Böbrek Hastalıkları için Bazı Biyobelirteçler

Year 2014, Volume: 42 Issue: 4, 557 - 562, 01.11.2014

Aykut Arif Topçu

Abstract

S unulan bu Özet: Böbrekler vücudumuz için; özellikle hemostaz ve atardamar basıncının düzenlenmesi, kanın temizlenmesi, su dengesi ve glukoneogenez gibi görevlerden sorumlu olan hayati organlardan birisidir. Böbrek hastalıkları glomerüler filtrasyon oranına göre; akut böbrek hasarları ve kronik böbrek hastalıkları olarak 2 gruba ayrılmaktadır. Glomerüler filtrasyon oranının son evresi 5. evre zararlı olmasının yanında geri dönüşünü olmayan özellikte olup, böbrek nakli ve diyaliz önemli tedavi yöntemleridir. Günümüze biyobelirteçler hastaların teşhisinde, tedavisinde ve hastalığın seyrini takip etmede kullanılırlar. Bu derlemede kronik böbrek hastalıklarını ile akut böbrek hasarlarını teşhiş etmek için bazı biyobelirteçler araştırma makaleleri ile birlikte sunulmuştur

Keywords

Böbrek hastalıkları, biyobelirteçler, BTP, KIM-1, I-18, NGAL, AD, NAG, Albüminüri, L-FABP, sistatin C

Some Biomarkers of Kidney Diseases

Abstract

Kidneys are one of the indispensible organs of our body especially for hemostasis and responsible for regu- lates arterial pressure, blood filter, water balance, gluconeogenesis etc. Renal diseases have been divided acute kidney injury and chronic kidney diseases according to glomerular filtration rate. At last stage of glome- rular filtration rate 5. stage is not only harmful but also irreversible stage, for overcoming this stage kidney transplant and dialysis are important medical cares. Nowadays biomarkers are useful indicator for diagnostic, therapy and monitoring of diseases control. In this review, some biomarkers were represented and supported by research articles for diagnostic chronic kidney disease with acute kidney injury.

Keywords

Kidney diseases, biomarkers, BTP, KIM-1, I-18, NGAL, AD, NAG, Albuminuria, L-FABP, cystatin-C

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