Research Article
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The Impact of Low Birth Weight and Gestational Age on Premature Retinopathy Outcomes

Year 2025, Volume: 22 Issue: 1, 26 - 31, 26.03.2025
https://doi.org/10.35440/hutfd.1585350
https://izlik.org/JA67AC68WF

Abstract

Background: The study aimed to investigate the incidence and treatment of retinopathy of prematu-rity (ROP) in premature infants, focusing on its relationship with gestational age and birth weight.
Materials and Methods: This retrospective study analyzed 1101 infants with a gestational age of 34 weeks or less and/or a birth weight of 1700 grams or less, screened for ROP between 2021 and 2023.
Results: Fifty-five infants required ROP treatment. ROP incidence was higher in lower birth weight and earlier gestational age groups. Among infants weighing 1000 grams or less, 56.1% developed ROP, compared to 43% in the 1001-1250 gram category and 28.1% in the 1251-1700 gram category. For gestational age, 53.2% of infants less than 27 weeks, 26.8% of 27-34 weeks, and 12.7% of over 34 weeks developed ROP.
Conclusions: Premature infants, especially those with very low birth weight and early gestational age, are at high risk for ROP, necessitating comprehensive screening and timely intervention.

References

  • 1. Zhang L et al. Retinopathy of Prematurity—Targeting Hypoxic and Redox SignalingPathways. Antioxidants (Basel). 2024;13(2):148. doi: 10.3390/antiox13020148.
  • 2. Dogra MR, Katoch D, Dogra M. An update on retinopathy of prematurity (ROP). Indian J Pediatr. 2017;84(12):930-6.
  • 3. Terry TL. Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens: I, pre-liminary report. Am J Ophthalmol. 2018;25:203-4.
  • 4. Prasad M, Ingolfsland EC,Christiansen SP.Modifiable risk factors and Preventative Strategies for Severe Retinopathy of Prematu-rity.Life(Basel).2023;13(5):1075.doi:10.3390/life13051075
  • 5. Vinekar A, Dogra M, Azad RV, Gilbert C, Gopal L, Trese M. The changing scenario of retinopathy of prematurity in middle and low income countries: Unique solutions for unique problems. Indian J Ophthalmol. 2019;67(6):717-9.
  • 6. Bas AY, Koc E, Dilmen U; ROP Neonatal Study Group. Incidence and severity of retinopathy of prematurity in Turkey. Br J Opht-halmol. 2015;99(10):1311-14.
  • 7. Dammann O,Stansfield BK. Neonatal Sepsis as a Cause of Reti-nopathy of Prematurity: An Etiological Explanation. Prog Retin Eye Res. 2023;98:101230. doi: 10.1016/j.preteyeres.2023.101230.
  • 8. Koç E, Baş AY, Özdek Ş, Ovalı F, Başmak H; TOD ROP Komisyonu, TRÇ Grubu. Türkiye Prematüre Retinopatisi Rehberi. Türk Neo-natoloji Derneği. 2016;4-5.
  • 9. Chen J, Smith LE. Retinopathy of prematurity. Angiogenesis. 2007; 10: 133-40.
  • 10. Kim SJ et al. Retinopathy of Prematurity: A Review of Risk Factors and their Clinical Significance. Surv Ophthalmol. 2018 Apr 19;63(5):618–637 doi: 10.1016/j.survophthal.2018.04.002.
  • 11. Hellström A, Carlsson B, Niklasson A, Segnestam K, Boguszewski M, de Lacerda L, et al. IGF-I is critical for normal vascularization of the human retina. J Clin Endocrinol Metab. 2002;87(7):3413-6.
