Long-Term Investigation of Total Oxidant and Antioxidant Levels in COVID-19 Patients

Abstract

COVID-19 Hastalarında Total Oksidan ve Antioksidan Düzeylerinin Uzun Vadeli Araştırılması

Öz

Amaç: Koronavirüs hastalığı 2019 (COVID-19), tehlikeli küresel bir pandemi olarak tüm dünyada yüksek morbidite ve mortaliteye yol açmıştır. Oksidatif stres, proteinler, lipitler ve DNA üzerinde güçlü etkilere sahip olup, çeşitli hücresel fonksiyonların bozulmasına neden olmaktadır. Bu nedenle oksidatif stresin; nörodejeneratif, kardiyovasküler hastalıklar, diyabet ve metabolik sendrom gibi birçok hastalığın patogenezinde rol oynadığı gösterilmiştir. COVID-19'da oksidatif stresin olası rolüne dair birçok kanıt bulunmasına rağmen hastalık seyri boyunca nasıl değiştiği bilinmemektedir. Materyal Metod: Bu çalışmaya hafif, orta ve yüksek semptom gösteren 18 kadın, 25 erkek olmak üzere toplam 43 COVID-19 hastaları dahil edilmiştir. Hastalardan; 15. gün, 30. gün, 45. gün ve 60. gün olmak üzere 4 defa venöz kan örnekleri alınıp; serumlarında MDA, Protein karbonil, total antioksidan ve total oksidan düzeyleri ölçülmüştür. Bulgular: Erkeklerde 45. ve 60. günlerdeki total antioksidan düzeyleri kadınlara kıyasla istatistiksel olarak anlamlı ölçüde yüksek bulunmuştur (p<0.05). Total oksidan düzeyleri yüksek semptom gösteren hastalarda diğer semtomlara kıyasla istatistiksel olarak anlamlı ölçüde yüksek bulunmuştur (p<0.05). Hastalar yaşlara göre kıyaslandığında ise MDA, PC ve total oksidan düzeyleri 47 yaşının üzerinde olan hastalarda anlamlı ölçüde yüksek bulunmuştur (p<0.05). Sonuç: COVID-19’un oksidatif strese neden olduğu ve bu durumun membran yapısını bozma, inflamasyon, apoptoz ve semptomların daha şiddetli olmasına neden olacağı kanaatindeyiz. Bu nedenle COVID-19 hastalarına özellikle 47 yaşının üzerindeki erkek hastalarına etkili tedavi stratejilerinden biri olarak antioksidan maddelerin uygulanması önerilebilir.

Anahtar Kelimeler

• COVID-19
• Oksidatif stress
• Total antioksidan
• Total oksidan.

References

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