Ni(II) and Cu(II) complexes of pyridine-carboxamide Schiff base: Synthesis, characterization, and antioxidant activities evaluation

Year 2025, Volume: 53 Issue: 2, 29 - 38, 01.04.2025

Nevin Turan , Olcay Aydın , Kenan Buldurun

https://doi.org/10.15671/hjbc.1597332

Abstract

This research introduces two novel Schiff base complexes: [LNi(H2O)2]H2O and [LCu]3H2O, where L represents (E)-2-(5-bromo-2-hidroksibenzilidenamino)-6-metil-4,5,6,7-tetrahidrotiyeno[2,3-c]piridin-3-karboksamid. These complexes were synthesized by reacting of Schiff base ligand (L) containing ON donor atoms with an equimolar amount of NiCl2∙6H2O and Cu(NO3)2∙3H2O salts. The compounds were extensively characterized using various analytical and spectroscopic techniques, including elemental analysis, FT-IR, 1H-NMR, 13C-NMR, UV-Vis spectroscopy, mass spectrometry, magnetic susceptibility measurements, molar conductivity, and thermogravimetric analysis. Additionally, the antioxidant properties of both the ligand and complexes were evaluated in vitro using three methods: DPPH free radical scavenging activity, ABTS+ cation radical scavenging activity, and CUPRAC reducing power. From the analytical data, it was observed that the Ni(II) complex has an octahedral structure and the Cu(II) complex has a square planar structure. The antioxidant activity results indicated that some of the complex compounds demonstrated superior antioxidant effects compared to the Schiff base ligand.

Keywords

Schiff base, metal complexes, spectroscopic method, DPPH, ABTS, CUPRAC

Ethical Statement

This study does not involve human participants. This study does not involve animal subjects.

Supporting Institution

Muş Alparslan University

Project Number

BAP-22-FEF-4902-08

Thanks

This work was financially supported by the unit of Scientific Research Projects, Muş Alparslan University, Muş/Turkey (Project no: BAP-22-FEF-4902-08)

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