Faktör V Leiden Mutasyonu Bulunan Genç Myokard Enfarktüsünde Trombüsün Tirofiban İle Trombolizisi

Abstract

19 yaşında erkek hasta şiddetli göğüs ağrısı ile başvurdu. Hastanın EKG’sinde akut anterolateral myokard enfarktüsü bulundu. Hasta primer perkutan girişim için kateterizasyon laboratuvarına alındı. Koroner anjiyografisinde LAD’nin proksimal segmentinde massif trombüs nedeniyle lümen içerisinde dolum defekti tespit edildi. Trombüsün uzunluğu ve koroner yapının uygun olmamasından dolayı perkutan koroner girişim uygulanmadı. Hastada heterozigot faktör V mutasyon vardı. Glikoprotein Iıb/IIIa inhibitörü tirofiban infüzyonu 48 saat uygulandı. 48 saat sonra kontrol koroner anjiyografi yapıldı, intrakoroner trombüsün tamamen kaybolduğu görüldü. Biz Faktör V Leiden mutasyonu bulunan genç myokard enfarktüsünde trombüsün tirofiban ile başarılı bir şekilde eridiğini gösterdik

Keywords

• Faktör V Leiden,Myokard İnfarktüsü,Tirofiban

Effective Thrombolysis with Tirofiban in young Myocardial Infarction case with FV Leiden Mutation

Abstract

A 19 year-old man presented with severe chest discomfort. The patient had electrocardiographic evidence of acute anterior-lateral wall myocardial infarction. The patient was taken to the catheterization laboratory for primary percutaneous coronary intervention. Coronary angiography revealed intraluminal filling defects due to a massive thrombus in the proximal segment of the left anterior descending coronary artery. Due to the inappropriate coronary structure and length of the thrombus, percutaneous coronary intervention was not performed. Heterozygous factor V Leiden mutation of patient was positive. Glycoprotein IIb/IIIa inhibitor tirofiban infusion was administered for 48 hours. Control coronary angiography performed at 48 hours showed complete disappearance of the intracoronary thrombus. We present a case of effective thrombolysis with tirofiban in young myocardial infarction case with factor V Leiden mutation

Keywords

• Factor V Leiden,Myocardial infarction,Tirofiban

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