Osteomyelitis is a bone infection caused by
microorganisms. Localized efficient drug delivery for treatment osteomyelitis
is an important topic. Amoxicillin is one the antibiotics used for
osteomyelitis therapy. Magnetic nanoparticles could achieve localized targeted
treatment with the help of magnetic field. Starch is biodegradable and
biocompatible biopolymer and can be used for carrier material for drug delivery.
The aim of this study is to develope amoxicillin loaded magnetic nanoparticles
for the use of treatment of osteomyelitis. Here, magnetite nanostructures were
coated with starch and characterized with FTIR, TGA and SEM. It was seen that
nanoparticles were spherical and had a size of 14-36 nm. Amoxicillin loading
onto magnetic nanoparticles was performed by adsorption method using various
concentrations of drug and 0.483 mg amoxicillin was adsorbed on per mg of
nanoparticles. In addition, in vitro
drug release at pH 7.4 was obtained as in a controlled manner. As a conclusion,
it can be suggested that amoxicillin loaded these nanoparticles could have a
potential for drug delivery to osteomyelitis.
Primary Language | English |
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Subjects | Engineering |
Journal Section | Articles |
Authors | |
Publication Date | April 19, 2020 |
Acceptance Date | April 18, 2020 |
Published in Issue | Year 2020 Volume: 48 Issue: 2 |
HACETTEPE JOURNAL OF BIOLOGY AND CHEMİSTRY
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