Bioengineering Functional Copolymers. XX. Synthesis of Novel Anticancer Active Poly maleic anhydride-alt-2-vinyl-1,3-dioxolane and its Organoboron Amide-Ester Branched Derivatives ​

Year 2012, Volume: 40 Issue: 2, 183 - 194, 01.04.2012

Gülten Kahraman Mustafa Türk Zakir M.o. Rzayev Ernur A. Söylemez Serpil Oğuztüzün

Abstract

Novel bioengineering alternating copolymer and its organoboron amide and a-hydroxy-w- methoxypoly ethylene oxide PEO branched derivatives were synthesized by 1 complex-radical alternating copolymerization of two non-homopolymerizable in chosen reaction conditions monomers such as maleic anhydride MA and 2-vinyl-1,3-dioxolane VDO , 2 amidolysis of synthesized poly MA-alt-VDO with 2-aminoethyldiphenylboronate and 3 esterification-grafting of organoboron copolymer with PEO. The complex-formation Kc and the monomer reactivity ratios r1 and r2 copolymerization constants , structure and composition of the synthesized copolymers were characterized by chemical alkali titration , FTIR-ATR and NMR spectroscopy, TGA-DSC thermal analysis methods. Cytotoxicity found as having an order as organoboron branched PEO copolymer < poly MA-alt-VDO < organoboron copolymer of these novel copolymers containing a combination of ionizable, hydrophilic/hydrophobic, organoboron, carboxyl-amide-ester-ether groups, toward HeLa cells was investigated.

Keywords

Synthesis, Alternating copolymer, Amidolysis, Esterification, Organoboron copolymer, Citotoxicity, HeLa cells

Biyomühendislik Fonksiyonel Kopolimerleri. XX. Yeni Antikanser Aktif Poli maleik anhidrid-alt-2- vinil-1,3-dioxolan ve Organoboron Amid-Ester Dallanmış Türevleri

Abstract

Y eni biyomühendislik alternatif kopolimerinin ve organobor amid ve a-hidroksi-w-metoksi-poli etilen oksit PEO ile dallanmış türevlerinin sentezi, 1 Seçilen reaksiyon şartlarında homopolimerleşmeyen maleik anhidriti MA ve 2-vinil-1,3-dioksolan VDO monomerlerinin kompleks-radikal alternatif kopolimerizasyonu, 2 sentezlenenpoli MA-alt-VDO makromoleküllerinin 2-amino-etildifenilboronat ile amidolizi ve 3 PEO ile esterleşmesi yöntemleri kulllanarak gerçekleştirilmiştir. Monomerlerin kompleks oluşumu K ve kopolimerleşme sabitleri r1 ve r2 , çok fonksiyonel gruplar içeren kopolimerlerin yapısı, içeriği ve ısısal özellikleri kimyasal analiz alkali titrasyon , FTIR-ATR and NMR spektroskopisi ve TGA-DSC ile karakterize edilmiştir. İyonize olabilen, hidrofilik/hidrofobik, organobor, anhidrit-karboksil-amid-ester-eter gibi gruplar içeren bu kopolimerlerin HeLa hücrelerine sitotoksik etkisi araştırılmış ve organobor-PEO kopolimer < poli MAalt-VDO < organobor kopolimer sırasında olduğu belirlenmiştir

Keywords

Sentez, Alternatif kopolimer, Amidoliz, Esterleşme, Organobor kopolimer, Sitotoksisite, HeLa hücreleri

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