  • 12. Berrocal A et al. Retinopathy of Prematurity: Advances in the Screening and Treatment of Retinopathy of Prematurity Using a Single Center Approach. Am J Ophthalmol. 2021;233:189–215. doi: 10.1016/j.ajo.2021.07.016.
  • 13. Hardy R, Good W, Dobson V, Palmer E, Tung B, Phelps D; Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prema-turity: Results of the early treatment for retinopathy of prema-turity randomized trial. Arch Ophthalmol. 2003;121:1684-94.
  • 14. Shah PK, Narendran V, Kalpana N, Gilbert C. Severe retinopathy of prematurity in big babies in India: history repeating itself?. Indian J Pediatr. 2009;76:801-4.
  • 15. Chen Y, Li X. Characteristics of severe retinopathy of prematu-rity patients in China: a repeat of the first epidemic? Br J Opht-halmol. 2006;90(3):268-71.
  • 16. Yurdakök M. Prematüre retinopatisi. Cocuk Sagligi ve Hastalikla-ri Dergisi. 2019;62.
  • 17. Fierson WM. Section on Ophthalmology, American Academy of Pediatrics, American Academy of Ophthalmology, American As-sociation for Pediatric Ophthalmology and Strabismus. Scree-ning examination of premature infants for retinopathy of pre-maturity. Pediatrics. 2006;117(2):572-6.
  • 18. Holmström G, Hellström A, Jakobsson P, Lundgren P, Tornqvist K, Wallin A. Evaluation of new guidelines for ROP screening in Sweden using SWEDROP–a national quality register. Acta Opht-halmol. 2015;93(3):265-8.
  • 19. Gilbert C, Fielder A, Gordillo L, Quinn G, Semiglia R, Visintin P, et al; International NO-ROP Group. Characteristics of infants with severe retinopathy of prematurity in countries with low, moderate, and high levels of development: implications for screening programs. Pediatrics. 2005;115(5):518-25.
  • 20. Koç E, Baş AY, Özdek Ş, Ovalı F, Başmak H. Türk Neonatoloji Derneği ve Türk Oftalmoloji Derneği prematüre retinopatisi uz-laşı rehberi. Turk Pediatri Ars. 2018;53(Suppl 1):s151-60.
  • 21. Mutlu FM, Altinsoy HI, Mumcuoglu T, Kerimoglu H, Kiliç S, Kul M, et al. Screening for retinopathy of prematurity in a tertiary care newborn unit in Turkey: frequency, outcomes, and risk factor analysis. J Pediatr Ophthalmol Strabismus. 2008;45(5):291-8.
  • 22. Sarikabadayi YU, Aydemir O, Ozen ZT, Aydemir C, Tok L, Oguz SS, et al. Screening for retinopathy of prematurity in a large terti-ary neonatal intensive care unit in Turkey: frequency and risk factors. Ophthalmic Epidemiol. 2011;18(6):269-74.
  • 23. Özbek E, Genel F, Atlıhan F, Güngör İ, Malatyalı R, Menteş J ve ark. Yenidoğan yoğun bakım ünitemizde prematüre retinopatisi insidansı, risk faktörleri ve izlem sonuçları. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi. 2011;1(1):7-12.
  • 24. Good WV, Hardy RJ, Dobson V, Palmer EA, Phelps DL, Quintos M, et al. Early Treatment for Retinopathy of Prematurity Coo-perative Group. The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity study. Pediatrics. 2005;116(1):15-23.
  • 25. Sancak S, Topçuoğlu S, Çelik G, Günay M, Karatekin G. Evalua-tion of the incidence and risk factors of retinopathy of prema-turity. Zeynep Kamil Medical Journal. 2019;50(1):63-8.

Düşük Doğum Ağırlığı ve Gebelik Yaşının Prematüre Retinopatisi Üzerindeki Etkisi

Year 2025, Volume: 22 Issue: 1, 26 - 31, 26.03.2025
https://doi.org/10.35440/hutfd.1585350
https://izlik.org/JA67AC68WF

