterized by chemical,
structural and biological evaluations. Results show that, these collagen cryogels with their polysaccharides
functional components have proper chemical and thermal characteristics and show good bio and hemocompatibility.
Therefore, these cryogels can be used as a candidate scaffold for tissue engineering and
regenerative medicine applications.

Keywords

Collagen, polysaccharides, cryogels, tissue engineering

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