Adsorption of vitamin B12 in aqueous solutions by poly N-isopropylacrylamide/ itaconic acid copolymeric hydrogels
Year 2014,
Volume: 42 Issue: 1, 35 - 40, 01.03.2014
Betül Taşdelen
Olgun Güven
Bahattin M. Baysal
Abstract
N-isopropylacrylamide/itaconic acid copolymeric hydrogels NIPAAm/IA containing different quantities of itaconic acid have been irradiated with g radiation. The hydrogels were used in an experiment concerning the uptake and release behavior of Vitamin B12. In the experiment of the adsorption of Vitamin B12, type S ad- sorption isotherm was found. The effect of comonomer concentration and irradiation dose on the uptake and release behavior of the hydrogels was studied.
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Poli N-izopropilakrilamid/itakonik asit kopolimerik hidrojelleri tarafından sulu çözeltilerde vitamin B12 adsorpsiyonu
Year 2014,
Volume: 42 Issue: 1, 35 - 40, 01.03.2014
Betül Taşdelen
Olgun Güven
Bahattin M. Baysal
Abstract
Farklı miktarda itakonik asit içereb N-izopropilakrilamid/itakonik asit kopolimerik hidrojelleri NIPAAm/IA g-radyasyonu ile sentezlendi. Sentezlenen hidrojeller Vitamin B12 tutulumu ve salımını incelemekte kullanıldı. Vitamin B12 adsorpsiyon deneylerinde S tipi adsorpsiyon izotermi bulundu. Hidrojellerin ilaç tutulumu ve salımı davranışları üzerinde komonomer konsantrasyonu ve ışınlama dozunun etkileri araştırıldı.
References
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- 2. A. Safrany, Radiaiton processing: synthesis and modification of biomaterials for medical use, Nucl. Instrum. Method B 131 (1997) 376.
- 3. N.A. Peppas P. Bures, W. Leobandung, H. Ichikawa, Hydrogels in pharmaceutical formulations, Eur. J. Pharm. Biopharm. 50 (2000) 27.
- 4. J. Jagur-Grodzinski, Polymeric gels and hydrogels for biomedical and pharmaceutical applications, Polym. Adv. Technol. 21 (2010) 27.
- 5. M. Şen, C. Uzun, O. Güven. Controlled release of terbinafine hydrochloride from pH sensitive poly(acrylamide/maleic acid) hydrogels. Int. J. Pharm. 203 (2000) 149.
- 6. S.L. Tomic, M.M. Micic, S.N. Dobic, J.M. Filipovic, E.H. Suljovrujic, Smart poly(2-hydroxyethyl methacrylate/ itaconic acid) hydrogels for biomedical applications, Rad. Phys. Chem. 79 (2010) 643.
- 7. K.T. Nguyen, J.L. West, Photopolymerizable hydrogels for tissue engineering applications, Biomaterials 23 (2002) 4307.
- 8. Y. Zhuang, H. Yang, G. Wang, Z. Zhu, W. Song, H. Zu, Radiation polymerization and controlled drug release of polymer hydrogels with NIPA and NVP, J. Appl. Polym. Sci. 88 (2003) 724.
- 9. N. Milasinovic, Z. Knezevic-Jugovic, N. Milosavljevic, J. Filipovic, M. K. Krusic, Controlled release of lipase from Candida rugosa loaded into hydrogels of N-isopropylacrylamide and itaconic acid, Int. J. Pharm. 436 (2012) 332.
- 10. A. Safrany and L. Wojnarovits, First steps in radiation-induced hydrogel synthesis: radical formation and oligomerization in dilute aqueous N-isopropylacrylamide solutions, Rad. Phys. Chem. 67 (2003) 707.
- 11. N. Nagaoka, A. Safrani, M. Yoshida, H. Omichi, H. Kuboa, R. Katakai, Synthesis of poly(N-isopropylacrylamide) hydrogels by radiation polymerization and crosslinking, Macromolecules 26 (1993) 386.
- 12. E.Karadag, D.Saraydin, N. Öztop, O.Güven, Adsorption of bovine serum albumin to acrylamide-itaconic acid hydrogels, Polym. Adv. Technol. 5 (1994) 664 .
- 13. D. Saraydin, E. Karadag, S. Cetinkaya, O. Güven, Preparation of acrylamide-maleic acid hydrogels and their use in biocompatibility with some biochemical parameters of human serum, Radiat. Phys. Chem. 46 (1995) 1049.
- 14. M. Şen, A. Yakar, O. Güven, Determination of average molecular weight between cross-links from swelling behaviours of diprotic acid-containing hydrogels. Polymer, 40 (1999) 2969.
- 15. M. Sen, C. Uzun and O. Güven , Controlled release of terbinafine hydrochloride from pH Sensitive poly(acrylamide/maleic acid) hydrogels, Int. J. Pharm. 203 (2000) 149 .
- 16. B. Taşdelen, N. Kayaman-Apohan, O. Güven, B.M. Baysal, Preparation of poly(N-isopropylacrylamide/ itaconic acid) copolymeric hydrogels and their drug release behavior, Int. J. Pharm. 278 (2004) 343.
- 17. B. Taşdelen, N. Kayaman-Apohan, O. Güven, B.M. Baysal, Anti-cancer drug release of of poly(Nisopropylacrylamide/itaconic acid) copolymeric hydrogels, Radiat. Phys. Chem., 73 (2005) 340.
- 18. B. Taşdelen, N. Kayaman-Apohan, O. Güven, B.M. Baysal, pH-thermoreversible hydrogels. I. synthesis and characterization of poly(N-isopropylacrylamide/ maleic acid) copolymeric hydrogels, Radiat. Phys. and Chem. 69 (2004) 303.
- 19. B. Dengre, M. Bajpai, S.K. Bajpai, Release of Vitamin B12 from poly(N-vinyl-2-pyrrolidone)-crosslinked polyacrylamide hydrogels: a kinetic study, J. Appl. Polym. Sci. 78 (2000) 1706.
- 20. H. Rüdiger, L. Jaenicke, On the role of s-adenosylmethionine in vitamin B12 dependent methionine biosynthesis, European J. Biochem., 10 (1969) 557-560.
- 21. P. Molyneux, S. Vekavakayanodha, The interaction of aromatic compounds with polyvinypyrolidone in aqueous solution. Part 5. Binding isotherms for phenols and O-substituted phenols. J. Chem. Soc. Faraday Trans. 1 82 (1986) 291
- 22. E. Karadağ, D. Saraydin, Interaction of some cationic dyes with acrylamide/itaconic acid hydrogels, J. Appl. Polym. Sci. 61 (1996) 2372.
- 23. C.H. Giles, T.H. MacEwan, S.N. Nakhwa, D. Smith, Studies in adsorption. XI. A system of classification of solution adsorption isotherms, and its use in diagnosis of adsorption mechanisms and in measurement of specific surface areas of solids, J. Chem. Soc. (1960) 3973.
- 24. C.H. Giles., A.P. D’Silva,, I. Easton, A general treatment and classification of the solute adsorption isotherm. Part II. Experimental interpretation. J. Coll. Interface Sci. 47 (1974) 766.