Abstract

Amaç: Çalışmanın amacı, prematüre bebeklerde prematüre retinopatisi (ROP) insidansı ve tedavisini araştırmak, özellikle gestasyonel yaş ve doğum ağırlığı ile ilişkisini incelemektir.
Materyal ve Metod: Bu retrospektif çalışma, 2021 ve 2023 yılları arasında ROP için taranan, gestas-yon yaşı 34 hafta veya daha az ve/veya doğum ağırlığı 1700 gram veya daha az olan 1101 bebeği analiz etmiştir.
Bulgular: Elli beş bebek ROP tedavisi gerektirmiştir. ROP insidansı, daha düşük doğum ağırlığı ve daha erken gestasyonel yaş gruplarında daha yüksekti. 1000 gram veya daha az ağırlığındaki bebeklerin %56,1'i ROP geliştirirken, 1001-1250 gram kategorisinde %43 ve 1251-1700 gram kategorisinde %28,1 ROP geliştirmiştir. Gestasyonel yaşa göre, 27 haftadan küçük bebeklerin %53,2'si, 27-34 hafta arası bebeklerin %26,8'i ve 34 haftadan büyük bebeklerin %12,7'si ROP geliştirmiştir.
Sonuç: Prematüre bebekler, özellikle çok düşük doğum ağırlığı ve erken gestasyonel yaşa sahip olan-lar, ROP için yüksek risk altındadır ve kapsamlı tarama ve zamanında müdahale gereklidir.

References

  • 1. Zhang L et al. Retinopathy of Prematurity—Targeting Hypoxic and Redox SignalingPathways. Antioxidants (Basel). 2024;13(2):148. doi: 10.3390/antiox13020148.
  • 2. Dogra MR, Katoch D, Dogra M. An update on retinopathy of prematurity (ROP). Indian J Pediatr. 2017;84(12):930-6.
  • 3. Terry TL. Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens: I, pre-liminary report. Am J Ophthalmol. 2018;25:203-4.
  • 4. Prasad M, Ingolfsland EC,Christiansen SP.Modifiable risk factors and Preventative Strategies for Severe Retinopathy of Prematu-rity.Life(Basel).2023;13(5):1075.doi:10.3390/life13051075
  • 5. Vinekar A, Dogra M, Azad RV, Gilbert C, Gopal L, Trese M. The changing scenario of retinopathy of prematurity in middle and low income countries: Unique solutions for unique problems. Indian J Ophthalmol. 2019;67(6):717-9.
  • 6. Bas AY, Koc E, Dilmen U; ROP Neonatal Study Group. Incidence and severity of retinopathy of prematurity in Turkey. Br J Opht-halmol. 2015;99(10):1311-14.
  • 7. Dammann O,Stansfield BK. Neonatal Sepsis as a Cause of Reti-nopathy of Prematurity: An Etiological Explanation. Prog Retin Eye Res. 2023;98:101230. doi: 10.1016/j.preteyeres.2023.101230.
  • 8. Koç E, Baş AY, Özdek Ş, Ovalı F, Başmak H; TOD ROP Komisyonu, TRÇ Grubu. Türkiye Prematüre Retinopatisi Rehberi. Türk Neo-natoloji Derneği. 2016;4-5.
  • 9. Chen J, Smith LE. Retinopathy of prematurity. Angiogenesis. 2007; 10: 133-40.
  • 10. Kim SJ et al. Retinopathy of Prematurity: A Review of Risk Factors and their Clinical Significance. Surv Ophthalmol. 2018 Apr 19;63(5):618–637 doi: 10.1016/j.survophthal.2018.04.002.
  • 11. Hellström A, Carlsson B, Niklasson A, Segnestam K, Boguszewski M, de Lacerda L, et al. IGF-I is critical for normal vascularization of the human retina. J Clin Endocrinol Metab. 2002;87(7):3413-6.
  • 12. Berrocal A et al. Retinopathy of Prematurity: Advances in the Screening and Treatment of Retinopathy of Prematurity Using a Single Center Approach. Am J Ophthalmol. 2021;233:189–215. doi: 10.1016/j.ajo.2021.07.016.
  • 13. Hardy R, Good W, Dobson V, Palmer E, Tung B, Phelps D; Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prema-turity: Results of the early treatment for retinopathy of prema-turity randomized trial. Arch Ophthalmol. 2003;121:1684-94.
  • 14. Shah PK, Narendran V, Kalpana N, Gilbert C. Severe retinopathy of prematurity in big babies in India: history repeating itself?. Indian J Pediatr. 2009;76:801-4.
