A Retrospective Study on Urinary Tract Infection Agents Isolated from Children and Their Antibiotic Susceptibility

Year 2020, Volume: 48 Issue: 3, 265 - 274, 15.06.2020

Neslihan İdil Esra Deniz Candan Abbas Yousefi Rad

https://doi.org/10.15671/hjbc.639411

Cited By: 4

Abstract

Antibiotics are important premises in the treatment of
urinary tract infection (UTI). However, the use of antibiotics is an important
risk factor causing antibiotic resistance. Antibiotic inappropriate resistance is one of the most important problems of
increased uropathogenic resistance,
especially in pediatric urology. Deficiencies in empirical prescription
practices can make this problem even worse. In this study, the demographic
characteristics of pediatric patients, UTI agents, and antibiotic resistance
resistance of these agents were retrospectively evaluated by an automated
system. The data from 719 UTI agents isolated from children were separately
analyzed for four different age groups (0-2, 2-6, 6-12, and 12-17). The most
commonly isolated infection agents were Escherichia
coli (68.01%), Klebsiella pneumoniae (19.75%), Klebsiella oxytoca (3.34%), Enterobacter cloacae (2.23%), and Pseudomonas aeruginosa
(1.95%). Among the age groups, 0-2 age
group was quite diverse in terms of infection
agents and antibiotic resistance values of these agents were significantly high
in this group (p<0.05). Regarding the antibiotic resistance, the most
noteworthy ones were the resistance against ampicillin (70.2%), amoxicillin-clavulanate (49.0%), cefixime
(38.2%), and trimethoprim/sulfamethoxazole
(37.1%). Our study indicated that
children in 0-2 age group were under
higher risk in terms of UTI agents and their antibiotic resistance but this
risk was reduced with increasing age. Moreover, the ratio of girls with UTI was
greater than that of boys within 0-2 age group. There was high resistance
against cephalosporin, ampicillin, amoxicillin-clavulanate, and trimethoprim/sulfamethoxazole, whereas the resistance
against carbapenem (imipenem, ertapenem and meropenem) was found to be low and
there was no significant increase.

Keywords

Antibiotic resistance, Escherichia coli, Pediatric urology, Urinary tract infection.

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