Year 2021, Volume 49 , Issue 1, Pages 69 - 78 2021-01-01

It is known that free radicals, their products and reactive oxygen species (ROS) are associated with many diseases. The study focuses on both some changes in oxidative stress factors in patients with acute appendicitis (AA) and the changes of GST and PON1 enzyme activities in the metabolism. This study involved control group (n = 31) and the study group (n = 52). In the groups, some changes in oxidative stress factors and GST and PON1 enzyme activities which play an important role in metabolism were determined. There are changes in GST activity between study and control groups. The activity of the enzyme were significantly higher in AA groups (p < 0.01) than control. Malondialdehyde (MDA) levels in acute perforated appendicitis (PeA) groups were found significantly higher than control (p <0.01). There is a negative correlation between mean platelet volume (MPV) and lipid peroxidation in AA patients (r=-0.654, p<0.01). An increase in GSH production and GST activity provides an important defense mechanism against the oxidation of some macromolecules and may prevent oxidative stress in patients with appendicitis to some extent.
Oxidative stress, acute appendicitis, cellular defense system, antioxidant enzyme
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Primary Language en
Subjects Engineering
Journal Section Articles
Authors

Orcid: 0000-0003-2178-3369
Author: Ayetullah TEMİZ
Institution: ATATÜRK ÜNİVERSİTESİ, TIP FAKÜLTESİ
Country: Turkey


Orcid: 0000-0002-4677-8104
Author: Mesut IŞIK (Primary Author)
Institution: Harran üniversitesi
Country: Turkey


Orcid: 0000-0002-2535-4329
Author: Yavuz ALBAYRAK
Institution: ATATÜRK ÜNİVERSİTESİ, TIP FAKÜLTESİ
Country: Turkey


Orcid: 0000-0003-2080-0091
Author: Hatice Esra DURAN
Institution: KAFKAS ÜNİVERSİTESİ, TIP FAKÜLTESİ
Country: Turkey


Orcid: 0000-0002-9083-9306
Author: Adem ASLAN
Institution: Erzurum Eğitim ve Araştırma Hastahanesi
Country: Turkey


Orcid: 0000-0003-3216-1098
Author: Yeliz DEMİR
Institution: ARDAHAN ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-5133-0793
Author: Ayse ALBAYRAK
Institution: ATATÜRK ÜNİVERSİTESİ, TIP FAKÜLTESİ
Country: Turkey


Orcid: 0000-0002-5480-1140
Author: Mesut IŞIK
Institution: Erzurum Eğitim ve Araştırma Hastahanesi
Country: Turkey


Orcid: 0000-0003-3667-6902
Author: Şükrü BEYDEMİR
Institution: ANADOLU ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
Country: Turkey


Dates

Publication Date : January 1, 2021

Bibtex @research article { hjbc728686, journal = {Hacettepe Journal of Biology and Chemistry}, issn = {2687-475X}, eissn = {2687-475X}, address = {Hacettepe Üniversitesi Fen Fakültesi, 06532, Beytepe/ ANKARA/ TÜRKİYE}, publisher = {Hacettepe University}, year = {2021}, volume = {49}, pages = {69 - 78}, doi = {10.15671/hjbc.728686}, title = {The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis}, key = {cite}, author = {Temiz, Ayetullah and Işık, Mesut and Albayrak, Yavuz and Duran, Hatice Esra and Aslan, Adem and Demir, Yeliz and Albayrak, Ayse and Işık, Mesut and Beydemir, Şükrü} }
APA Temiz, A , Işık, M , Albayrak, Y , Duran, H , Aslan, A , Demir, Y , Albayrak, A , Işık, M , Beydemir, Ş . (2021). The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis . Hacettepe Journal of Biology and Chemistry , 49 (1) , 69-78 . DOI: 10.15671/hjbc.728686
MLA Temiz, A , Işık, M , Albayrak, Y , Duran, H , Aslan, A , Demir, Y , Albayrak, A , Işık, M , Beydemir, Ş . "The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis" . Hacettepe Journal of Biology and Chemistry 49 (2021 ): 69-78 <https://dergipark.org.tr/en/pub/hjbc/issue/58116/728686>
Chicago Temiz, A , Işık, M , Albayrak, Y , Duran, H , Aslan, A , Demir, Y , Albayrak, A , Işık, M , Beydemir, Ş . "The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis". Hacettepe Journal of Biology and Chemistry 49 (2021 ): 69-78
RIS TY - JOUR T1 - The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis AU - Ayetullah Temiz , Mesut Işık , Yavuz Albayrak , Hatice Esra Duran , Adem Aslan , Yeliz Demir , Ayse Albayrak , Mesut Işık , Şükrü Beydemir Y1 - 2021 PY - 2021 N1 - doi: 10.15671/hjbc.728686 DO - 10.15671/hjbc.728686 T2 - Hacettepe Journal of Biology and Chemistry JF - Journal JO - JOR SP - 69 EP - 78 VL - 49 IS - 1 SN - 2687-475X-2687-475X M3 - doi: 10.15671/hjbc.728686 UR - https://doi.org/10.15671/hjbc.728686 Y2 - 2020 ER -
EndNote %0 Hacettepe Journal of Biology and Chemistry The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis %A Ayetullah Temiz , Mesut Işık , Yavuz Albayrak , Hatice Esra Duran , Adem Aslan , Yeliz Demir , Ayse Albayrak , Mesut Işık , Şükrü Beydemir %T The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis %D 2021 %J Hacettepe Journal of Biology and Chemistry %P 2687-475X-2687-475X %V 49 %N 1 %R doi: 10.15671/hjbc.728686 %U 10.15671/hjbc.728686
ISNAD Temiz, Ayetullah , Işık, Mesut , Albayrak, Yavuz , Duran, Hatice Esra , Aslan, Adem , Demir, Yeliz , Albayrak, Ayse , Işık, Mesut , Beydemir, Şükrü . "The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis". Hacettepe Journal of Biology and Chemistry 49 / 1 (January 2021): 69-78 . https://doi.org/10.15671/hjbc.728686
AMA Temiz A , Işık M , Albayrak Y , Duran H , Aslan A , Demir Y , Albayrak A , Işık M , Beydemir Ş . The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis. HJBC. 2021; 49(1): 69-78.
Vancouver Temiz A , Işık M , Albayrak Y , Duran H , Aslan A , Demir Y , Albayrak A , Işık M , Beydemir Ş . The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis. Hacettepe Journal of Biology and Chemistry. 2021; 49(1): 69-78.
IEEE A. Temiz , M. Işık , Y. Albayrak , H. Duran , A. Aslan , Y. Demir , A. Albayrak , M. Işık and Ş. Beydemir , "The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis", Hacettepe Journal of Biology and Chemistry, vol. 49, no. 1, pp. 69-78, Jan. 2021, doi:10.15671/hjbc.728686