  • 15. Chen Y, Li X. Characteristics of severe retinopathy of prematu-rity patients in China: a repeat of the first epidemic? Br J Opht-halmol. 2006;90(3):268-71.
  • 16. Yurdakök M. Prematüre retinopatisi. Cocuk Sagligi ve Hastalikla-ri Dergisi. 2019;62.
  • 17. Fierson WM. Section on Ophthalmology, American Academy of Pediatrics, American Academy of Ophthalmology, American As-sociation for Pediatric Ophthalmology and Strabismus. Scree-ning examination of premature infants for retinopathy of pre-maturity. Pediatrics. 2006;117(2):572-6.
  • 18. Holmström G, Hellström A, Jakobsson P, Lundgren P, Tornqvist K, Wallin A. Evaluation of new guidelines for ROP screening in Sweden using SWEDROP–a national quality register. Acta Opht-halmol. 2015;93(3):265-8.
  • 19. Gilbert C, Fielder A, Gordillo L, Quinn G, Semiglia R, Visintin P, et al; International NO-ROP Group. Characteristics of infants with severe retinopathy of prematurity in countries with low, moderate, and high levels of development: implications for screening programs. Pediatrics. 2005;115(5):518-25.
  • 20. Koç E, Baş AY, Özdek Ş, Ovalı F, Başmak H. Türk Neonatoloji Derneği ve Türk Oftalmoloji Derneği prematüre retinopatisi uz-laşı rehberi. Turk Pediatri Ars. 2018;53(Suppl 1):s151-60.
  • 21. Mutlu FM, Altinsoy HI, Mumcuoglu T, Kerimoglu H, Kiliç S, Kul M, et al. Screening for retinopathy of prematurity in a tertiary care newborn unit in Turkey: frequency, outcomes, and risk factor analysis. J Pediatr Ophthalmol Strabismus. 2008;45(5):291-8.
  • 22. Sarikabadayi YU, Aydemir O, Ozen ZT, Aydemir C, Tok L, Oguz SS, et al. Screening for retinopathy of prematurity in a large terti-ary neonatal intensive care unit in Turkey: frequency and risk factors. Ophthalmic Epidemiol. 2011;18(6):269-74.
  • 23. Özbek E, Genel F, Atlıhan F, Güngör İ, Malatyalı R, Menteş J ve ark. Yenidoğan yoğun bakım ünitemizde prematüre retinopatisi insidansı, risk faktörleri ve izlem sonuçları. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi. 2011;1(1):7-12.
  • 24. Good WV, Hardy RJ, Dobson V, Palmer EA, Phelps DL, Quintos M, et al. Early Treatment for Retinopathy of Prematurity Coo-perative Group. The incidence and course of retinopathy of prematurity: findings from the early treatment for retinopathy of prematurity study. Pediatrics. 2005;116(1):15-23.
  • 25. Sancak S, Topçuoğlu S, Çelik G, Günay M, Karatekin G. Evalua-tion of the incidence and risk factors of retinopathy of prema-turity. Zeynep Kamil Medical Journal. 2019;50(1):63-8.
There are 25 citations in total.

Details

Primary Language English
Subjects Ophthalmology
Journal Section Research Article
Authors

Çağrı Mutaf 0000-0001-6612-8160

Ali Hakim Reyhan 0000-0001-8402-0954

İrfan Uzun 0000-0001-6900-6337

Funda Yüksekyayla 0009-0005-6991-4120

Ali Şimşek 0000-0002-5077-8721

Submission Date November 14, 2024
Acceptance Date January 24, 2025
Early Pub Date March 10, 2025
Publication Date March 26, 2025
DOI https://doi.org/10.35440/hutfd.1585350
IZ https://izlik.org/JA67AC68WF
Published in Issue Year 2025 Volume: 22 Issue: 1

Cite

Vancouver 1.Mutaf Ç, Reyhan AH, Uzun İ, Yüksekyayla F, Şimşek A. The Impact of Low Birth Weight and Gestational Age on Premature Retinopathy Outcomes. Harran Üniversitesi Tıp Fakültesi Dergisi [Internet]. 2025 Mar. 1;22(1):26-31. Available from: https://izlik.org/JA67AC68WF

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