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Autoimmune Diseases and Immunoadsorption Therapy

Year 2011, Volume: 39 Issue: 3, 213 - 229, 01.08.2011

Abstract

The human immune system is structured to recognize, respond to, and destroy a wide variety of potentially harmful microorganisms. One major component of this defense system depends on its ability to recognize foreign antigens versus healthy cells or tissues. When the immune system begins to destroy vital cells and organs within the body, the resulting reaction can be the basis for certain autoimmune diseases. Immunoadsorption, an extracorporeal technique for the removal of autoantibodies from patient plasma, offers some advantages over plasmapheresis. Immunoadsorption appeared relatively rapid and safe for the extensive removal of pathogenic antibodies and immune-complexes. During the mid 1970’s the first application of therapeutic intervention with immunoadsorbents was reported. In this review, some selected applications on immunoadsorption therapies mainly for removal of anti-dsDNA antibodies from systemic lupus erythematosus SLE and rheumatoid factors from rheumatoid arthritis patients plasmas are briefly discussed.

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Otoimmun Hastalıklar ve İmmunoadsorpsiyon Tedavisi

Year 2011, Volume: 39 Issue: 3, 213 - 229, 01.08.2011

Abstract

İ nsan bağışıklık sistemi, zararlı olabilecek bir çok mikroorganizmayı tanıma, karşılık verme ve yok etmeye yönelik düzenlenmiştir. Bu savunma sisteminin temel bileşeni, sağlıklı hücre ve dokulardan yabancı antijenleri ayırt edebilme özelliğine dayanmaktadır. Bağışıklık sisteminin vücut içerisindeki önemli hücre ve dokuları yok etmeye başlamasıyla oluşan reaksiyon bir otoimmun hastalığa sebep olabilmektedir. Hasta plazmasından otoantibadilerin uzaklaştırılması için uygulanan bir ekstrakorporal teknik olan immunoadsorpsiyon, plazmafereze göre önemli avantajlar sunmaktadır. İmmunoadsorpsiyon, patojenik antibadilerin ve immunkomplekslerin uzun süreli uzaklaştırılmasında daha hızlı ve güvenilirdir. İmmunoadsorpsiyonla ilk tedavi amaçlı müdahele 1970’lerin ortalarında uygulanmıştır. Bu derlemede, sistemik lupus eritematos’lu ve romatoid artrit’li plazmalarından antidsDNA antibadilerin ve romatoid faktörlerinin uzaklaştırılması için uygulanılan immunoadsorpsiyon tedavilerine ait seçilen bazı makaleler kısaca tartışılmıştır

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Primary Language English
Journal Section Research Article
Authors

Adil Denizli This is me

Publication Date August 1, 2011
Published in Issue Year 2011 Volume: 39 Issue: 3

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APA Denizli, A. (2011). Autoimmune Diseases and Immunoadsorption Therapy. Hacettepe Journal of Biology and Chemistry, 39(3), 213-229.
AMA Denizli A. Autoimmune Diseases and Immunoadsorption Therapy. HJBC. August 2011;39(3):213-229.
Chicago Denizli, Adil. “Autoimmune Diseases and Immunoadsorption Therapy”. Hacettepe Journal of Biology and Chemistry 39, no. 3 (August 2011): 213-29.
EndNote Denizli A (August 1, 2011) Autoimmune Diseases and Immunoadsorption Therapy. Hacettepe Journal of Biology and Chemistry 39 3 213–229.
IEEE A. Denizli, “Autoimmune Diseases and Immunoadsorption Therapy”, HJBC, vol. 39, no. 3, pp. 213–229, 2011.
ISNAD Denizli, Adil. “Autoimmune Diseases and Immunoadsorption Therapy”. Hacettepe Journal of Biology and Chemistry 39/3 (August 2011), 213-229.
JAMA Denizli A. Autoimmune Diseases and Immunoadsorption Therapy. HJBC. 2011;39:213–229.
MLA Denizli, Adil. “Autoimmune Diseases and Immunoadsorption Therapy”. Hacettepe Journal of Biology and Chemistry, vol. 39, no. 3, 2011, pp. 213-29.
Vancouver Denizli A. Autoimmune Diseases and Immunoadsorption Therapy. HJBC. 2011;39(3):213-29.

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